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Pde1b Gene Detail
Summary
  • Symbol
    Pde1b
  • Name
    phosphodiesterase 1B, Ca2+-calmodulin dependent
  • Feature Type
    protein coding gene
  • IDs
    MGI:97523
    NCBI Gene: 18574
  • Gene Overview
    MyGene.info: PDE1B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:103503034-103530052 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27019 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.99 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PDE1B, phosphodiesterase 1B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PDE1B, phosphodiesterase 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-79p, PDE1B1, PDES1B
  • Links
    NCBI Gene ID: 5153
    neXtProt AC: NX_Q01064
    UniProt: Q01064

  • Chr Location
    12q13.2; chr12:54549393-54579239 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display increased exploratory behavior. Learning deficits and hyperactivity are also observed in some situations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022489 Ensembl Gene Model | MGI Sequence Detail 27019 C57BL/6J ±  kb
    transcript ENSMUST00000023132 Ensembl | MGI Sequence Detail 3218 Not Applicable  
    polypeptide ENSMUSP00000023132 Ensembl | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      68 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000012467 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
    • EC
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR013706 3'5'-cyclic nucleotide phosphodiesterase N-terminal
      IPR003607 HD/PDEase domain
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 4
      cDNA 38
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13207
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:2526 Repaske DR, et al., A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. J Biol Chem. 1992 Sep 15;267(26):18683-8
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory