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Pcmt1 Gene Detail
Summary
  • Symbol
    Pcmt1
  • Name
    protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
  • Synonyms
    PIMT, protein carboxyl methyltransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:97502
    NCBI Gene: 18537
Location & Maps
more
  • Sequence Map
    Chr10:7629373-7681136 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51764 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 2.26 cM
  • Mapping Data
    5 experiments
Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    50
  • Gene trapped
    46
  • Targeted
    4
Homozygous disruption of this gene causes accumulation of modified proteins, growth retardation and fatal epileptic seizures. Homozygotes for one null allele also show a small spleen, altered lipid, hormone, mineral and enzyme profiles, kyphosis, enlarged brain and abnormal dendritic arborizations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034975 VEGA Gene Model | MGI Sequence Detail 51764 C57BL/6J ±  kb
transcript OTTMUST00000088932 VEGA | MGI Sequence Detail 2757 Not Applicable  
polypeptide OTTMUSP00000048539 VEGA | MGI Sequence Detail 286 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    214 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000012420 protein-L-isoaspartate(D-aspartate) O-methyltransferase
  • EC
  • InterPro Domains
    IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Molecular
Reagents
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  • All nucleic 26
    Genomic 6
    cDNA 19
    Other 1

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-13176, MGI:2143926
References
more
  • Summaries
    All 54
    Gene Ontology 4
    Phenotypes 25
  • Earliest
    J:2260 Romanik EA, et al., Genomic organization and tissue expression of the murine gene encoding the protein beta-aspartate methyltransferase. Gene. 1992 Sep 10;118(2):217-22
  • Latest
    J:219496 Qin Z, et al., Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging. Neurobiol Aging. 2015 Feb;36(2):1029-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory