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Cdk18
Gene Detail
Symbol

Name
ID
Cdk18
cyclin-dependent kinase 18
MGI:97518
Synonyms
Pctk3
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:132112237-132139684 bp, - strand
From VEGA annotation of GRCm38

  27448 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1949  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDK18
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk18

Human
homologs
CDK18, cyclin-dependent kinase 18
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5129
neXtProt AC: NX_Q07002

Human Synonyms: PCTAIRE, PCTAIRE3, PCTK3

Human Chr (Location): 1q31-q32; chr1:205504556-205532793 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cdk18 interacts with 184 markers (Mir15a, Mir23a, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process phosphorylation, protein phosphorylation
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (15)    Tissues (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 15
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cdk18    NEW 
Molecular
reagents
All nucleic(28) cDNA(28)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000049382 (Evidence)
Ensembl Gene Model ENSMUSG00000026437 (Evidence)
Entrez Gene 18557 (Evidence)
UniGene 28130
DFCI TC1582028, TC1739287
DoTS DT.110898934, DT.525941
NIA Mouse Gene Index U021758
EC 2.7.11.22
Consensus CDS Project CCDS15281.1
International Mouse Phenotyping Consortium Status Cdk18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049382 VEGA Gene Model | MGI Sequence Detail 27448 C57BL/6J ±  kb
transcript OTTMUST00000125871 VEGA | MGI Sequence Detail 4355 Not Applicable 
polypeptide OTTMUSP00000068123 VEGA | MGI Sequence Detail 451 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(5) UniProt(4)
Polymorphisms
SNPs within 2kb(222 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012443 cyclin-dependent kinase 18
References
(Earliest) J:3108 Okuda T, et al., PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene. 1992 Nov;7(11):2249-58
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(33)
Other
accession IDs
MGD-MRK-13198, MGI:2138128

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory