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Osbp Gene Detail
Summary
  • Symbol
    Osbp
  • Name
    oxysterol binding protein
  • Synonyms
    1110018F06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:97447
    NCBI Gene: 76303
  • Gene Overview
    MyGene.info: OSBP
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11965844-11994105 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 8.58 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97447
protein coding gene Chr19:11965844-11994114 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024890
protein coding gene Chr19:9367420-9397668 (+)
A/J MGP_AJ_G0024866
protein coding gene Chr19:8847661-8876282 (+)
AKR/J MGP_AKRJ_G0024839
protein coding gene Chr19:9183367-9211556 (+)
BALB/cJ MGP_BALBcJ_G0024866
protein coding gene Chr19:8853896-8881870 (+)
C3H/HeJ MGP_C3HHeJ_G0024630
protein coding gene Chr19:9079689-9109134 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025314
protein coding gene Chr19:9849999-9892077 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022740
protein coding gene Chr19:9430363-9458878 (+)
CAST/EiJ MGP_CASTEiJ_G0024103
protein coding gene Chr19:8685882-8713783 (+)
CBA/J MGP_CBAJ_G0024605
protein coding gene Chr19:9908874-9939669 (+)
DBA/2J MGP_DBA2J_G0024733
protein coding gene Chr19:8811757-8839480 (+)
FVB/NJ MGP_FVBNJ_G0024698
protein coding gene Chr19:8842489-8870475 (+)
LP/J MGP_LPJ_G0024820
protein coding gene Chr19:9379305-9409037 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024725
protein coding gene Chr19:9812734-9841581 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025362
protein coding gene Chr19:9166570-9196894 (+)
PWK/PhJ MGP_PWKPhJ_G0023848
protein coding gene Chr19:8283446-8311353 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023653
protein coding gene Chr19:8350804-8378888 (+)
WSB/EiJ MGP_WSBEiJ_G0024165
protein coding gene Chr19:9027352-9057752 (+)



Homology
more
  • Human Ortholog
    OSBP, oxysterol binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OSBP, oxysterol binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OSBP1
  • Links
    NCBI Gene ID: 5007
    neXtProt AC: NX_P22059
    UniProt: P22059

  • Chr Location
    11q12.1; chr11:59574398-59616144 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 97668
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OSBP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024687 Ensembl Gene Model | MGI Sequence Detail 28262 C57BL/6J ±  kb
transcript ENSMUST00000025590 Ensembl | MGI Sequence Detail 4578 Not Applicable  
polypeptide ENSMUSP00000025590 Ensembl | MGI Sequence Detail 805 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13055, MGI:1923553, MGI:2147753
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:10477 Levanon D, et al., cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19. Genomics. 1990 May;7(1):65-74
  • Latest
    J:261440 Sobajima T, et al., The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution. J Cell Biol. 2018 May 7;217(5):1777-1796

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory