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Cdk18 Gene Detail
Summary
  • Symbol
    Cdk18
  • Name
    cyclin-dependent kinase 18
  • Synonyms
    Pctk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97518
    NCBI Gene: 18557
  • Gene Overview
    MyGene.info: CDK18
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:132113547-132139957 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.24 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97518
protein coding gene Chr1:132112237-132139957 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016466
protein coding gene Chr1:135579320-135606115 (-)
A/J MGP_AJ_G0016449
protein coding gene Chr1:130554062-130582810 (-)
AKR/J MGP_AKRJ_G0016414
protein coding gene Chr1:134388768-134418268 (-)
BALB/cJ MGP_BALBcJ_G0016409
protein coding gene Chr1:130876833-130903636 (-)
C3H/HeJ MGP_C3HHeJ_G0016235
protein coding gene Chr1:134541430-134570123 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016870
protein coding gene Chr1:140615411-140644362 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014581
protein coding gene Chr1:123698008-123725622 (-)
CAST/EiJ MGP_CASTEiJ_G0015815
protein coding gene Chr1:133538639-133566813 (-)
CBA/J MGP_CBAJ_G0016207
protein coding gene Chr1:145399084-145431142 (-)
DBA/2J MGP_DBA2J_G0016314
protein coding gene Chr1:129518678-129545448 (-)
FVB/NJ MGP_FVBNJ_G0016313
protein coding gene Chr1:128144673-128172073 (-)
LP/J MGP_LPJ_G0016385
protein coding gene Chr1:136883311-136912414 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016338
protein coding gene Chr1:151209799-151241400 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016906
protein coding gene Chr1:134149035-134176525 (-)
PWK/PhJ MGP_PWKPhJ_G0015601
protein coding gene Chr1:128499145-128526870 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015388
protein coding gene Chr1:133093691-133120741 (-)
WSB/EiJ MGP_WSBEiJ_G0015877
protein coding gene Chr1:134135162-134163234 (-)



Homology
more
  • Human Ortholog
    CDK18, cyclin dependent kinase 18
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDK18, cyclin dependent kinase 18
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PCTAIRE, PCTAIRE3, PCTK3
  • Links
    NCBI Gene ID: 5129
    neXtProt AC: NX_Q07002
    UniProt: Q07002

  • Chr Location
    1q32.1; chr1:205504556-205532793 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Cdk18
  • Incidental Mutations
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18557 NCBI Gene Model | MGI Sequence Detail 26411 C57BL/6J ±  kb
transcript NM_008795 RefSeq | MGI Sequence Detail 3061 C57BL/6  
polypeptide Q04899 UniProt | EBI | MGI Sequence Detail 451 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    cDNA 29

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13198, MGI:2138128
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory