Oprl1
Gene Detail

Symbol Name ID

Oprl1 opioid receptor-like 1 MGI:97440

Synonyms

LC132, morc, MOR-C, nociceptin/ orphaninFQ receptor, N/OFQ receptor, ORL1, XOR1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

103.74 cM, cytoband H2-4
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr2:181715016-181720985 bp, + strand From VEGA annotation of GRCm38   5970 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic; guinea pig    (Mammalian Orthology)
Comparative Map (Mouse/Human Oprl1 ± 2 cM)

Protein SuperFamily: opioid receptor
Gene Tree: Oprl1

Human ortholog

OPRL1 opiate receptor-like 1 NCBI Gene ID 4987
Human Synonyms: KOR-3, NOCIR, OOR, ORL1
Human Chr20:62711488-62731996 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null allele exhibit altered touch/nociception, facilitation of long-term potentiation and memory, increased dopamine release upon administration of opioid peptide agonist, impaired behavioral response to morphine, and increased susceptibility to noise-induced hearing loss.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	elevation of cytosolic calcium ion concentration, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, nociceptin receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (516)    Tissues (125)    Images (33)
Theiler Stages: 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	338
RT-PCR	178

cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(49) Genomic(7) cDNA(38) Primer pair(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016806 (Evidence)
Ensembl Gene Model	ENSMUSG00000027584 (Evidence)
Entrez Gene	18389 (Evidence)
UniGene	285075
DFCI	TC1575997, TC1592157, TC1594903, TC1596740, TC1630174, TC1661530, TC1778241
DoTS	DT.101378315, DT.101378321, DT.101735929, DT.101735930, DT.55242438, DT.87051013, DT.94346969, DT.94350666
NIA Mouse Gene Index	U002991
Consensus CDS Project	CCDS17222.1
International Mouse Knockout Project Status	Oprl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016806	VEGA Gene Model | MGI Sequence Detail	5970	C57BL/6J
transcript	OTTMUST00000040810	VEGA | MGI Sequence Detail	2999	Not Applicable
polypeptide	OTTMUSP00000018249	VEGA | MGI Sequence Detail	367	Not Applicable

All sequences(96) RefSeq(7) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(78 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR001418	Opioid receptor
InterPro	IPR001420	X opioid receptor
Protein Ontology	PR:000001631	nociceptin receptor

References

(Earliest) J:17330 Mollereau C, et al., ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. FEBS Lett. 1994 Mar 14;341(1):33-8
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(81)

Other accession IDs

MGD-MRK-13040