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Cfp
Gene Detail
Symbol

Name
ID
Cfp
complement factor properdin
MGI:97545
Synonyms
Pfc
Feature Type
protein coding gene
Genetic Map
Chromosome X
16.44 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
ChrX:20925454-20931555 bp, - strand
From VEGA annotation of GRCm38

  6102 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1969  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

HCOP human homology predictions: CFP
Protein SuperFamily: properdin
Gene Tree: Cfp

Human
homologs
CFP, complement factor properdin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5199
neXtProt AC: NX_P27918

Human Synonyms: BFD, PFC, PFD, PROPERDIN

Human Chr (Location): Xp11.4; chrX:47624213-47630305 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CFP

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations have defects in the alternative complement pathway.
 
Interactions
Cfp interacts with 27 markers (Mir16-2, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process complement activation, alternative pathway, immune system process, ...
Component extracellular matrix, extracellular region
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (25)    Tissues (3)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 1
cDNA source data(46)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cfp ; ZFIN cfp    NEW 
Molecular
reagents
All nucleic(47) cDNA(46) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017182 (Evidence)
Ensembl Gene Model ENSMUSG00000001128 (Evidence)
Entrez Gene 18636 (Evidence)
UniGene 3064
DFCI TC1578516
DoTS DT.101362771, DT.532871
NIA Mouse Gene Index U039299
Consensus CDS Project CCDS30047.1
International Mouse Phenotyping Consortium Status Cfp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017182 VEGA Gene Model | MGI Sequence Detail 6102 C57BL/6J ±  kb
transcript OTTMUST00000041609 VEGA | MGI Sequence Detail 1636 Not Applicable 
polypeptide OTTMUSP00000018689 VEGA | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(3) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000005387 properdin
References
(Earliest) J:7192 Farrar JJ, et al., Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2. J Immunol. 1983 Oct;131(4):1838-42
(Latest) J:215053 Steiner T, et al., Protective role for properdin in progression of experimental murine atherosclerosis. PLoS One. 2014;9(3):e92404
All references(50)
Other
accession IDs
MGD-MRK-13243

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory