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Pcmt1
Gene Detail
Symbol

Name
ID
Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
MGI:97502
Synonyms
PIMT, protein carboxyl methyltransferase
Feature Type
protein coding gene
Genetic Map
Chromosome 10
2.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:7629373-7681136 bp, - strand
From VEGA annotation of GRCm38

  51764 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:135759  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque

Protein SuperFamily: protein-L-isoaspartate(D-aspartate) O-methyltransferase
Gene Tree: Pcmt1

Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Gene trapped(46) Targeted(4)
 
Homozygous disruption of this gene causes accumulation of modified proteins, growth retardation and fatal epileptic seizures. Homozygotes for one null allele also show a small spleen, altered lipid, hormone, mineral and enzyme profiles, kyphosis, enlarged brain and abnormal dendritic arborizations.
 
Interactions
Pcmt1 interacts with 283 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(6) cDNA(19) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000034975 (Evidence)
Ensembl Gene ModelENSMUSG00000019795 (Evidence)
Entrez Gene18537 (Evidence)
DFCITC1575598, TC1583854, TC1588993, TC1599532, TC1652427, TC1698994
EC2.1.1.77
Consensus CDS ProjectCCDS23687.2
International Mouse Knockout Project StatusPcmt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034975 VEGA Gene Model | MGI Sequence Detail 51764 C57BL/6J ±  kb
transcript OTTMUST00000088932 VEGA | MGI Sequence Detail 2757 Not Applicable 
polypeptide OTTMUSP00000048539 VEGA | MGI Sequence Detail 286 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(20) UniProt(11)
Polymorphisms
RFLP(2) : SNPs within 2kb(240 from dbSNP Build 137)    SNPs within 2kb including multiple locations(248)
Protein-related
information
ResourceIDDescription
InterPro IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Protein Ontology PR:000012420 protein-L-isoaspartate(D-aspartate) O-methyltransferase
References
(Earliest) J:2260 Romanik EA, et al., Genomic organization and tissue expression of the murine gene encoding the protein beta-aspartate methyltransferase. Gene. 1992 Sep 10;118(2):217-22
(Latest) J:209318 Qin Z, et al., Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent. PLoS One. 2013;8(11):e80758
All references(53)
Other
accession IDs
MGD-MRK-13176, MGI:2143926

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory