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Nppa
Gene Detail
 Symbol
Name
ID
Nppa
natriuretic peptide type A
MGI:97367
STS D4Nds13
Synonyms Anf, ANP, atrial natriuretic peptide, natriuretic peptide precursor A, Pnd
Feature Type protein coding gene
Genetic Map
Chromosome 4
78.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(61)
Sequence Map
Chr4:148000722-148002079 bp, + strand
From VEGA annotation of GRCm38

  1358 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: natriuretic peptide A precursor
Gene Tree: Nppa

Human
homologs
Human Homolog NPPA, natriuretic peptide A
NCBI Gene ID 4878
neXtProt AC  NX_P01160
Human Synonyms  ANF, ANP, ATFB6, CDD-ANF, PND
Human Chr (Location)  1p36.21; chr1:11845709-11847783 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NPPA
Alleles
and
phenotypes
All alleles(4) : Targeted(2) Gene trapped(2)
 
Homozygotes are chronically hypertensive partly due to changes in peripheral resistance and increased central AT1-receptor activation, and show salt-sensitive hypertension and abnormal pulmonary vascular remodeling with increased ventricular mass and muscularization of peripheral pulmonary vessels.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cardiac muscle hypertrophy in response to stress, cGMP biosynthetic process, ...
Component cytoplasm, extracellular region, ...
Function hormone activity, peptide hormone receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (193 records)
Data Summary: Results (163)    Tissues (63)    Images (56)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 93
Northern blot 29
RT-PCR 36
RNase protection 2
cDNA source data(96)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(124) Genomic(8) cDNA(102) Primer pair(13) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010192 (Evidence)
Ensembl Gene ModelENSMUSG00000041616 (Evidence)
Entrez Gene230899 (Evidence)
UniGene482123
DFCITC1577987
DoTSDT.94227687
Consensus CDS ProjectCCDS18927.1
International Mouse Knockout Project StatusNppa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010192 VEGA Gene Model | MGI Sequence Detail 1358 C57BL/6J ±  kb
transcript OTTMUST00000023685 VEGA | MGI Sequence Detail 865 Not Applicable 
polypeptide OTTMUSP00000010827 VEGA | MGI Sequence Detail 152 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(23) : PCR(6) RFLP(17) SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000663 Natriuretic peptide
InterPro IPR002407 Natriuretic peptide, atrial type
Protein Ontology PR:000011374 atrial natriuretic factor
References (Earliest) J:7667 Seidman CE, et al., Nucleotide sequences of the human and mouse atrial natriuretic factor genes. Science. 1984 Dec 7;226(4679):1206-9
(Latest) J:204450 Gavrilov S, et al., Lack of genetic interaction between Tbx20 and Tbx3 in early mouse heart development. PLoS One. 2013;8(7):e70149
All references(320)
Other
accession IDs
MGD-MRK-12921, MGD-MRK-1319, MGD-MRK-13536

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory