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Slc10a1 Gene Detail
Summary
  • Symbol
    Slc10a1
  • Name
    solute carrier family 10 (sodium/bile acid cotransporter family), member 1
  • Synonyms
    Ntcp, sodium bile acid cotransporting polypeptide
  • Feature Type
    protein coding gene
  • IDs
    MGI:97379
    NCBI Gene: 20493
  • Gene Overview
    MyGene.info: SLC10A1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:80953185-80968700 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 37.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97379
protein coding gene Chr12:80953183-80968705 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019896
protein coding gene Chr12:81377154-81397071 (-)
A/J MGP_AJ_G0019854
protein coding gene Chr12:78398738-78413793 (-)
AKR/J MGP_AKRJ_G0019829
protein coding gene Chr12:80542556-80557288 (-)
BALB/cJ MGP_BALBcJ_G0019833
protein coding gene Chr12:78648086-78663387 (-)
C3H/HeJ MGP_C3HHeJ_G0019639
protein coding gene Chr12:81010425-81025223 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020285
protein coding gene Chr12:83753246-83767933 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017904
protein coding gene Chr12:75389342-75404744 (-)
CAST/EiJ MGP_CASTEiJ_G0019189
protein coding gene Chr12:75882304-75899044 (-)
CBA/J MGP_CBAJ_G0019610
protein coding gene Chr12:87013545-87028228 (-)
DBA/2J MGP_DBA2J_G0019725
protein coding gene Chr12:78008904-78023836 (-)
FVB/NJ MGP_FVBNJ_G0019711
protein coding gene Chr12:76832266-76849423 (-)
LP/J MGP_LPJ_G0019797
protein coding gene Chr12:81283677-81299740 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019750
protein coding gene Chr12:90005827-90023871 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020320
protein coding gene Chr12:80077975-80095829 (-)
PWK/PhJ MGP_PWKPhJ_G0018955
protein coding gene Chr12:72408995-72425521 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018749
protein coding gene Chr12:74589916-74608647 (-)
WSB/EiJ MGP_WSBEiJ_G0019242
protein coding gene Chr12:80714429-80729436 (-)



Homology
more
  • Human Ortholog
    SLC10A1, solute carrier family 10 member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC10A1, solute carrier family 10 member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NTCP
  • Links
    NCBI Gene ID: 6554
    neXtProt AC: NX_Q14973
    UniProt: Q14973

  • Chr Location
    14q24.1; chr14:69775835-69797289 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20493 NCBI Gene Model | MGI Sequence Detail 15516 C57BL/6J ±  kb
transcript NM_001361972 RefSeq | MGI Sequence Detail 1747 C57BL/6  
polypeptide O08705 UniProt | EBI | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 2
    cDNA 20
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-12936
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:692 Hagenbuch B, et al., Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10629-33
  • Latest
    J:263861 Winer BY, et al., Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med. 2018 Jun 27;10(447)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory