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Pcca
Gene Detail
Symbol

Name
ID
Pcca
propionyl-Coenzyme A carboxylase, alpha polypeptide
MGI:97499
Synonyms
C79630
Feature Type
protein coding gene
Genetic Map
Chromosome 14
65.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:122534324-122891100 bp, + strand
From VEGA annotation of GRCm38

  356777 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:236  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: acetyl/propionyl/3-methylcrotonyl-CoA carboxylase, alpha subunit
Gene Tree: Pcca

Human
homologs
Human Homolog PCCA, propionyl CoA carboxylase, alpha polypeptide
NCBI Gene ID 5095
neXtProt AC  NX_P05165
Human Chr (Location)  13q32; chr13:100089015-100530437 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PCCA
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die 24-36 hours after birth due to accelerated ketoacidosis. Death is preceded by reduced milk intake, poor movement, dehydration, accumulation of propionyl-CoA, ketonuria, increased fat deposition and glycogen consumption in liver, and enlarged kidney collecting ducts.
 
Interactions
Pcca interacts with 147 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process metabolic process
Component mitochondrion
Function ATP binding, biotin carboxylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (195)    Tissues (109)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 195
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000025744 (Evidence)
Ensembl Gene ModelENSMUSG00000041650 (Evidence)
Entrez Gene110821 (Evidence)
NIA Mouse Gene IndexU016000
EC6.4.1.3
Consensus CDS ProjectCCDS27350.1
International Mouse Knockout Project StatusPcca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025744 VEGA Gene Model | MGI Sequence Detail 356777 C57BL/6J ±  kb
transcript OTTMUST00000063407 VEGA | MGI Sequence Detail 2592 Not Applicable 
polypeptide OTTMUSP00000031341 VEGA | MGI Sequence Detail 724 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(11) UniProt(15)
Polymorphisms
SNPs within 2kb(447 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011761 ATP-grasp fold
InterPro IPR013815 ATP-grasp fold, subdomain 1
InterPro IPR013816 ATP-grasp fold, subdomain 2
InterPro IPR001882 Biotin-binding site
InterPro IPR005482 Biotin carboxylase, C-terminal
InterPro IPR011764 Biotin carboxylation domain
InterPro IPR000089 Biotin/lipoyl attachment
InterPro IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
InterPro IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
InterPro IPR016185 Pre-ATP-grasp domain
InterPro IPR011054 Rudiment single hybrid motif
InterPro IPR003189 Shiga-like toxin, beta subunit
InterPro IPR011053 Single hybrid motif
Protein Ontology PR:000012339 propionyl-CoA carboxylase alpha chain, mitochondrial
References
(Earliest) J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGD-MRK-13172, MGI:2145863

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory