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Nppa Gene Detail
Summary
  • Symbol
    Nppa
  • Name
    natriuretic peptide type A
  • Synonyms
    Anf, ANP, atrial natriuretic peptide, natriuretic peptide precursor A, Pnd
  • Feature Type
    protein coding gene
  • IDs
    MGI:97367
    NCBI Gene: 230899
  • Gene Overview
    MyGene.info: NPPA
Location & Maps
more
  • Sequence Map
    Chr4:148000722-148002079 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1358 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.66 cM
  • Mapping Data
    61 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    NPPA, natriuretic peptide A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NPPA, natriuretic peptide A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANF, ANP, ATFB6, ATRST2, CDD, CDD-ANF, CDP, PND
  • Links
    NCBI Gene ID: 4878
    neXtProt AC: NX_P01160

  • Chr Location
    1p36.21; chr1:11845709-11847783 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human NPPA associations

Human Disease Mouse Models
       Atrial Fibrillation, Familial, 6; ATFB6   OMIM: 612201
Atrial Standstill 2; ATRST2   OMIM: 615745
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 2 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Nppa
Homozygotes are chronically hypertensive partly due to changes in peripheral resistance and increased central AT1-receptor activation, and show salt-sensitive hypertension and abnormal pulmonary vascular remodeling with increased ventricular mass and muscularization of peripheral pulmonary vessels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010192 VEGA Gene Model | MGI Sequence Detail 1358 C57BL/6J ±  kb
transcript OTTMUST00000023685 VEGA | MGI Sequence Detail 865 Not Applicable  
polypeptide OTTMUSP00000010827 VEGA | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    47 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011374 atrial natriuretic factor
  • InterPro Domains
    IPR000663 Natriuretic peptide
    IPR002407 Natriuretic peptide, atrial type
    IPR030480 Natriuretic peptide, conserved site
Molecular
Reagents
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  • All nucleic 126
    Genomic 8
    cDNA 102
    Primer pair 15
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12921, MGD-MRK-1319, MGD-MRK-13536
References
more
  • Summaries
    All 334
    Developmental Gene Expression 212
    Gene Ontology 10
    Phenotypes 32
  • Earliest
    J:7667 Seidman CE, et al., Nucleotide sequences of the human and mouse atrial natriuretic factor genes. Science. 1984 Dec 7;226(4679):1206-9
  • Latest
    J:231297 Furtado MB, et al., A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels. Differentiation. 2016 Jan-Mar;91(1-3):29-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory