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Oxt Gene Detail
Summary
  • Symbol
    Oxt
  • Name
    oxytocin
  • Synonyms
    Oxy
  • Feature Type
    protein coding gene
  • IDs
    MGI:97453
    NCBI Gene: 18429
  • Gene Overview
    MyGene.info: OXT
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130576173-130577054 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.24 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97453
protein coding gene Chr2:130574520-130577054 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026508
protein coding gene Chr2:134041221-134042099 (+)
A/J MGP_AJ_G0026472
protein coding gene Chr2:128615585-128616466 (+)
AKR/J MGP_AKRJ_G0026447
protein coding gene Chr2:132325230-132326111 (+)
BALB/cJ MGP_BALBcJ_G0026484
protein coding gene Chr2:128970643-128971518 (+)
C3H/HeJ MGP_C3HHeJ_G0026227
protein coding gene Chr2:132755489-132756403 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026929
protein coding gene Chr2:138182954-138183837 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024306
protein coding gene Chr2:123359618-123360469 (+)
CAST/EiJ MGP_CASTEiJ_G0025688
protein coding gene Chr2:133012220-133013126 (+)
CBA/J MGP_CBAJ_G0026207
protein coding gene Chr2:143288049-143289005 (+)
DBA/2J MGP_DBA2J_G0026341
protein coding gene Chr2:128002389-128003271 (+)
FVB/NJ MGP_FVBNJ_G0026305
protein coding gene Chr2:126629249-126631529 (+)
LP/J MGP_LPJ_G0026446
protein coding gene Chr2:134287324-134288205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026325
protein coding gene Chr2:147139719-147140615 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026984
protein coding gene Chr2:132279524-132280405 (+)
PWK/PhJ MGP_PWKPhJ_G0025424
protein coding gene Chr2:127558019-127558931 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025226
protein coding gene Chr2:131402618-131403503 (+)
WSB/EiJ MGP_WSBEiJ_G0025762
protein coding gene Chr2:133202242-133203181 (+)



Homology
more
  • Human Ortholog
    OXT, oxytocin/neurophysin I prepropeptide
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OXT, oxytocin/neurophysin I prepropeptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OT, OT-NPI, OXT-NPI
  • Links
    NCBI Gene ID: 5020
    neXtProt AC: NX_P01178
    UniProt: P01178

  • Chr Location
    20p13; chr20:3068871-3072517 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 5 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Female homozygotes for targeted null mutations are unable to release milk for their suckling pups, while mutant males fail to develop social memory and are less aggressive. Both genders exhibit increased salt intake.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027301 Ensembl Gene Model | MGI Sequence Detail 882 C57BL/6J ±  kb
    transcript ENSMUST00000028764 Ensembl | MGI Sequence Detail 537 Not Applicable  
    polypeptide ENSMUSP00000028764 Ensembl | MGI Sequence Detail 125 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 12
      cDNA 10
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13095, MGD-MRK-13096
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 29
      Gene Ontology 6
      Phenotypes 79
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:268467 Ates T, et al., Inactivation of Magel2 suppresses oxytocin neurons through synaptic excitation-inhibition imbalance. Neurobiol Dis. 2019 Jan;121:58-64

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory