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Pcp4 Gene Detail
Summary
  • Symbol
    Pcp4
  • Name
    Purkinje cell protein 4
  • Synonyms
    P16Rimb19, Pcp-4, Pep19
  • Feature Type
    protein coding gene
  • IDs
    MGI:97509
    NCBI Gene: 18546
  • Gene Overview
    MyGene.info: PCP4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:96467606-96525789 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 56.97 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    552 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97509
protein coding gene Chr16:96467606-96525793 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023087
protein coding gene Chr16:97852209-97912619 (+)
A/J MGP_AJ_G0023055
protein coding gene Chr16:93221109-93280342 (+)
AKR/J MGP_AKRJ_G0023025
protein coding gene Chr16:96086839-96147937 (+)
BALB/cJ MGP_BALBcJ_G0023057
protein coding gene Chr16:93772668-93831685 (+)
C3H/HeJ MGP_C3HHeJ_G0022818
protein coding gene Chr16:96613959-96674232 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023504
protein coding gene Chr16:100950879-101010443 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021006
protein coding gene Chr16:91062703-91121384 (+)
CAST/EiJ MGP_CASTEiJ_G0022338
protein coding gene Chr16:97413413-97474374 (+)
CBA/J MGP_CBAJ_G0022787
protein coding gene Chr16:105314316-105377434 (+)
DBA/2J MGP_DBA2J_G0022921
protein coding gene Chr16:93096245-93154273 (+)
FVB/NJ MGP_FVBNJ_G0022895
protein coding gene Chr16:92267333-92325733 (+)
LP/J MGP_LPJ_G0022991
protein coding gene Chr16:97492726-97553451 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022916
protein coding gene Chr16:109525153-109586831 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023522
protein coding gene Chr16:96622197-96681282 (+)
PWK/PhJ MGP_PWKPhJ_G0022082
protein coding gene Chr16:93387799-93448700 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021912
protein coding gene Chr16:96162984-96225014 (+)
WSB/EiJ MGP_WSBEiJ_G0022388
protein coding gene Chr16:96889805-96951997 (+)



Homology
more
  • Human Ortholog
    PCP4, Purkinje cell protein 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PCP4, Purkinje cell protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PEP-19
  • Links
    NCBI Gene ID: 5121
    neXtProt AC: NX_P48539
    UniProt: P48539

  • Chr Location
    21q22.2; chr21:39867421-39929397 (+)  GRCh38.p7

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired motor learning and abnormal synaptic plasticity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18546 NCBI Gene Model | MGI Sequence Detail 58184 C57BL/6J ±  kb
    transcript NM_008791 RefSeq | MGI Sequence Detail 658 Not Specified  
    polypeptide P63054 UniProt | EBI | MGI Sequence Detail 62 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR033236 Calmodulin regulator protein PCP4
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 8
      cDNA 19
      Primer pair 5
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13098, MGD-MRK-13184, MGD-MRK-13187
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 29
      Diseases 3
      Gene Ontology 3
      Phenotypes 27
    • Earliest
      J:14637 Oberdick J, et al., A Purkinje cell differentiation marker shows a partial DNA sequence homology to the cellular sis/PDGF2 gene [published erratum appears in Neuron 1989 Sep;3(3):following 385]. Neuron. 1988 Jul;1(5):367-76
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    08/06/2019
    MGI 6.14
    The Jackson Laboratory