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Cfp
Gene Detail
Symbol

Name
ID
Cfp
complement factor properdin
MGI:97545
Synonyms
Pfc
Feature Type
protein coding gene
Genetic Map
Chromosome X
16.44 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
ChrX:20925454-20931555 bp, - strand
From VEGA annotation of GRCm38

  6102 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1969  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: properdin
Gene Tree: Cfp

Human
homologs
Human Homolog CFP, complement factor properdin
NCBI Gene ID 5199
neXtProt AC  NX_P27918
Human Synonyms  BFD, PFC, PFD, PROPERDIN
Human Chr (Location)  Xp11.4; chrX:47624213-47630305 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CFP
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations have defects in the alternative complement pathway.
 
Interactions
Cfp interacts with 27 markers (Mir16-2, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process complement activation, alternative pathway, immune system process, ...
Component extracellular matrix, extracellular region
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (25)    Tissues (3)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 1
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) cDNA(46) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017182 (Evidence)
Ensembl Gene ModelENSMUSG00000001128 (Evidence)
Entrez Gene18636 (Evidence)
UniGene3064
DFCITC1578516
DoTSDT.101362771, DT.532871
NIA Mouse Gene IndexU039299
Consensus CDS ProjectCCDS30047.1
International Mouse Knockout Project StatusCfp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017182 VEGA Gene Model | MGI Sequence Detail 6102 C57BL/6J ±  kb
transcript OTTMUST00000041609 VEGA | MGI Sequence Detail 1636 Not Applicable 
polypeptide OTTMUSP00000018689 VEGA | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(3) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000005387 properdin
References
(Earliest) J:7192 Farrar JJ, et al., Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2. J Immunol. 1983 Oct;131(4):1838-42
(Latest) J:194520 Miwa T, et al., Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice. J Immunol. 2013 Apr 1;190(7):3552-9
All references(49)
Other
accession IDs
MGD-MRK-13243

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory