Pde6g
Gene Detail

Symbol Name ID

Pde6g phosphodiesterase 6G, cGMP-specific, rod, gamma MGI:97526

Synonyms

Pdeg

Feature Type

protein coding gene

Genetic Map

Chromosome 11

84.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:120447605-120453500 bp, - strand From VEGA annotation of GRCm38   5896 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1955  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-GMP phosphodiesterase, gamma subunit
Gene Tree: Pde6g

Human homologs

Human Homolog		PDE6G, phosphodiesterase 6G, cGMP-specific, rod, gamma
NCBI Gene ID		5148
neXtProt AC		NX_P18545
Human Synonyms		PDEG, RP57
Human Chr (Location)		17q25; chr17:79617489-79623607 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PDE6G

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)
 

Mice homozygous for disruptions in this gene have poorly developed photoreceptors that degenerate with age.

 
Human Diseases Modeled Using Mouse Pde6g (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	activation of MAPK activity, positive regulation of epidermal growth factor receptor signaling pathway, ...
Function	3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (127)    Tissues (107)    Images (22)
Theiler Stages: 15, 17, 19, 20, 21, 22, 24, 26, 28

Assay Type	Results
RNA in situ	108
RT-PCR	19

cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) cDNA(38) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000004174 (Evidence)
Ensembl Gene Model	ENSMUSG00000025386 (Evidence)
Entrez Gene	18588 (Evidence)
UniGene	39200
DFCI	TC1583174, TC1592211
DoTS	DT.101300732, DT.60104063, DT.91418779
NIA Mouse Gene Index	U033715
EC	3.1.4.35
Consensus CDS Project	CCDS36389.1
International Mouse Knockout Project Status	Pde6g

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004174	VEGA Gene Model | MGI Sequence Detail	5896	C57BL/6J
transcript	OTTMUST00000009475	VEGA | MGI Sequence Detail	900	Not Applicable
polypeptide	OTTMUSP00000004609	VEGA | MGI Sequence Detail	87	Not Applicable

All sequences(30) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(37 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006952	Retinal cGMP phosphodiesterase, gamma subunit
Protein Ontology	PR:000012482	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

References

(Earliest) J:32329 Tuteja N, et al., Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence. FEBS Lett. 1988 May 9;232(1):182-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(55)

Other accession IDs

MGD-MRK-13210