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Oprl1 Gene Detail
Summary
  • Symbol
    Oprl1
  • Name
    opioid receptor-like 1
  • Synonyms
    LC132, morc, MOR-C, nociceptin/ orphaninFQ receptor, N/OFQ receptor, NOP, ORL1, XOR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97440
    NCBI Gene: 18389
  • Gene Overview
    MyGene.info: OPRL1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:181715016-181720985 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 103.74 cM, cytoband H2-4
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97440
protein coding gene Chr2:181714984-181720985 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027036
protein coding gene Chr2:188341102-188347071 (+)
A/J MGP_AJ_G0027002
protein coding gene Chr2:180571493-180577471 (+)
AKR/J MGP_AKRJ_G0026972
protein coding gene Chr2:185990871-185996849 (+)
BALB/cJ MGP_BALBcJ_G0027010
protein coding gene Chr2:181051712-181057681 (+)
C3H/HeJ MGP_C3HHeJ_G0026752
protein coding gene Chr2:186333677-186339655 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027456
protein coding gene Chr2:193779764-193785733 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024820
protein coding gene Chr2:171252716-171258680 (+)
CAST/EiJ MGP_CASTEiJ_G0026211
protein coding gene Chr2:184614427-184620388 (+)
CBA/J MGP_CBAJ_G0026729
protein coding gene Chr2:200804755-200810724 (+)
DBA/2J MGP_DBA2J_G0026866
protein coding gene Chr2:179674114-179680092 (+)
FVB/NJ MGP_FVBNJ_G0026832
protein coding gene Chr2:178293682-178299651 (+)
LP/J MGP_LPJ_G0026968
protein coding gene Chr2:188357087-188363056 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026852
protein coding gene Chr2:203351662-203357631 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027516
protein coding gene Chr2:185967215-185973184 (+)
PWK/PhJ MGP_PWKPhJ_G0025947
protein coding gene Chr2:177203540-177209513 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025747
protein coding gene Chr2:182454990-182460948 (+)
WSB/EiJ MGP_WSBEiJ_G0026283
protein coding gene Chr2:186948483-186954459 (+)



Homology
more
  • Human Ortholog
    OPRL1, opioid related nociceptin receptor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    OPRL1, opioid related nociceptin receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KOR-3, NOCIR, NOP, NOPr, OOR, ORL1
  • Links
    NCBI Gene ID: 4987
    neXtProt AC: NX_P41146
    UniProt: P41146

  • Chr Location
    20q13.33; chr20:64080082-64100643 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit altered touch/nociception, facilitation of long-term potentiation and memory, increased dopamine release upon administration of opioid peptide agonist, impaired behavioral response to morphine, and increased susceptibility to noise-induced hearing loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027584 Ensembl Gene Model | MGI Sequence Detail 5970 C57BL/6J ±  kb
transcript ENSMUST00000071585 Ensembl | MGI Sequence Detail 2999 Not Applicable  
polypeptide ENSMUSP00000071513 Ensembl | MGI Sequence Detail 367 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    Genomic 7
    cDNA 29
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13040
References
more
  • Summaries
    All 86
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 34
  • Earliest
    J:17330 Mollereau C, et al., ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. FEBS Lett. 1994 Mar 14;341(1):33-8
  • Latest
    J:230870 Arcuri L, et al., Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease. Neurobiol Dis. 2016 May;89:55-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory