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Slc10a1
Gene Detail
Symbol

Name
ID
Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
MGI:97379
Synonyms
Ntcp, sodium bile acid cotransporting polypeptide
Feature Type
protein coding gene
Genetic Map
Chromosome 12
37.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:80953185-80968079 bp, - strand
From Ensembl annotation of GRCm38

  14895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sodium-dependent transporter
Gene Tree: Slc10a1

Human
homologs
Human Homolog SLC10A1, solute carrier family 10 (sodium/bile acid cotransporter), member 1
NCBI Gene ID 6554
neXtProt AC  NX_Q14973
Human Synonyms  NTCP
Human Chr (Location)  14q24.1; chr14:69775835-69797289 (-)  GRCh38
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Slc10a1 interacts with 104 markers (Mir1b, Mir7-1, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(20) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000021135 (Evidence)
Entrez Gene20493 (Evidence)
UniGene486361
DFCITC1584031
DoTSDT.97410737, DT.40149104
NIA Mouse Gene IndexU034133
Consensus CDS ProjectCCDS49101.1
International Mouse Knockout Project StatusSlc10a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021135 Ensembl Gene Model | MGI Sequence Detail 14895 C57BL/6J ±  kb
transcript ENSMUST00000095572 Ensembl | MGI Sequence Detail 1674 Not Applicable 
polypeptide ENSMUSP00000093229 Ensembl | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(6) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002657 Bile acid:sodium symporter
InterPro IPR004710 Bile acid transporter
Protein Ontology PR:000014917 sodium/bile acid cotransporter
References
(Earliest) J:692 Hagenbuch B, et al., Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10629-33
(Latest) J:185731 Cui JY, et al., RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Toxicol Sci. 2012 Jun;127(2):592-608
All references(32)
Other
accession IDs
MGD-MRK-12936

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory