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Pde6g
Gene Detail
 Symbol
Name
ID
Pde6g
phosphodiesterase 6G, cGMP-specific, rod, gamma
MGI:97526
Synonyms Pdeg
Feature Type protein coding gene
Genetic Map
Chromosome 11
84.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:120447605-120453500 bp, - strand
From VEGA annotation of GRCm38

  5896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1955  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-GMP phosphodiesterase, gamma subunit
Gene Tree: Pde6g

Human
homologs
Human Homolog PDE6G, phosphodiesterase 6G, cGMP-specific, rod, gamma
NCBI Gene ID 5148
neXtProt AC  NX_P18545
Human Synonyms  PDEG, RP57
Human Chr (Location)  17q25; chr17:81650459-81657059 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human PDE6G
Alleles
and
phenotypes
All alleles(7) : Targeted(3) Gene trapped(4)
 
Mice homozygous for disruptions in this gene have poorly developed photoreceptors that degenerate with age.
 
Human Diseases Modeled Using Mouse Pde6g (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process activation of MAPK activity, positive regulation of epidermal growth factor receptor signaling pathway, ...
Function 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (127)    Tissues (107)    Images (22)
Theiler Stages: 15, 17, 19, 20, 21, 22, 24, 26, 28
Assay TypeResults
RNA in situ 108
RT-PCR 19
cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(40) cDNA(38) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000004174 (Evidence)
Ensembl Gene ModelENSMUSG00000025386 (Evidence)
Entrez Gene18588 (Evidence)
UniGene39200
DFCITC1583174, TC1592211
DoTSDT.101300732, DT.60104063, DT.91418779
NIA Mouse Gene IndexU033715
EC3.1.4.35
Consensus CDS ProjectCCDS36389.1
International Mouse Knockout Project StatusPde6g
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004174 VEGA Gene Model | MGI Sequence Detail 5896 C57BL/6J ±  kb
transcript OTTMUST00000009475 VEGA | MGI Sequence Detail 900 Not Applicable 
polypeptide OTTMUSP00000004609 VEGA | MGI Sequence Detail 87 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006952 Retinal cGMP phosphodiesterase, gamma subunit
Protein Ontology PR:000012482 retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
References (Earliest) J:32329 Tuteja N, et al., Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence. FEBS Lett. 1988 May 9;232(1):182-6
(Latest) J:199579 Papal S, et al., The giant spectrin betaV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum Mol Genet. 2013 Sep 15;22(18):3773-88
All references(56)
Other
accession IDs
MGD-MRK-13210

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory