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Oprd1
Gene Detail
Symbol

Name
ID
Oprd1
opioid receptor, delta 1
MGI:97438
Synonyms
DOR, DOR-1, mDOR, Nbor
Feature Type
protein coding gene
Genetic Map
Chromosome 4
64.78 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr4:132110726-132144486 bp, - strand
From VEGA annotation of GRCm38

  33761 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: OPRD1
Protein SuperFamily: opioid receptor
Gene Tree: Oprd1

Human
homologs
OPRD1, opioid receptor, delta 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4985
neXtProt AC: NX_P41143

Human Synonyms: OPRD

Human Chr (Location): 1p36.1-p34.3; chr1:28812142-28863696 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(10) Targeted(9)
Genomic Mutations involving Oprd1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one knock-out allele do not develop analgesic tolerance to morphine while mice homozygous for a different knock-out allele exhibit hyperactivity, increased anxiety, and decreased coping response.
 
Interactions
Oprd1 interacts with 237 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (149)    Tissues (76)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
In situ reporter (knock in) 50
RT-PCR 84
cDNA source data(15)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase oprd1 ; ZFIN oprd1a, oprd1b    NEW 
Molecular
reagents
All nucleic(23) Genomic(5) cDNA(16) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010973 (Evidence)
Ensembl Gene Model ENSMUSG00000050511 (Evidence)
Entrez Gene 18386 (Evidence)
UniGene 5243
DFCI TC1587580
DoTS DT.55164271
NIA Mouse Gene Index U025589
PDB 4EJ4
Consensus CDS Project CCDS18718.1
International Mouse Phenotyping Consortium Status Oprd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010973 VEGA Gene Model | MGI Sequence Detail 33761 C57BL/6J ±  kb
transcript OTTMUST00000025727 VEGA | MGI Sequence Detail 4021 Not Applicable 
polypeptide OTTMUSP00000011796 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(503 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000321 Delta opioid receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001418 Opioid receptor
Protein Ontology PR:000001579 delta-type opioid receptor
References
(Earliest) J:14060 Evans CJ, et al., Cloning of a delta opioid receptor by functional expression [see comments]. Science. 1992 Dec 18;258(5090):1952-5
(Latest) J:217940 Neumann C, et al., The delta-Opioid Receptor Affects Epidermal Homeostasis via ERK-Dependent Inhibition of Transcription Factor POU2F3. J Invest Dermatol. 2015 Feb;135(2):471-80
All references(121)
Other
accession IDs
MGD-MRK-12783, MGD-MRK-13038

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory