Oas1b MGI Mouse Pseudogene Detail - MGI:97430 - 2'-5' oligoadenylate synthetase 1B

Symbol

Oas1b
Name

2'-5' oligoadenylate synthetase 1B
Synonyms

Flavivirus resistance, Flv, L1, Mmu-L1, Oias-2, Oias2, Wnv

Feature Type

polymorphic pseudogene

BioType Conflict
IDs

MGI:97430
NCBI Gene: 23961
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr5:120950700-120962228 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 60.64 cM, cytoband F
Mapping Data

12 experiments

SNPs within 2kb

447 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97430	polymorphic pseudogene	Chr5:120950700-120962228 (+)
129S1/SvImJ	ENSMUSG00200023246	protein coding gene	Chr5:114689945-114701471 (+)
A/J	ENSMUSG00195010911	protein coding gene	Chr5:114211130-114222656 (+)
AKR/J	ENSMUSG00220044790	protein coding gene	Chr5:113712077-113723603 (+)
BALB/cJ	ENSMUSG00180030478	protein coding gene	Chr5:114325726-114337252 (+)
C3H/HeJ	ENSMUSG00175028016	protein coding gene	Chr5:116323790-116335317 (+)
C57BL/6NJ	ENSMUSG00215043088	protein coding gene	Chr5:114357639-114369164 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005040308	protein coding gene	Chr5:113529553-113541394 (+)
CBA/J	ENSMUSG00210007318	protein coding gene	Chr5:115074671-115086197 (+)
DBA/2J	ENSMUSG00185053291	protein coding gene	Chr5:118133976-118145500 (+)
FVB/NJ	ENSMUSG00205042410	protein coding gene	Chr5:113987789-113999318 (+)
JF1/MsJ	ENSUMUG00000049083	protein coding gene	Chr5:120969796-120981611 (+)
LP/J	ENSMUSG00230039049	protein coding gene	Chr5:122212141-122223667 (+)
NOD/ShiLtJ	ENSMUSG00190024817	protein coding gene	Chr5:114021856-114033382 (+)
NZO/HlLtJ	ENSMUSG00225014093	protein coding gene	Chr5:129889257-129900781 (+)
PWK/PhJ	ENSLUMG00010030173	protein coding gene	Chr5:112872579-112884423 (+)
SPRET/EiJ	ENSMSPG00010034249	protein coding gene	Chr5:116194599-116206174 (+)
WSB/EiJ	ENSIUOG00005015487	protein coding gene	Chr5:116710232-116722075 (+)

Human Ortholog

OAS1, 2'-5'-oligoadenylate synthetase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OAS1, 2'-5'-oligoadenylate synthetase 1
Synonyms

E18/E16, IFI-4, IMD100, OIAS, OIASI
Links

HGNC:8086

NCBI Gene ID: 4938

UniProt: P00973
Chr Location

12q24.13; chr12:112905856-112933219 (+) GRCh38

MGI Vertebrate Homology

Oas1b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: OAS1
Gene Tree

Oas1b

Diseases

1 with human OAS1 associations

				Human Disease	Mouse Models
				immunodeficiency 100 IDs immunodeficiency 100 DOID:0061070 OMIM:618042

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 4 alleles in 4 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Spontaneous

3
Targeted

2
Genomic Mutations

3 involving Oas1b
Find Mice (IMSR)

15 strains or lines available

Spontaneous mutations of this gene result in altered susceptibility to viral infection.

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All GO Annotations

49
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

598
Tissues

1
cDNA Data

20
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

48
RefSeq

3
UniProt

6

Ensembl

ENSMUSG00000029605 (Evidence)
NCBI Gene

23961

			Length	Strain/Species	Flank
genomic	23961	NCBI Gene Model \| MGI Sequence Detail	11529	C57BL/6J	± kb
transcript	NR_003507	RefSeq \| MGI Sequence Detail	1848	ZRU/MplStud
polypeptide	Q60856	UniProt \| EBI \| MGI Sequence Detail	376	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000012102 2'-5'-oligoadenylate synthetase 1B

(term hierarchy)
InterPro Domains

IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal

IPR006117 2-5-oligoadenylate synthetase, C-terminal conserved site

IPR043519 Nucleotidyltransferase superfamily

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All nucleic 27

Genomic 5

cDNA 21

Primer pair 1

Microarray probesets 3

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MGD-MRK-13024, MGD-MRK-13026, MGD-MRK-9840, MGI:2388353, MGI:95562

Summaries

All 71

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 26
Earliest

J:13005 Webster LT, INHERITANCE OF RESISTANCE OF MICE TO ENTERIC BACTERIAL AND NEUROTROPIC VIRUS INFECTIONS. J Exp Med. 1937 Jan 31;65(2):261-86
Latest

J:391151 Harioudh MK, et al., The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation. Immunity. 2024 Jun 24;

TSS for Oas1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48545	Chr5:120950690-120950733 (+)	12 bp
Tssr48546	Chr5:120950738-120950749 (+)	44 bp
Tssr48547	Chr5:120950944-120950949 (+)	247 bp
Tssr48548	Chr5:120951779-120951793 (+)	1,086 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24