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Nme2 Gene Detail
Summary
  • Symbol
    Nme2
  • Name
    NME/NM23 nucleoside diphosphate kinase 2
  • Synonyms
    NM23-H2, nm23-M2, non-metastatic cells 2, protein (NM23B) expressed in
  • Feature Type
    protein coding gene
  • IDs
    MGI:97356
    NCBI Gene: 18103
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:93840640-93847082 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 58.88 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97356
 protein coding gene Chr11:93840640-93847085 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018946
 protein coding gene Chr11:95977925-95984786 (-)
A/J MGP_AJ_G0018914
 protein coding gene Chr11:92180365-92186718 (-)
AKR/J MGP_AKRJ_G0018884
 protein coding gene Chr11:95053512-95059843 (-)
BALB/cJ MGP_BALBcJ_G0018887
 protein coding gene Chr11:92606690-92612986 (-)
C3H/HeJ MGP_C3HHeJ_G0018701
 protein coding gene Chr11:95125393-95131791 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019339
 protein coding gene Chr11:98975489-98981870 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016970
 protein coding gene Chr11:89670827-89677369 (-)
CAST/EiJ MGP_CASTEiJ_G0018256
 protein coding gene Chr11:95812084-95818588 (-)
CBA/J MGP_CBAJ_G0018672
 protein coding gene Chr11:103084656-103091045 (-)
DBA/2J MGP_DBA2J_G0018780
 protein coding gene Chr11:91743612-91750070 (-)
FVB/NJ MGP_FVBNJ_G0018769
 protein coding gene Chr11:91162014-91168451 (-)
LP/J MGP_LPJ_G0018850
 protein coding gene Chr11:96536799-96544416 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018796
 protein coding gene Chr11:103137933-103145093 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019379
 protein coding gene Chr11:95237074-95245571 (-)
PWK/PhJ MGP_PWKPhJ_G0018026
 protein coding gene Chr11:92663462-92670291 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017816
 protein coding gene Chr11:94927315-94933983 (-)
WSB/EiJ MGP_WSBEiJ_G0018305
 protein coding gene Chr11:95122062-95128883 (-)



Homology
more
  • Human Ortholog
    NME1-NME2, NME1-NME2 readthrough
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NME1-NME2, NME1-NME2 readthrough
  • Synonyms
    NM23-LV, NMELV
  • Links
    NCBI Gene ID: 654364
    neXtProt AC: NX_P22392

  • Chr Location
    17q21.33; chr17:51153559-51171744 (+)  GRCh38
  • Human Ortholog
    NME2, NME/NM23 nucleoside diphosphate kinase 2
  • Synonyms
    NDKB, NDPKB, NDPK-B, NM23B, NM23-H2, PUF
  • Links
    NCBI Gene ID: 4831
    neXtProt AC: NX_P22392
    UniProt: P22392

  • Chr Location
    17q21.33; chr17:51165435-51171744 (+)  GRCh38
  • Human Ortholog
    NME2P1, NME2 pseudogene 1
  • Links
    NCBI Gene ID: 283458
    UniProt: O60361

  • Chr Location
    12q24.23; chr12:120282218-120282856 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NME2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit impaired Th1 and Th2 cell KCa3.1 channel activity and TCR-stimulated calcium ion flux and cytokine production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    167
  • cDNA Data
    297
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18103 NCBI Gene Model | MGI Sequence Detail 6443 C57BL/6J ±  kb
    transcript NM_008705 RefSeq | MGI Sequence Detail 1027 C57BL/6  
    polypeptide Q01768 UniProt | EBI | MGI Sequence Detail 152 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 304
      cDNA 297
      Primer pair 2
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12902
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 14
      Phenotypes 27
    • Earliest
      J:2262 Urano T, et al., Molecular cloning and functional expression of the second mouse nm23/NDP kinase gene, nm23-M2. FEBS Lett. 1992 Sep 14;309(3):358-62
    • Latest
      J:340281 Iuso D, et al., Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet. Sci Adv. 2023 Sep 8;9(36):eadh0140
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory