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Cdk16
Gene Detail
Symbol

Name
ID
Cdk16
cyclin-dependent kinase 16
MGI:97516
Synonyms
Crk5, Pctaire1, Pctk1
Feature Type
protein coding gene
Genetic Map
Chromosome X
16.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:20687954-20699880 bp, + strand
From VEGA annotation of GRCm38

  11927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7878  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk16

Human
homologs
Human Homolog CDK16, cyclin-dependent kinase 16
NCBI Gene ID 5127
neXtProt AC  NX_Q00536
Human Synonyms  PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1
Human Chr (Location)  Xp11; chrX:47218046-47229997 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Targeted(5)
 
Mice homozygous for a knock-out allele exhibit male infertility associated with asthenozoospermia and abnormal sperm morphology.
 
Interactions
Cdk16 interacts with 260 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell differentiation, exocytosis, ...
Component cell, cell junction, ...
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (69)    Tissues (24)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
Northern blot 30
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(19) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017159 (Evidence)
Ensembl Gene ModelENSMUSG00000031065 (Evidence)
Entrez Gene18555 (Evidence)
DFCITC1572250, TC1593167, TC1628369, TC1703623
DoTSDT.101378632, DT.101378633, DT.101378635, DT.111037413, DT.94129469, DT.94129573, DT.97411822
NIA Mouse Gene IndexU019750
EC2.7.11.22
Consensus CDS ProjectCCDS30045.1
International Mouse Knockout Project StatusCdk16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017159 VEGA Gene Model | MGI Sequence Detail 11927 C57BL/6J ±  kb
transcript OTTMUST00000041525 VEGA | MGI Sequence Detail 3120 Not Applicable 
polypeptide OTTMUSP00000018660 VEGA | MGI Sequence Detail 496 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(8) UniProt(9)
Polymorphisms
PCR(1) : SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012441 cyclin-dependent kinase 16
References
(Earliest) J:3108 Okuda T, et al., PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene. 1992 Nov;7(11):2249-58
(Latest) J:190410 Chen XY, et al., Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells. J Biol Chem. 2012 Aug 31;287(36):30368-75
All references(47)
Other
accession IDs
MGD-MRK-13196, MGD-MRK-2149, MGI:88506

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory