Cfp MGI Mouse Gene Detail - MGI:97545 - complement factor properdin

Cfp Gene Detail

Symbol

Cfp
Name

complement factor properdin
Synonyms

Pfc

Feature Type

protein coding gene
IDs

MGI:97545
NCBI Gene: 18636
Alliance

gene page

Sequence Map

ChrX:20925454-20931555 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

6102 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 16.44 cM, cytoband A3
Mapping Data

12 experiments

Human Ortholog

CFP, complement factor properdin

Vertebrate Orthologs

9

Human Ortholog

CFP, complement factor properdin
Orthology source: HomoloGene, HGNC
Synonyms

BFD, PFC, PFD, PROPERDIN
Links

HGNC:8864

NCBI Gene ID: 5199

neXtProt AC: NX_P27918

UniProt: P27918
Chr Location

Xp11.23; chrX:47624213-47630305 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1969
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: CFP
Protein SuperFamily

properdin
Gene Tree

Cfp

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Phenotype Summary

9 phenotypes from 4 alleles in 6 genetic backgrounds
1 phenotype from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

4
Targeted

7
Incidental Mutations

APF
Find Mice (IMSR)

7 strains or lines available

Homozygotes for targeted null mutations have defects in the alternative complement pathway.

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All GO Annotations

4
GO References

1

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

25
Tissues

3
cDNA Data

46
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cfp

ZFIN cfp

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Cfp interacts with 27 markers (Mir16-2, Mir23a, Mir23b, ...) View All

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All Sequences

26
RefSeq

2
UniProt

2
CCDS

CCDS30047.1
UniGene

3064

			Length	Strain/Species	Flank
genomic	OTTMUSG00000017182	VEGA Gene Model \| MGI Sequence Detail	6102	C57BL/6J	± kb
transcript	OTTMUST00000041609	VEGA \| MGI Sequence Detail	1636	Not Applicable
polypeptide	OTTMUSP00000018689	VEGA \| MGI Sequence Detail	464	Not Applicable

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SNPs within 2kb

18 from dbSNP Build 142

RFLP

2

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UniProt

2 Sequences
Protein Ontology

PR:000005387 properdin

(term hierarchy)
InterPro Domains

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily

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All nucleic 47

cDNA 46

Primer pair 1

Microarray probesets 3

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MGD-MRK-13243

Summaries

All 48

Developmental Gene Expression 2

Gene Ontology 1

Phenotypes 15
Earliest

J:7192 Farrar JJ, et al., Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2. J Immunol. 1983 Oct;131(4):1838-42
Latest

J:241547 Freeley SJ, et al., Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5. J Pathol. 2016 Sep;240(1):61-71

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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