Oprd1
Gene Detail

Symbol Name ID

Oprd1 opioid receptor, delta 1 MGI:97438

Synonyms

DOR-1, mDOR, Nbor

Feature Type

protein coding gene

Genetic Map

Chromosome 4

64.78 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(22)

Sequence Map

Chr4:132110726-132144486 bp, - strand From VEGA annotation of GRCm38   33761 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Oprd1 ± 2 cM)

Protein SuperFamily: opioid receptor
Gene Tree: Oprd1

Human ortholog

OPRD1 opioid receptor, delta 1 NCBI Gene ID 4985
Human Synonyms: OPRD
Human Chr1:29138654-29190208 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(16) : Targeted(6) Gene trapped(10)
 

Mice homozygous for one knock-out allele do not develop analgesic tolerance to morphine while mice homozygous for a different knock-out allele exhibit hyperactivity, increased anxiety, and decreased coping response.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, adult locomotory behavior, ...
Component	axon terminus, cytoplasm, ...
Function	enkephalin receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (149)    Tissues (75)    Images (7)
Theiler Stages: 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	15
In situ reporter (knock in)	50
RT-PCR	84

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(5) cDNA(16) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000010973 (Evidence)
Ensembl Gene Model	ENSMUSG00000050511 (Evidence)
Entrez Gene	18386 (Evidence)
UniGene	5243
DFCI	TC1587580
DoTS	DT.55164271
NIA Mouse Gene Index	U025589
PDB	4EJ4
Consensus CDS Project	CCDS18718.1
International Mouse Knockout Project Status	Oprd1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010973	VEGA Gene Model | MGI Sequence Detail	33761	C57BL/6J
transcript	OTTMUST00000025727	VEGA | MGI Sequence Detail	4021	Not Applicable
polypeptide	OTTMUSP00000011796	VEGA | MGI Sequence Detail	372	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(221 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000321	Delta opioid receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR001418	Opioid receptor
Protein Ontology	PR:000001579	delta-type opioid receptor

References

(Earliest) J:14060 Evans CJ, et al., Cloning of a delta opioid receptor by functional expression [see comments]. Science. 1992 Dec 18;258(5090):1952-5
(Latest) J:192510 Erbs E, et al., Distribution of delta opioid receptor-expressing neurons in the mouse hippocampus. Neuroscience. 2012 Sep 27;221:203-13
All references(113)

Other accession IDs

MGD-MRK-12783, MGD-MRK-13038