About   Help   FAQ
Pfn2
Gene Detail
Symbol

Name
ID
Pfn2
profilin 2
MGI:97550
Synonyms
Pfn
Feature Type
protein coding gene
Genetic Map
Chromosome 3
28.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:57841895-57847564 bp, - strand
From VEGA annotation of GRCm38

  5670 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1974  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: profilin
Gene Tree: Pfn2

Human
homologs
Human Homolog PFN2, profilin 2
NCBI Gene ID 5217
neXtProt AC  NX_P35080
Human Synonyms  D3S1319E, PFL
Human Chr (Location)  3q25.1; chr3:149964904-149970954 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for a knock-out allele display increased synaptic excitability of neocortical glutamatergic neurons due to higher vesicle exocytosis, hyperactivation of the striatum, hyperactivity, and increased novelty-seeking behavior.
 
Interactions
Pfn2 interacts with 309 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process actin cytoskeleton organization, negative regulation of actin filament polymerization, ...
Component cytoplasm, cytoskeleton, ...
Function actin binding, actin monomer binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (88)    Tissues (27)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 73
Western blot 13
RT-PCR 2
cDNA source data(85)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(88) cDNA(86) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000026672 (Evidence)
Ensembl Gene ModelENSMUSG00000027805 (Evidence)
Entrez Gene18645 (Evidence)
UniGene271744
DFCITC1574379
DoTSDT.101251275, DT.491306, DT.99871373
NIA Mouse Gene IndexU024074
PDB2V8C, 2V8F
Consensus CDS ProjectCCDS17364.1
International Mouse Knockout Project StatusPfn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026672 VEGA Gene Model | MGI Sequence Detail 5670 C57BL/6J ±  kb
transcript OTTMUST00000065997 VEGA | MGI Sequence Detail 1827 Not Applicable 
polypeptide OTTMUSP00000032976 VEGA | MGI Sequence Detail 140 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005455 Profilin
InterPro IPR005454 Profilin, chordates
InterPro IPR027310 Profilin conserved site
Protein Ontology PR:000012586 profilin-2
References
(Earliest) J:9773 Widada JS, et al., Total coding sequence of profilin cDNA from Mus musculus macrophage. Nucleic Acids Res. 1989 Apr 11;17(7):2855
(Latest) J:205619 Mouneimne G, et al., Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell. 2012 Nov 13;22(5):615-30
All references(39)
Other
accession IDs
MGD-MRK-13248, MGD-MRK-13250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory