About   Help   FAQ
P4ha1
Gene Detail
 Symbol
Name
ID
P4ha1
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
MGI:97463
Synonyms P4ha
Feature Type protein coding gene
Genetic Map
Chromosome 10
29.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:59323296-59373304 bp, + strand
From VEGA annotation of GRCm38

  50009 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30998  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: procollagen-proline,2-oxoglutarate 4-dioxygenase alpha chain
Gene Tree: P4ha1

Human
homologs
Human Homolog P4HA1, prolyl 4-hydroxylase, alpha polypeptide I
NCBI Gene ID 5033
neXtProt AC  NX_P13674
Human Synonyms  P4HA
Human Chr (Location)  10q21.3-q23.1; chr10:73007217-73096974 (-)  GRCh38
Alleles
and
phenotypes
All alleles(21) : Gene trapped(18) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality during organogenesis, capillary ruptures, and impaired basement membrane formation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process collagen fibril organization, oxidation-reduction process, ...
Component endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function dioxygenase activity, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (232)    Tissues (125)    Images (39)
Theiler Stages: 17, 20, 22, 23, 28
Assay TypeResults
RNA in situ 232
cDNA source data(80)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(81) cDNA(81)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034134 (Evidence)
Ensembl Gene ModelENSMUSG00000019916 (Evidence)
Entrez Gene18451 (Evidence)
UniGene2212
DFCITC1575899, TC1589770, TC1629503, TC1644322
DoTSDT.101158381
NIA Mouse Gene IndexU011546
EC1.14.11.2
Consensus CDS ProjectCCDS23863.1
International Mouse Knockout Project StatusP4ha1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034134 VEGA Gene Model | MGI Sequence Detail 50009 C57BL/6J ±  kb
transcript OTTMUST00000086403 VEGA | MGI Sequence Detail 4043 Not Applicable 
polypeptide OTTMUSP00000046787 VEGA | MGI Sequence Detail 534 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(11) UniProt(5)
Polymorphisms SNPs within 2kb(360 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
InterPro IPR006620 Prolyl 4-hydroxylase, alpha subunit
InterPro IPR013547 Prolyl 4-hydroxylase alpha-subunit, N-terminal
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
Protein Ontology PR:000012196 prolyl 4-hydroxylase subunit alpha-1
References (Earliest) J:10604 Helaakoski T, et al., Increases in mRNA concentrations of the alpha and beta subunits of prolyl 4-hydroxylase accompany increased gene expression of type IV collagen during differentiation of mouse F9 cells. J Biol Chem. 1990 Jul 15;265(20):11413-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)
Other
accession IDs
MGD-MRK-13113, MGI:2143707

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory