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Pde1b
Gene Detail
 Symbol
Name
ID
Pde1b
phosphodiesterase 1B, Ca2+-calmodulin dependent
MGI:97523
Feature Type protein coding gene
Genetic Map
Chromosome 15
58.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:103503298-103530052 bp, + strand
From NCBI annotation of GRCm38

  26755 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37370  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 1B, calmodulin-dependent
Gene Tree: Pde1b

Human
homologs
Human Homolog PDE1B, phosphodiesterase 1B, calmodulin-dependent
NCBI Gene ID 5153
neXtProt AC  NX_Q01064
Human Synonyms  PDE1B1, PDES1B
Human Chr (Location)  12q13; chr12:54549393-54579239 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(12) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display increased exploratory behavior. Learning deficits and hyperactivity are also observed in some situations.
 
Interactions
Pde1b interacts with 204 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cAMP catabolic process, cellular response to granulocyte macrophage colony-stimulating factor stimulus, ...
Component cytoplasm, neuronal cell body
Function 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (430)    Tissues (225)    Images (66)
Theiler Stages: 22, 23, 26, 28
Assay TypeResults
RNA in situ 326
In situ reporter (knock in) 64
RT-PCR 40
cDNA source data(38)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) Genomic(4) cDNA(38) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022489 (Evidence)
Entrez Gene18574 (Evidence)
UniGene390792
DFCITC1580077, TC1590871, TC1608570
DoTSDT.110789413, DT.530284, DT.97366018
NIA Mouse Gene IndexU016741
EC3.1.4.17
Consensus CDS ProjectCCDS27904.1
International Mouse Knockout Project StatusPde1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18574 NCBI Gene Model | MGI Sequence Detail 26755 C57BL/6J ±  kb
transcript NM_008800 RefSeq | MGI Sequence Detail 3262 C57BL/6 
polypeptide Q01065 UniProt | EBI | MGI Sequence Detail 535 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR013706 3'5'-cyclic nucleotide phosphodiesterase N-terminal
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012467 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Graphical View of Protein Domain Structure
References (Earliest) J:2526 Repaske DR, et al., A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. J Biol Chem. 1992 Sep 15;267(26):18683-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)
Other
accession IDs
MGD-MRK-13207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory