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Mycn Gene Detail
Summary
  • Symbol
    Mycn
  • Name
    v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
  • Synonyms
    bHLHe37, Nmyc, N-myc, Nmyc1, Nmyc-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97357
    NCBI Gene: 18109
  • Gene Overview
    MyGene.info: MYCN
Location & Maps
more
  • Sequence Map
    Chr12:12936096-12941914 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5819 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MYCN, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYCN, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHe37, MODED, N-myc, NMYC, ODED
  • Links
    NCBI Gene ID: 4613
    neXtProt AC: NX_P04198

  • Chr Location
    2p24.3; chr2:15940438-15947007 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human MYCN associations

Human Disease Mouse Models
       Feingold Syndrome 1; FGLDS1   OMIM: 164280
Tracheoesophageal Fistula with or without Esophageal Atresia   OMIM: 189960
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    106 phenotypes from 11 alleles in 9 genetic backgrounds
    14 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Gene trapped
    6
  • Targeted
    14
  • Transgenic
    3
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit impaired development of the mesonephric tubules, neuroepithelium, sensory ganglia, heart, lung, stomach, and liver. Mutants die around embryonic day 11.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032640 VEGA Gene Model | MGI Sequence Detail 5819 C57BL/6J ±  kb
transcript OTTMUST00000081205 VEGA | MGI Sequence Detail 2671 Not Applicable  
polypeptide OTTMUSP00000043393 VEGA | MGI Sequence Detail 462 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    65 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010812 N-myc proto-oncogene protein
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR002418 Transcription regulator Myc
    IPR012682 Transcription regulator Myc, N-terminal
Molecular
Reagents
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  • All nucleic 77
    Genomic 7
    cDNA 57
    Primer pair 6
    Other 7

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-12903, MGD-MRK-12905
References
more
  • Summaries
    All 206
    Developmental Gene Expression 122
    Diseases 12
    Gene Ontology 11
    Phenotypes 75
  • Earliest
    J:7964 Yancopoulos GD, et al., N-myc can cooperate with ras to transform normal cells in culture. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5455-9
  • Latest
    J:224948 Lin C, et al., A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 2015 Jul 1;403(1):101-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory