Cdk16
Gene Detail

Symbol

Name
ID

Cdk16
cyclin-dependent kinase 16
MGI:97516

Synonyms

Crk5, Pctaire1, Pctk1

Feature Type

protein coding gene

Genetic Map

Chromosome X
16.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:20687954-20699880 bp, + strand From VEGA annotation of GRCm38   11927 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7878  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk16

Human
homologs

Human Homolog		CDK16, cyclin-dependent kinase 16
NCBI Gene ID		5127
neXtProt AC		NX_Q00536
Human Synonyms		PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1
Human Chr (Location)		Xp11; chrX:47218046-47229997 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(11) : Gene trapped(6) Targeted(5)
 

Mice homozygous for a knock-out allele exhibit male infertility associated with asthenozoospermia and abnormal sperm morphology.

 

Interactions

Cdk16 interacts with 260 markers (Mir7-1, Mir10a, Mir10b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (31 annotations)

Process	cell differentiation, exocytosis, ...
Component	cell, cell junction, ...
Function	ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (69)    Tissues (24)    Images (18)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	39
Northern blot	30

cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(21) cDNA(19) Primer pair(2)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000017159 (Evidence)
Ensembl Gene Model	ENSMUSG00000031065 (Evidence)
Entrez Gene	18555 (Evidence)
DFCI	TC1572250, TC1593167, TC1628369, TC1703623
DoTS	DT.101378632, DT.101378633, DT.101378635, DT.111037413, DT.94129469, DT.94129573, DT.97411822
NIA Mouse Gene Index	U019750
EC	2.7.11.22
Consensus CDS Project	CCDS30045.1
International Mouse Knockout Project Status	Cdk16

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017159	VEGA Gene Model | MGI Sequence Detail	11927	C57BL/6J
transcript	OTTMUST00000041525	VEGA | MGI Sequence Detail	3120	Not Applicable
polypeptide	OTTMUSP00000018660	VEGA | MGI Sequence Detail	496	Not Applicable

All sequences(88) RefSeq(8) UniProt(9)

Polymorphisms

PCR(1) : SNPs within 2kb(19 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000012441	cyclin-dependent kinase 16

References

(Earliest) J:3108 Okuda T, et al., PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene. 1992 Nov;7(11):2249-58
(Latest) J:190410 Chen XY, et al., Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells. J Biol Chem. 2012 Aug 31;287(36):30368-75
All references(47)

Other
accession IDs

MGD-MRK-13196, MGD-MRK-2149, MGI:88506