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Oprl1
Gene Detail
 Symbol
Name
ID
Oprl1
opioid receptor-like 1
MGI:97440
Synonyms LC132, morc, MOR-C, nociceptin/ orphaninFQ receptor, N/OFQ receptor, ORL1, XOR1
Feature Type protein coding gene
Genetic Map
Chromosome 2
103.74 cM, cytoband H2-4
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:181715016-181720985 bp, + strand
From VEGA annotation of GRCm38

  5970 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22609  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: opioid receptor
Gene Tree: Oprl1

Human
homologs
Human Homolog OPRL1, opiate receptor-like 1
NCBI Gene ID 4987
neXtProt AC  NX_P41146
Human Synonyms  KOR-3, NOCIR, OOR, ORL1
Human Chr (Location)  20q13.33; chr20:64080098-64100643 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for a null allele exhibit altered touch/nociception, facilitation of long-term potentiation and memory, increased dopamine release upon administration of opioid peptide agonist, impaired behavioral response to morphine, and increased susceptibility to noise-induced hearing loss.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, behavior, ...
Component cytoplasmic vesicle, integral component of membrane, ...
Function G-protein coupled receptor activity, nociceptin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (516)    Tissues (125)    Images (33)
Theiler Stages: 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 338
RT-PCR 178
cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(39) Genomic(7) cDNA(28) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016806 (Evidence)
Ensembl Gene ModelENSMUSG00000027584 (Evidence)
Entrez Gene18389 (Evidence)
UniGene285075
DFCITC1575997, TC1592157, TC1594903, TC1596740, TC1630174, TC1661530, TC1778241
DoTSDT.101378315, DT.101378321, DT.101735929, DT.101735930, DT.55242438, DT.87051013, DT.94346969, DT.94350666
NIA Mouse Gene IndexU002991
Consensus CDS ProjectCCDS17222.1
International Mouse Knockout Project StatusOprl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016806 VEGA Gene Model | MGI Sequence Detail 5970 C57BL/6J ±  kb
transcript OTTMUST00000040818 VEGA | MGI Sequence Detail 1248 Not Applicable 
polypeptide OTTMUSP00000018253 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(109) RefSeq(13) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001418 Opioid receptor
InterPro IPR001420 X opioid receptor
Protein Ontology PR:000001631 nociceptin receptor
References (Earliest) J:17330 Mollereau C, et al., ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. FEBS Lett. 1994 Mar 14;341(1):33-8
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(81)
Other
accession IDs
MGD-MRK-13040

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory