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Oprd1
Gene Detail
 Symbol
Name
ID
Oprd1
opioid receptor, delta 1
MGI:97438
Synonyms DOR, DOR-1, mDOR, Nbor
Feature Type protein coding gene
Genetic Map
Chromosome 4
64.78 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(22)
Sequence Map
Chr4:132110726-132144486 bp, - strand
From VEGA annotation of GRCm38

  33761 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: opioid receptor
Gene Tree: Oprd1

Human
homologs
Human Homolog OPRD1, opioid receptor, delta 1
NCBI Gene ID 4985
neXtProt AC  NX_P41143
Human Synonyms  OPRD
Human Chr (Location)  1p36.1-p34.3; chr1:28812142-28863696 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(10) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele do not develop analgesic tolerance to morphine while mice homozygous for a different knock-out allele exhibit hyperactivity, increased anxiety, and decreased coping response.
 
Interactions
Oprd1 interacts with 238 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, adult locomotory behavior, ...
Component axon terminus, cytoplasm, ...
Function enkephalin receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (149)    Tissues (76)    Images (7)
Theiler Stages: 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 15
In situ reporter (knock in) 50
RT-PCR 84
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(5) cDNA(16) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010973 (Evidence)
Ensembl Gene ModelENSMUSG00000050511 (Evidence)
Entrez Gene18386 (Evidence)
UniGene5243
DFCITC1587580
DoTSDT.55164271
NIA Mouse Gene IndexU025589
PDB4EJ4
Consensus CDS ProjectCCDS18718.1
International Mouse Knockout Project StatusOprd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010973 VEGA Gene Model | MGI Sequence Detail 33761 C57BL/6J ±  kb
transcript OTTMUST00000025727 VEGA | MGI Sequence Detail 4021 Not Applicable 
polypeptide OTTMUSP00000011796 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(3)
Polymorphisms RFLP(3) : SNPs within 2kb(503 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000321 Delta opioid receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001418 Opioid receptor
Protein Ontology PR:000001579 delta-type opioid receptor
References (Earliest) J:14060 Evans CJ, et al., Cloning of a delta opioid receptor by functional expression [see comments]. Science. 1992 Dec 18;258(5090):1952-5
(Latest) J:208268 Kaneko K, et al., delta-Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72
All references(120)
Other
accession IDs
MGD-MRK-12783, MGD-MRK-13038

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory