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Cfp Gene Detail
Summary
  • Symbol
    Cfp
  • Name
    complement factor properdin
  • Synonyms
    Pfc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97545
    NCBI Gene: 18636
Location & Maps
more
  • Sequence Map
    ChrX:20925454-20931555 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      6102 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 16.44 cM, cytoband A3
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    CFP, complement factor properdin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CFP, complement factor properdin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BFD, PFC, PFD, PROPERDIN
  • Links
    NCBI Gene ID: 5199
    neXtProt AC: NX_P27918

  • Chr Location
    Xp11.4; chrX:47624213-47630305 (-)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with human CFP associations

Human Disease Mouse Models
       Properdin Deficiency, X-Linked; CFPD   OMIM: 312060
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    4
  • Targeted
    7
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations have defects in the alternative complement pathway.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    25
  • Tissues
    3
  • cDNA Data
    46
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017182 VEGA Gene Model | MGI Sequence Detail 6102 C57BL/6J ±  kb
transcript OTTMUST00000041609 VEGA | MGI Sequence Detail 1636 Not Applicable  
polypeptide OTTMUSP00000018689 VEGA | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    18 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005387 properdin
  • InterPro Domains
    IPR000884 Thrombospondin type-1 (TSP1) repeat
Molecular
Reagents
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  • All nucleic 47
    cDNA 46
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13243
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:7192 Farrar JJ, et al., Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2. J Immunol. 1983 Oct;131(4):1838-42
  • Latest
    J:215053 Steiner T, et al., Protective role for properdin in progression of experimental murine atherosclerosis. PLoS One. 2014;9(3):e92404
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory