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Oprl1
Gene Detail
Symbol

Name
ID
Oprl1
opioid receptor-like 1
MGI:97440
Synonyms
LC132, morc, MOR-C, nociceptin/ orphaninFQ receptor, N/OFQ receptor, ORL1, XOR1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
103.74 cM, cytoband H2-4
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:181715016-181720985 bp, + strand
From VEGA annotation of GRCm38

  5970 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22609  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: OPRL1
Protein SuperFamily: opioid receptor
Gene Tree: Oprl1

Human
homologs
OPRL1, opiate receptor-like 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4987
neXtProt AC: NX_P41146

Human Synonyms: KOR-3, NOCIR, OOR, ORL1

Human Chr (Location): 20q13.33; chr20:64080118-64100643 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit altered touch/nociception, facilitation of long-term potentiation and memory, increased dopamine release upon administration of opioid peptide agonist, impaired behavioral response to morphine, and increased susceptibility to noise-induced hearing loss.
 
Interactions
Oprl1 interacts with 249 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (516)    Tissues (125)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 338
RT-PCR 178
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN oprl1    NEW 
Molecular
reagents
All nucleic(39) Genomic(7) cDNA(28) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016806 (Evidence)
Ensembl Gene Model ENSMUSG00000027584 (Evidence)
Entrez Gene 18389 (Evidence)
UniGene 285075
DFCI TC1575997, TC1592157, TC1594903, TC1596740, TC1630174, TC1661530, TC1778241
DoTS DT.101378315, DT.101378321, DT.101735929, DT.101735930, DT.55242438, DT.87051013, DT.94346969, DT.94350666
NIA Mouse Gene Index U002991
Consensus CDS Project CCDS17222.1
International Mouse Phenotyping Consortium Status Oprl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016806 VEGA Gene Model | MGI Sequence Detail 5970 C57BL/6J ±  kb
transcript OTTMUST00000040810 VEGA | MGI Sequence Detail 2999 Not Applicable 
polypeptide OTTMUSP00000018249 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(109) RefSeq(13) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001418 Opioid receptor
InterPro IPR001420 X opioid receptor
Protein Ontology PR:000001631 nociceptin receptor
References
(Earliest) J:17330 Mollereau C, et al., ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. FEBS Lett. 1994 Mar 14;341(1):33-8
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(81)
Other
accession IDs
MGD-MRK-13040

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory