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Mycn
Gene Detail
Symbol

Name
ID
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
MGI:97357
Synonyms
bHLHe37, Nmyc, N-myc, Nmyc1, Nmyc-1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
6.14 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr12:12936096-12941914 bp, - strand
From VEGA annotation of GRCm38

  5819 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3922  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYCN
Protein SuperFamily: myc protein
Gene Tree: Mycn

Human
homologs
MYCN, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4613
neXtProt AC: NX_P04198

Human Synonyms: bHLHe37, MODED, N-myc, NMYC, ODED

Human Chr (Location): 2p24.3; chr2:15940438-15947007 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human MYCN

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(6) Targeted(14) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired development of the mesonephric tubules, neuroepithelium, sensory ganglia, heart, lung, stomach, and liver. Mutants die around embryonic day 11.5.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Mycn interacts with 259 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process branching morphogenesis of an epithelial tube, cartilage condensation, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (118 records)
Data Summary: Results (541)    Tissues (236)    Images (86)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 431
Northern blot 80
Western blot 2
RT-PCR 16
RNase protection 2
cDNA source data(52)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA MYCN ; Xenbase mycn ; ZFIN mycn    NEW 
Molecular
reagents
All nucleic(76) Genomic(7) cDNA(56) Primer pair(6) Other(7)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000032640 (Evidence)
Ensembl Gene Model ENSMUSG00000037169 (Evidence)
Entrez Gene 18109 (Evidence)
UniGene 16469
DFCI TC1578870, TC1590776
DoTS DT.101386491, DT.526113
NIA Mouse Gene Index U033813
Consensus CDS Project CCDS25818.1
International Mouse Phenotyping Consortium Status Mycn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032640 VEGA Gene Model | MGI Sequence Detail 5819 C57BL/6J ±  kb
transcript OTTMUST00000081206 VEGA | MGI Sequence Detail 2522 Not Applicable 
polypeptide OTTMUSP00000043394 VEGA | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(4)
Polymorphisms
All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR002418 Transcription regulator Myc
InterPro IPR012682 Transcription regulator Myc, N-terminal
Protein Ontology PR:000010812 N-myc proto-oncogene protein
References
(Earliest) J:7964 Yancopoulos GD, et al., N-myc can cooperate with ras to transform normal cells in culture. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5455-9
(Latest) J:220960 Akiyama R, et al., Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80
All references(205)
Other
accession IDs
MGD-MRK-12903, MGD-MRK-12905

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory