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Otx1
Gene Detail
Symbol

Name
ID
Otx1
orthodenticle homolog 1
MGI:97450
Synonyms
A730044F23Rik, jv
Feature Type
protein coding gene
Genetic Map
Chromosome 11
14.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:21994764-22002897 bp, - strand
From VEGA annotation of GRCm38

  8134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Otx1

Human
homologs
Human Homolog OTX1, orthodenticle homeobox 1
NCBI Gene ID 5013
neXtProt AC  NX_P32242
Human Chr (Location)  2p13; chr2:63050057-63057831 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Spontaneous(1) Targeted(6)
Incidental mutations (data from APF )
 
Inner ear abnormalities and circling/head-shaking behavior are seen in mild mutants; null mutants also have spontaneous seizures and defects in dorsal telencephalic cortex, mesencephalon, cerebellum and eye; and show delayed growth and sexual maturation.
 
Interactions
Otx1 interacts with 226 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process anterior/posterior pattern specification, diencephalon morphogenesis, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (117 records)
Data Summary: Results (612)    Tissues (279)    Images (128)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 537
Western blot 3
RT-PCR 68
RNase protection 2
cDNA source data(29)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) Genomic(5) cDNA(30) Primer pair(11) Other(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005253 (Evidence)
Ensembl Gene ModelENSMUSG00000005917 (Evidence)
Entrez Gene18423 (Evidence)
UniGene129663
DFCITC1581913, TC1605378
DoTSDT.101703546, DT.40157212
NIA Mouse Gene IndexU041128
Consensus CDS ProjectCCDS24468.1
International Mouse Knockout Project StatusOtx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005253 VEGA Gene Model | MGI Sequence Detail 8134 C57BL/6J ±  kb
transcript OTTMUST00000011716 VEGA | MGI Sequence Detail 2789 Not Applicable 
polypeptide OTTMUSP00000005430 VEGA | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(7)
Polymorphisms
PCR(1) : SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003025 Transcription factor Otx
InterPro IPR003026 Transcription factor Otx1
InterPro IPR013851 Transcription factor Otx, C-terminal
Protein Ontology PR:000012085 homeobox protein OTX1
References
(Earliest) J:13457 Dickie MM, et al., [Jackson waltzer, jv.]. Mouse News Lett. 1966;35:31
(Latest) J:206224 Dixit R, et al., Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation. Gene Expr Patterns. 2014 Jan;14(1):42-54
All references(186)
Other
accession IDs
MGD-MRK-11545, MGD-MRK-13086, MGI:2444751, MGI:96651

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory