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Pam
Gene Detail
 Symbol
Name
ID
Pam
peptidylglycine alpha-amidating monooxygenase
MGI:97475
Synonyms PHM
Feature Type protein coding gene
Genetic Map
Chromosome 1
47.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr1:97795114-98095646 bp, - strand
From VEGA annotation of GRCm38

  300533 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37369  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: peptidylglycine monooxygenase II
Gene Tree: Pam

Human
homologs
Human Homolog PAM, peptidylglycine alpha-amidating monooxygenase
NCBI Gene ID 5066
neXtProt AC  NX_P19021
Human Synonyms  PAL, PHM
Human Chr (Location)  5q14-q21; chr5:102755276-103031105 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality during fetal growth and development, edema, abnormal yolk sac vasculature, thin arterial walls, and abnormal bronchial epithelial morphology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process long-chain fatty acid metabolic process, metabolic process, ...
Component cell surface, cytoplasmic vesicle, ...
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (277)    Tissues (52)    Images (29)
Theiler Stages: 13, 22, 23
Assay TypeResults
RNA in situ 271
RT-PCR 6
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034777 (Evidence)
Ensembl Gene ModelENSMUSG00000026335 (Evidence)
Entrez Gene18484 (Evidence)
DFCITC1583090, TC1625512
DoTSDT.485537, DT.525300, DT.91296408
NIA Mouse Gene IndexU021642
EC1.14.17.3, 4.3.2.5
Consensus CDS ProjectCCDS48331.1
International Mouse Knockout Project StatusPam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034777 VEGA Gene Model | MGI Sequence Detail 300533 C57BL/6J ±  kb
transcript OTTMUST00000088381 VEGA | MGI Sequence Detail 4095 Not Applicable 
polypeptide OTTMUSP00000048159 VEGA | MGI Sequence Detail 979 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(14) UniProt(9)
Polymorphisms RFLP(3) : SNPs within 2kb(3305 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020611 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
InterPro IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
InterPro IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
InterPro IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
InterPro IPR001258 NHL repeat
InterPro IPR013017 NHL repeat, subgroup
InterPro IPR000720 Peptidyl-glycine alpha-amidating monooxygenase
InterPro IPR008977 PHM/PNGase F domain
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000012252 peptidyl-glycine alpha-amidating monooxygenase
References (Earliest) J:3062 Ouafik LH, et al., The multifunctional peptidylglycine alpha-amidating monooxygenase gene: exon/intron organization of catalytic, processing, and routing domains. Mol Endocrinol. 1992 Oct;6(10):1571-84
(Latest) J:203911 Gaier ED, et al., Peptidylglycine alpha-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. J Neurochem. 2013 Aug 28;
All references(44)
Other
accession IDs
MGD-MRK-13129

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory