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Pdgfa
Gene Detail
 Symbol
Name
ID
Pdgfa
platelet derived growth factor, alpha
MGI:97527
Feature Type protein coding gene
Genetic Map
Chromosome 5
77.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr5:138976014-138997370 bp, - strand
From VEGA annotation of GRCm38

  21357 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32055  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: platelet-derived growth factor
Gene Tree: Pdgfa

Human
homologs
Human Homolog PDGFA, platelet-derived growth factor alpha polypeptide
NCBI Gene ID 5154
neXtProt AC  NX_P04085
Human Synonyms  PDGF1, PDGF-A
Human Chr (Location)  7p22; chr7:497258-520123 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(32) Targeted(3)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation die either before E10.0 or postnatally. The latter exhibit lung emphysema, reduced numbers of oligodendrocytes, tremors, and abnormalities of the skin, hair follicles, and gastrointestinal lining.
 
Interactions
Pdgfa interacts with 178 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process actin cytoskeleton organization, angiogenesis, ...
Component cell surface, extracellular region, ...
Function collagen binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (73 records)
Data Summary: Results (707)    Tissues (256)    Images (88)
Theiler Stages: 2, 4, 9, 10, 11, 12, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 23
RNA in situ 546
Northern blot 5
Western blot 13
RT-PCR 94
RNase protection 26
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(15) Primer pair(3) Other(5)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025151 (Evidence)
Ensembl Gene ModelENSMUSG00000025856 (Evidence)
Entrez Gene18590 (Evidence)
DFCITC1581231, TC1590679, TC1619462
DoTSDT.110672012, DT.492529, DT.97394706
NIA Mouse Gene IndexU026873
Consensus CDS ProjectCCDS19802.1
International Mouse Knockout Project StatusPdgfa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025151 VEGA Gene Model | MGI Sequence Detail 21357 C57BL/6J ±  kb
transcript OTTMUST00000061887 VEGA | MGI Sequence Detail 1543 Not Applicable 
polypeptide OTTMUSP00000030453 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(6) UniProt(7)
Polymorphisms RFLP(2) : SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023581 Platelet-derived growth factor, conserved site
InterPro IPR006782 Platelet-derived growth factor, N-terminal
InterPro IPR000072 Platelet-derived growth factor (PDGF)
Protein Ontology PR:000012490 platelet-derived growth factor subunit A
References (Earliest) J:20706 Cochran BH, et al., Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor [published erratum appears in Science 1986 Apr 18;232(4748):307]. Science. 1984 Nov 30;226(4678):1080-2
(Latest) J:205009 Andrae J, et al., Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A. Mol Cell Biol. 2013 Oct;33(20):4030-40
All references(151)
Other
accession IDs
MGD-MRK-13211

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory