Mycn
Gene Detail

Symbol Name ID

Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) MGI:97357

Synonyms

bHLHe37, Nmyc, N-myc, Nmyc1, Nmyc-1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

6.14 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(19)

Sequence Map

Chr12:12936096-12941914 bp, - strand From VEGA annotation of GRCm38   5819 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3922  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: myc protein
Gene Tree: Mycn

Human homologs

Human Homolog		MYCN, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
NCBI Gene ID		4613
neXtProt AC		NX_P04198
Human Synonyms		bHLHe37, MODED, N-myc, NMYC, ODED
Human Chr (Location)		2p24.3; chr2:16080683-16087129 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(12) Gene trapped(6)
 

Homozygotes for targeted null mutations exhibit impaired development of the mesonephric tubules, neuroepithelium, sensory ganglia, heart, lung, stomach, and liver. Mutants die around embryonic day 11.5.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	branching morphogenesis of an epithelial tube, cartilage condensation, ...
Component	nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (100 records)
Data Summary: Results (546)    Tissues (232)    Images (84)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	429
Northern blot	80
Western blot	2
RT-PCR	23
RNase protection	2

cDNA source data(52)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(76) Genomic(7) cDNA(56) Primer pair(6) Other(7)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000032640 (Evidence)
Ensembl Gene Model	ENSMUSG00000037169 (Evidence)
Entrez Gene	18109 (Evidence)
UniGene	16469
DFCI	TC1578870, TC1590776
DoTS	DT.101386491, DT.526113
NIA Mouse Gene Index	U033813
Consensus CDS Project	CCDS25818.1
International Mouse Knockout Project Status	Mycn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032640	VEGA Gene Model | MGI Sequence Detail	5819	C57BL/6J
transcript	OTTMUST00000081205	VEGA | MGI Sequence Detail	2671	Not Applicable
polypeptide	OTTMUSP00000043393	VEGA | MGI Sequence Detail	462	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
InterPro	IPR002418	Transcription regulator Myc
InterPro	IPR012682	Transcription regulator Myc, N-terminal
Protein Ontology	PR:000010812	N-myc proto-oncogene protein

References

(Earliest) J:7964 Yancopoulos GD, et al., N-myc can cooperate with ras to transform normal cells in culture. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5455-9
(Latest) J:191198 Kopecky BJ, et al., Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability. Dev Dyn. 2013 Feb;242(2):132-47
All references(188)

Other accession IDs

MGD-MRK-12903, MGD-MRK-12905