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Pam
Gene Detail
Symbol

Name
ID
Pam
peptidylglycine alpha-amidating monooxygenase
MGI:97475
Synonyms
PHM
Feature Type
protein coding gene
Genetic Map
Chromosome 1
47.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr1:97795114-98095646 bp, - strand
From VEGA annotation of GRCm38

  300533 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37369  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PAM
Protein SuperFamily: peptidylglycine monooxygenase II
Gene Tree: Pam

Human
homologs
PAM, peptidylglycine alpha-amidating monooxygenase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5066
neXtProt AC: NX_P19021

Human Synonyms: PAL, PHM

Human Chr (Location): 5q14-q21; chr5:102755276-103031105 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in embryonic lethality during fetal growth and development, edema, abnormal yolk sac vasculature, thin arterial walls, and abnormal bronchial epithelial morphology.
 
Interactions
Pam interacts with 216 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process long-chain fatty acid metabolic process, metabolic process, ...
Component cell surface, cytoplasmic vesicle, ...
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (277)    Tissues (52)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 271
RT-PCR 6
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pam    NEW 
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034777 (Evidence)
Ensembl Gene Model ENSMUSG00000026335 (Evidence)
Entrez Gene 18484 (Evidence)
DFCI TC1583090, TC1625512
DoTS DT.485537, DT.525300, DT.91296408
NIA Mouse Gene Index U021642
EC 1.14.17.3, 4.3.2.5
Consensus CDS Project CCDS48331.1
International Mouse Phenotyping Consortium Status Pam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034777 VEGA Gene Model | MGI Sequence Detail 300533 C57BL/6J ±  kb
transcript OTTMUST00000088381 VEGA | MGI Sequence Detail 4095 Not Applicable 
polypeptide OTTMUSP00000048159 VEGA | MGI Sequence Detail 979 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(20) UniProt(9)
Polymorphisms
RFLP(3) : SNPs within 2kb(3305 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024548 Copper type II ascorbate-dependent monooxygenase, C-terminal
InterPro IPR020611 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
InterPro IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
InterPro IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
InterPro IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
InterPro IPR001258 NHL repeat
InterPro IPR013017 NHL repeat, subgroup
InterPro IPR000720 Peptidyl-glycine alpha-amidating monooxygenase
InterPro IPR008977 PHM/PNGase F domain
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000012252 peptidyl-glycine alpha-amidating monooxygenase
References
(Earliest) J:3062 Ouafik LH, et al., The multifunctional peptidylglycine alpha-amidating monooxygenase gene: exon/intron organization of catalytic, processing, and routing domains. Mol Endocrinol. 1992 Oct;6(10):1571-84
(Latest) J:217538 Lui JH, et al., Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex. Nature. 2014 Nov 13;515(7526):264-8
All references(44)
Other
accession IDs
MGD-MRK-13129

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory