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Nme2
Gene Detail
Symbol

Name
ID
Nme2
NME/NM23 nucleoside diphosphate kinase 2
MGI:97356
Synonyms
NM23-H2, nm23-M2, non-metastatic cells 2, protein (NM23B) expressed in
Feature Type
protein coding gene
Genetic Map
Chromosome 11
58.88 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:93949814-93956259 bp, - strand
From VEGA annotation of GRCm38

  6446 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NME2
Protein SuperFamily: nucleoside diphosphate kinase
Gene Tree: Nme2

Human
homologs
NME2, NME/NM23 nucleoside diphosphate kinase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4831
neXtProt AC: NX_P22392

Human Synonyms: NDKB, NDPKB, NDPK-B, NM23B, NM23-H2, PUF

Human Chr (Location): 17q21.3; chr17:51165435-51171744 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Genomic Mutations involving Nme2 (4)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trapped allele exhibit impaired Th1 and Th2 cell KCa3.1 channel activity and TCR-stimulated calcium ion flux and cytokine production.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Nme2 interacts with 14 markers (Mir30b, Mir194-2, Mir199a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process activation of mitophagy in response to mitochondrial depolarization, CTP biosynthetic process, ...
Component cell periphery, cell projection, ...
Function ATP binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (158)    Tissues (148)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 146
Northern blot 12
cDNA source data(295)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nme2 ; ZFIN nme2a, nme2b.1, nme2b.2    NEW 
Molecular
reagents
All nucleic(297) cDNA(295) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000001491 (Evidence)
Ensembl Gene Model ENSMUSG00000020857 (Evidence)
Entrez Gene 18103 (Evidence)
UniGene 1260
DFCI TC1573271, TC1593977
DoTS DT.110514052, DT.537221, DT.94362193, DT.97363473, DT.97383636
NIA Mouse Gene Index U033270, U050039, U056821, U109561
EC 2.7.13.3, 2.7.4.6
Consensus CDS Project CCDS25246.1
International Mouse Phenotyping Consortium Status Nme2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001491 VEGA Gene Model | MGI Sequence Detail 6446 C57BL/6J ±  kb
transcript OTTMUST00000002954 VEGA | MGI Sequence Detail 1012 Not Applicable 
polypeptide OTTMUSP00000001443 VEGA | MGI Sequence Detail 152 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001564 Nucleoside diphosphate kinase
InterPro IPR023005 Nucleoside diphosphate kinase, active site
Protein Ontology PR:000011282 nucleoside diphosphate kinase B
References
(Earliest) J:2262 Urano T, et al., Molecular cloning and functional expression of the second mouse nm23/NDP kinase gene, nm23-M2. FEBS Lett. 1992 Sep 14;309(3):358-62
(Latest) J:220406 Ishihara K, et al., Comparative proteomic profiling reveals aberrant cell proliferation in the brain of embryonic Ts1Cje, a mouse model of Down syndrome. Neuroscience. 2014 Sep 28;281C:1-15
All references(60)
Other
accession IDs
MGD-MRK-12902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory