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Slc10a1 Gene Detail
Summary
  • Symbol
    Slc10a1
  • Name
    solute carrier family 10 (sodium/bile acid cotransporter family), member 1
  • Synonyms
    Ntcp, sodium bile acid cotransporting polypeptide
  • Feature Type
    protein coding gene
  • IDs
    MGI:97379
    NCBI Gene: 20493
  • Gene Overview
    MyGene.info: SLC10A1
Location & Maps
more
  • Sequence Map
    Chr12:80953185-80968079 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14895 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 37.21 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLC10A1, solute carrier family 10 member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC10A1, solute carrier family 10 member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NTCP
  • Links
    NCBI Gene ID: 6554
    neXtProt AC: NX_Q14973

  • Chr Location
    14q24.1; chr14:69775835-69797289 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    1
  • Chemically induced (other)
    1
  • Genomic Mutations
    1 involving Slc10a1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021135 Ensembl Gene Model | MGI Sequence Detail 14895 C57BL/6J ±  kb
transcript ENSMUST00000095572 Ensembl | MGI Sequence Detail 1674 Not Applicable  
polypeptide ENSMUSP00000093229 Ensembl | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    83 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014917 sodium/bile acid cotransporter
  • InterPro Domains
    IPR004710 Bile acid:sodium symporter
    IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3
    IPR030208 Solute carrier family 10 member 1
Molecular
Reagents
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  • All nucleic 22
    Genomic 1
    cDNA 20
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-12936
References
more
  • Summaries
    All 30
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:692 Hagenbuch B, et al., Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10629-33
  • Latest
    J:222615 Abe K, et al., The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing. EMBO J. 2015 Jun 3;34(11):1523-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory