Cfp
Gene Detail

Symbol Name ID

Cfp complement factor properdin MGI:97545

Synonyms

Pfc

Feature Type

protein coding gene

Genetic Map

Chromosome X

16.44 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

ChrX:20925454-20931555 bp, - strand From VEGA annotation of GRCm38   6102 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1969  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: properdin
Gene Tree: Cfp

Human homologs

Human Homolog		CFP, complement factor properdin
NCBI Gene ID		5199
neXtProt AC		NX_P27918
Human Synonyms		BFD, PFC, PFD, PROPERDIN
Human Chr (Location)		Xp11.4; chrX:47483612-47489704 (-)  GRCh37.p13
Disease Associations		(1) Diseases Associated with Human CFP

Alleles and phenotypes

All alleles(11) : Targeted(7) Gene trapped(4)
 

Homozygotes for targeted null mutations have defects in the alternative complement pathway.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	complement activation, alternative pathway, immune system process, ...
Component	extracellular matrix, extracellular region

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (25)    Tissues (3)    Images (24)
Theiler Stages: 11, 23

Assay Type	Results
RNA in situ	24
RT-PCR	1

cDNA source data(46)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) cDNA(46) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017182 (Evidence)
Ensembl Gene Model	ENSMUSG00000001128 (Evidence)
Entrez Gene	18636 (Evidence)
UniGene	3064
DFCI	TC1578516
DoTS	DT.101362771, DT.532871
NIA Mouse Gene Index	U039299
Consensus CDS Project	CCDS30047.1
International Mouse Knockout Project Status	Cfp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017182	VEGA Gene Model | MGI Sequence Detail	6102	C57BL/6J
transcript	OTTMUST00000041609	VEGA | MGI Sequence Detail	1636	Not Applicable
polypeptide	OTTMUSP00000018689	VEGA | MGI Sequence Detail	464	Not Applicable

All sequences(30) RefSeq(3) UniProt(2)

Polymorphisms

RFLP(2) : SNPs within 2kb(16 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000884	Thrombospondin, type 1 repeat
Protein Ontology	PR:000005387	properdin

References

(Earliest) J:7192 Farrar JJ, et al., Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2. J Immunol. 1983 Oct;131(4):1838-42
(Latest) J:194520 Miwa T, et al., Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice. J Immunol. 2013 Apr 1;190(7):3552-9
All references(49)

Other accession IDs

MGD-MRK-13243