Cdk16 MGI Mouse Gene Detail - MGI:97516 - cyclin-dependent kinase 16

Cdk16 Gene Detail

Symbol

Cdk16
Name

cyclin-dependent kinase 16
Synonyms

Crk5, Pctaire1, Pctk1

Feature Type

protein coding gene
IDs

MGI:97516
NCBI Gene: 18555
Gene Overview

MyGene.info: CDK16

Sequence Map

ChrX:20687954-20699880 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

11927 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 16.18 cM
Mapping Data

3 experiments

Human Ortholog

CDK16, cyclin dependent kinase 16

Vertebrate Orthologs

9

Human Ortholog

CDK16, cyclin dependent kinase 16
Orthology source: HomoloGene, HGNC
Synonyms

PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1
Links

HGNC:8749

NCBI Gene ID: 5127

neXtProt AC: NX_Q00536

UniProt: Q00536
Chr Location

Xp11.3; chrX:47217881-47229997 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7878
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CDK16
Protein SuperFamily

kinase-related transforming protein
Gene Tree

Cdk16

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

6
Targeted

5
Find Mice (IMSR)

6 strains or lines available

Mice homozygous for a knock-out allele exhibit male infertility associated with asthenozoospermia and abnormal sperm morphology.

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All GO Annotations

32
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

69
Tissues

24
cDNA Data

20
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdk16

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Cdk16 interacts with 260 markers (Mir7-1, Mir10a, Mir10b, ...) View All

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All Sequences

85
RefSeq

10
UniProt

5
CCDS

CCDS30045.1, CCDS81103.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000017159	VEGA Gene Model \| MGI Sequence Detail	11927	C57BL/6J	± kb
transcript	OTTMUST00000041525	VEGA \| MGI Sequence Detail	3120	Not Applicable
polypeptide	OTTMUSP00000018660	VEGA \| MGI Sequence Detail	496	Not Applicable

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SNPs within 2kb

19 from dbSNP Build 142

PCR

1

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UniProt

5 Sequences
Protein Ontology

PR:000012441 cyclin-dependent kinase 16

(term hierarchy)
EC

2.7.11.22
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 22

cDNA 20

Primer pair 2

Microarray probesets 5

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MGD-MRK-13196, MGD-MRK-2149, MGI:88506

Summaries

All 45

Developmental Gene Expression 7

Gene Ontology 11

Phenotypes 8
Earliest

J:3108 Okuda T, et al., PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene. 1992 Nov;7(11):2249-58
Latest

J:224586 Zi Z, et al., CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse. PLoS Genet. 2015 Aug;11(8):e1005485

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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