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Ocm Gene Detail
Summary
  • Symbol
    Ocm
  • Name
    oncomodulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:97401
    NCBI Gene: 18261
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:143956622-143963488 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 82.85 cM, cytoband G1-3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97401
protein coding gene Chr5:143956615-143987691 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030344
protein coding gene Chr5:149330692-149338105 (-)
A/J MGP_AJ_G0030313
protein coding gene Chr5:142927154-142934701 (-)
AKR/J MGP_AKRJ_G0030245
protein coding gene Chr5:147377349-147385243 (-)
BALB/cJ MGP_BALBcJ_G0030330
protein coding gene Chr5:144157969-144164923 (-)
C3H/HeJ MGP_C3HHeJ_G0030041
protein coding gene Chr5:148219600-148226466 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030775
protein coding gene Chr5:154794017-154801039 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027994
protein coding gene Chr5:136712151-136718547 (-)
CAST/EiJ MGP_CASTEiJ_G0029446
protein coding gene Chr5:147738450-147745128 (-)
CBA/J MGP_CBAJ_G0030011
protein coding gene Chr5:161150506-161157342 (-)
DBA/2J MGP_DBA2J_G0030161
protein coding gene Chr5:142678136-142685002 (-)
FVB/NJ MGP_FVBNJ_G0030116
protein coding gene Chr5:141885065-141892346 (-)
LP/J MGP_LPJ_G0030247
protein coding gene Chr5:149939690-149947620 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030147
protein coding gene Chr5:163530271-163537212 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030815
protein coding gene Chr5:147262939-147269805 (-)
PWK/PhJ MGP_PWKPhJ_G0029161
protein coding gene Chr5:141779826-141786679 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028997
protein coding gene Chr5:145002666-145012440 (-)
WSB/EiJ MGP_WSBEiJ_G0029519
protein coding gene Chr5:148071812-148078678 (-)



Homology
more
  • Human Ortholog
    OCM, oncomodulin
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OCM, oncomodulin
  • Synonyms
    OCM1, OM, ONCM
  • Links
    NCBI Gene ID: 654231
    neXtProt AC: NX_P0CE72
    UniProt: P0CE72

  • Chr Location
    chr7:5859718-5886363 (+)  GRCh38

  • Human Ortholog
    OCM2, oncomodulin 2
  • Synonyms
    OCM, OM
  • Links
    NCBI Gene ID: 4951
    neXtProt AC: NX_P0CE71
    UniProt: P0CE71

  • Chr Location
    7q21.3; chr7:97984687-97991169 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit deafness and degeneration of inner and outer cochlear hair cells and pillar cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029618 Ensembl Gene Model | MGI Sequence Detail 6867 C57BL/6J ±  kb
transcript ENSMUST00000031622 Ensembl | MGI Sequence Detail 658 Not Applicable  
polypeptide ENSMUSP00000031622 Ensembl | MGI Sequence Detail 109 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 9
    cDNA 3
    Primer pair 2
    Other 6

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-12973
References
more
  • Summaries
    All 53
    Developmental Gene Expression 20
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:16027 Banville D, et al., Retroviral long terminal repeat is the promoter of the gene encoding the tumor-associated calcium-binding protein oncomodulin in the rat. J Mol Biol. 1989 Jun 5;207(3):481-90
  • Latest
    J:343188 Yang Y, et al., Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells. J Physiol. 2023 Oct;601(19):4291-4308

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory