Pde1b
Gene Detail

Symbol Name ID

Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent MGI:97523

Feature Type

protein coding gene

Genetic Map

Chromosome 15

58.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:103503298-103530052 bp, + strand From NCBI annotation of GRCm38   26755 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37370  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 1B, calmodulin-dependent
Gene Tree: Pde1b

Human homologs

Human Homolog		PDE1B, phosphodiesterase 1B, calmodulin-dependent
NCBI Gene ID		5153
neXtProt AC		NX_Q01064
Human Synonyms		PDE1B1, PDES1B
Human Chr (Location)		12q13; chr12:54549393-54579239 (+)  GRCh38

Alleles and phenotypes

All alleles(17) : Targeted(5) Gene trapped(12)
 

Mice homozygous for disruptions in this gene display increased exploratory behavior. Learning deficits and hyperactivity are also observed in some situations.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	cAMP catabolic process, cellular response to granulocyte macrophage colony-stimulating factor stimulus, ...
Component	cytoplasm, neuronal cell body
Function	3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (430)    Tissues (225)    Images (66)
Theiler Stages: 22, 23, 26, 28

Assay Type	Results
RNA in situ	326
In situ reporter (knock in)	64
RT-PCR	40

cDNA source data(38)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(45) Genomic(4) cDNA(38) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022489 (Evidence)
Entrez Gene	18574 (Evidence)
UniGene	390792
DFCI	TC1580077, TC1590871, TC1608570
DoTS	DT.110789413, DT.530284, DT.97366018
NIA Mouse Gene Index	U016741
EC	3.1.4.17
Consensus CDS Project	CCDS27904.1
International Mouse Knockout Project Status	Pde1b

Sequences

Length	Strain/Species
genomic	18574	NCBI Gene Model | MGI Sequence Detail	26755	C57BL/6J
transcript	NM_008800	RefSeq | MGI Sequence Detail	3262	C57BL/6
polypeptide	Q01065	UniProt | EBI | MGI Sequence Detail	535	Not Applicable

All sequences(29) RefSeq(8) UniProt(3)

Polymorphisms

SNPs within 2kb(69 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR023088	3'5'-cyclic nucleotide phosphodiesterase
InterPro	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro	IPR013706	3'5'-cyclic nucleotide phosphodiesterase N-terminal
InterPro	IPR003607	HD/PDEase domain
Protein Ontology	PR:000012467	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

Graphical View of Protein Domain Structure

References

(Earliest) J:2526 Repaske DR, et al., A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. J Biol Chem. 1992 Sep 15;267(26):18683-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)

Other accession IDs

MGD-MRK-13207