Pdgfa
Gene Detail

Symbol Name ID

Pdgfa platelet derived growth factor, alpha MGI:97527

Feature Type

protein coding gene

Genetic Map

Chromosome 5

77.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr5:138976014-138997370 bp, - strand From VEGA annotation of GRCm38   21357 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32055  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: platelet-derived growth factor
Gene Tree: Pdgfa

Human homologs

Human Homolog		PDGFA, platelet-derived growth factor alpha polypeptide
NCBI Gene ID		5154
neXtProt AC		NX_P04085
Human Synonyms		PDGF1, PDGF-A
Human Chr (Location)		7p22; chr7:536895-559481 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(34) : Targeted(2) Gene trapped(32)
 

Homozygotes for a targeted null mutation die either before E10.0 or postnatally. The latter exhibit lung emphysema, reduced numbers of oligodendrocytes, tremors, and abnormalities of the skin, hair follicles, and gastrointestinal lining.

 

Gene Ontology (GO) classifications

All GO classifications: (58 annotations)

Process	actin cytoskeleton organization, angiogenesis, ...
Component	cell surface, extracellular region, ...
Function	cell surface binding, collagen binding, ...

External Resources: FuncBase

Expression

Literature Summary: (67 records)
Data Summary: Results (700)    Tissues (251)    Images (84)
Theiler Stages: 2, 5, 9, 10, 11, 12, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	21
RNA in situ	541
Northern blot	5
Western blot	13
RT-PCR	94
RNase protection	26

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(4) cDNA(15) Primer pair(3) Other(5)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000025151 (Evidence)
Ensembl Gene Model	ENSMUSG00000025856 (Evidence)
Entrez Gene	18590 (Evidence)
DFCI	TC1581231, TC1590679, TC1619462
DoTS	DT.110672012, DT.492529, DT.97394706
NIA Mouse Gene Index	U026873
Consensus CDS Project	CCDS19802.1
International Mouse Knockout Project Status	Pdgfa

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025151	VEGA Gene Model | MGI Sequence Detail	21357	C57BL/6J
transcript	OTTMUST00000061887	VEGA | MGI Sequence Detail	1543	Not Applicable
polypeptide	OTTMUSP00000030453	VEGA | MGI Sequence Detail	211	Not Applicable

All sequences(58) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(2) : SNPs(70 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023581	Platelet-derived growth factor, conserved site
InterPro	IPR006782	Platelet-derived growth factor, N-terminal
InterPro	IPR000072	Platelet-derived growth factor (PDGF)
Protein Ontology	PR:000012490	platelet-derived growth factor subunit A

References

(Earliest) J:20706 Cochran BH, et al., Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor [published erratum appears in Science 1986 Apr 18;232(4748):307]. Science. 1984 Nov 30;226(4678):1080-2
(Latest) J:194289 Bell SM, et al., Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013 Mar 15;375(2):128-39
All references(145)

Other accession IDs

MGD-MRK-13211