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Oas1b Pseudogene Detail
Summary
  • Symbol
    Oas1b
  • Name
    2'-5' oligoadenylate synthetase 1B
  • Synonyms
    Flavivirus resistance, Flv, L1, Mmu-L1, Oias2, Oias-2, Wnv
  • Feature Type
    polymorphic pseudogene
  • IDs
    MGI:97430
    NCBI Gene: 23961
  • Gene Overview
    MyGene.info: OAS1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:120812635-120824163 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 60.64 cM, cytoband F
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97430
polymorphic pseudogene Chr5:120812635-120824163 (+)
129S1/SvImJ MGP_129S1SvImJ_G0009946
polymorphic pseudogene Chr5:124230644-124242178 (+)
A/J MGP_AJ_G0009931
polymorphic pseudogene Chr5:119063066-119078947 (+)
AKR/J MGP_AKRJ_G0009914
polymorphic pseudogene Chr5:122928374-122941391 (+)
BALB/cJ MGP_BALBcJ_G0009914
polymorphic pseudogene Chr5:120479125-120490656 (+)
C3H/HeJ MGP_C3HHeJ_G0009847
polymorphic pseudogene Chr5:123484313-123507596 (+)
C57BL/6NJ MGP_C57BL6NJ_G0010164
polymorphic pseudogene Chr5:128885953-128911660 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0009665
polymorphic pseudogene Chr5:122569920-122624466 (+)
CBA/J MGP_CBAJ_G0009821
polymorphic pseudogene Chr5:133927843-133949805 (+)
DBA/2J MGP_DBA2J_G0009848
polymorphic pseudogene Chr5:119167529-119179372 (+)
FVB/NJ MGP_FVBNJ_G0009867
polymorphic pseudogene Chr5:118104727-118119040 (+)
LP/J MGP_LPJ_G0009943
polymorphic pseudogene Chr5:124691136-124714316 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0009833
polymorphic pseudogene Chr5:137866705-137878049 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0010135
polymorphic pseudogene Chr5:122494530-122506060 (+)
PWK/PhJ MGP_PWKPhJ_G0009585
polymorphic pseudogene Chr5:117934627-117945488 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0009768
polymorphic pseudogene Chr5:123082558-123113793 (+)



Homology
more
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
    Orthology source: HGNC
  • Synonyms
    E18/E16, IFI-4, OIAS, OIASI
  • Links
    NCBI Gene ID: 4938
    neXtProt AC: NX_P00973
    UniProt: P00973

  • Chr Location
    12q24.13; chr12:112906777-112932190 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 4 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    3
  • Targeted
    1
  • Genomic Mutations
    2 involving Oas1b
  • Find Mice (IMSR)
Spontaneous mutations of this gene result in altered susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic 23961 NCBI Gene Model | MGI Sequence Detail 11529 C57BL/6J ±  kb
transcript NR_003507 RefSeq | MGI Sequence Detail 1848 C57BL/6  
polypeptide Q60856 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000012102 2'-5'-oligoadenylate synthetase 1B
  • InterPro Domains
    IPR026774 2'-5'-oligoadenylate synthase
    IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
    IPR006117 2-5-oligoadenylate synthetase, conserved site
    IPR038121 2'-5'-oligoadenylate synthetase, domain 2 superfamily
    IPR006116 2-5-oligoadenylate synthetase, N-terminal
    IPR002934 Polymerase, nucleotidyl transferase domain
Molecular
Reagents
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  • All nucleic 26
    Genomic 5
    cDNA 21

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13024, MGD-MRK-13026, MGD-MRK-9840, MGI:2388353, MGI:95562
References
more
  • Summaries
    All 55
    Gene Ontology 2
    Phenotypes 21
  • Earliest
    J:13005 Webster LT, Inheritance of resistance of mice to enteric bacterial and neurotropic virus infection. J Exp Med. 1937;65:261-286
  • Latest
    J:271478 Green R, et al., Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross. G3 (Bethesda). 2017 Jun 7;7(6):1665-1682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory