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Slc10a1
Gene Detail
 Symbol
Name
ID
Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
MGI:97379
Synonyms Ntcp, sodium bile acid cotransporting polypeptide
Feature Type protein coding gene
Genetic Map
Chromosome 12
37.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:80953185-80968079 bp, - strand
From NCBI annotation of GRCm38

  14895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: sodium-dependent transporter
Gene Tree: Slc10a1

Human
homologs
Human Homolog SLC10A1, solute carrier family 10 (sodium/bile acid cotransporter), member 1
NCBI Gene ID 6554
neXtProt AC  NX_Q14973
Human Synonyms  NTCP
Human Chr (Location)  14q24.1; chr14:69775835-69797289 (-)  GRCh38
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Slc10a1 interacts with 104 markers (Mir1b, Mir7-1, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process bile acid and bile salt transport, ion transport, ...
Component basolateral plasma membrane, integral component of membrane, ...
Function bile acid:sodium symporter activity, bile acid transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23
Assay TypeResults
RNA in situ 1
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(20) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000021135 (Evidence)
Entrez Gene20493 (Evidence)
UniGene486361
DFCITC1584031
DoTSDT.40149104, DT.97410737
NIA Mouse Gene IndexU034133
Consensus CDS ProjectCCDS49101.1
International Mouse Knockout Project StatusSlc10a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20493 NCBI Gene Model | MGI Sequence Detail 14895 C57BL/6J ±  kb
transcript NM_001177561 RefSeq | MGI Sequence Detail 1674 C57BL/6 
polypeptide O08705 UniProt | EBI | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(6) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002657 Bile acid:sodium symporter
InterPro IPR004710 Bile acid transporter
Protein Ontology PR:000014917 sodium/bile acid cotransporter
Graphical View of Protein Domain Structure
References (Earliest) J:692 Hagenbuch B, et al., Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10629-33
(Latest) J:185731 Cui JY, et al., RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Toxicol Sci. 2012 Jun;127(2):592-608
All references(33)
Other
accession IDs
MGD-MRK-12936

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory