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Pde1b Gene Detail
Summary
  • Symbol
    Pde1b
  • Name
    phosphodiesterase 1B, Ca2+-calmodulin dependent
  • Feature Type
    protein coding gene
  • IDs
    MGI:97523
    NCBI Gene: 18574
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:103411461-103438479 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 58.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    438 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97523
 protein coding gene Chr15:103411461-103438483 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022444
 protein coding gene Chr15:105773547-105800351 (+)
A/J MGP_AJ_G0022406
 protein coding gene Chr15:101582651-101609393 (+)
AKR/J MGP_AKRJ_G0022381
 protein coding gene Chr15:104669175-104695930 (+)
BALB/cJ MGP_BALBcJ_G0022410
 protein coding gene Chr15:101631412-101658186 (+)
C3H/HeJ MGP_C3HHeJ_G0022177
 protein coding gene Chr15:104773495-104800212 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022859
 protein coding gene Chr15:109682087-109708830 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020382
 protein coding gene Chr15:97344768-97371213 (+)
CAST/EiJ MGP_CASTEiJ_G0021703
 protein coding gene Chr15:105627876-105658116 (+)
CBA/J MGP_CBAJ_G0022146
 protein coding gene Chr15:113522037-113548771 (+)
DBA/2J MGP_DBA2J_G0022277
 protein coding gene Chr15:100861086-100888148 (+)
FVB/NJ MGP_FVBNJ_G0022253
 protein coding gene Chr15:99914090-99940873 (+)
LP/J MGP_LPJ_G0022346
 protein coding gene Chr15:105920569-105947437 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022275
 protein coding gene Chr15:117009449-117037458 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022871
 protein coding gene Chr15:104701422-104728161 (+)
PWK/PhJ MGP_PWKPhJ_G0021443
 protein coding gene Chr15:101047636-101074956 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021275
 protein coding gene Chr15:104543780-104570776 (+)
WSB/EiJ MGP_WSBEiJ_G0021753
 protein coding gene Chr15:105325444-105352225 (+)



Homology
more
  • Human Ortholog
    PDE1B, phosphodiesterase 1B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE1B, phosphodiesterase 1B
  • Synonyms
    HEL-S-79p, PDE1B1, PDES1B
  • Links
    NCBI Gene ID: 5153
    UniProt: Q01064

  • Chr Location
    12q13.2; chr12:54549601-54579239 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display increased exploratory behavior. Learning deficits and hyperactivity are also observed in some situations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1138
  • Tissues
    227
  • cDNA Data
    39
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022489 Ensembl Gene Model | MGI Sequence Detail 27019 C57BL/6J ±  kb
transcript ENSMUST00000023132 Ensembl | MGI Sequence Detail 3218 Not Applicable  
polypeptide ENSMUSP00000023132 Ensembl | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012467 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
    (term hierarchy)
  • EC
    3.1.4.-, 3.1.4.17
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR013706 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    IPR003607 HD/PDEase domain
  • GlyGen
    Q01065 2 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 47
    Genomic 4
    cDNA 39
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13207
References
more
  • Summaries
    All 57
    Developmental Gene Expression 9
    Gene Ontology 15
    Phenotypes 16
  • Earliest
    J:2526 Repaske DR, et al., A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. J Biol Chem. 1992 Sep 15;267(26):18683-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory