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P4ha1
Gene Detail
Symbol

Name
ID
P4ha1
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
MGI:97463
Synonyms
P4ha
Feature Type
protein coding gene
Genetic Map
Chromosome 10
29.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:59323296-59373304 bp, + strand
From VEGA annotation of GRCm38

  50009 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30998  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 2 zebrafish

HCOP human homology predictions: P4HA1
Protein SuperFamily: procollagen-proline,2-oxoglutarate 4-dioxygenase alpha chain
Gene Tree: P4ha1

Human
homologs
P4HA1, prolyl 4-hydroxylase, alpha polypeptide I
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5033
neXtProt AC: NX_P13674

Human Synonyms: P4HA

Human Chr (Location): 10q22.1; chr10:73007217-73096974 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(18) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display embryonic lethality during organogenesis, capillary ruptures, and impaired basement membrane formation.
 
Interactions
P4ha1 interacts with 261 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process collagen fibril organization, oxidation-reduction process, ...
Component endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function dioxygenase activity, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (232)    Tissues (125)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 232
cDNA source data(80)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100490484    NEW 
Molecular
reagents
All nucleic(81) cDNA(81)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034134 (Evidence)
Ensembl Gene Model ENSMUSG00000019916 (Evidence)
Entrez Gene 18451 (Evidence)
UniGene 2212
DFCI TC1575899, TC1589770, TC1629503, TC1644322
DoTS DT.101158381
NIA Mouse Gene Index U011546
EC 1.14.11.2
Consensus CDS Project CCDS23863.1
International Mouse Phenotyping Consortium Status P4ha1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034134 VEGA Gene Model | MGI Sequence Detail 50009 C57BL/6J ±  kb
transcript OTTMUST00000086404 VEGA | MGI Sequence Detail 2918 Not Applicable 
polypeptide OTTMUSP00000046788 VEGA | MGI Sequence Detail 534 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(11) UniProt(5)
Polymorphisms
SNPs within 2kb(360 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
InterPro IPR006620 Prolyl 4-hydroxylase, alpha subunit
InterPro IPR013547 Prolyl 4-hydroxylase alpha-subunit, N-terminal
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
Protein Ontology PR:000012196 prolyl 4-hydroxylase subunit alpha-1
References
(Earliest) J:10604 Helaakoski T, et al., Increases in mRNA concentrations of the alpha and beta subunits of prolyl 4-hydroxylase accompany increased gene expression of type IV collagen during differentiation of mouse F9 cells. J Biol Chem. 1990 Jul 15;265(20):11413-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGD-MRK-13113, MGI:2143707

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory