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Nme2 Gene Detail
Summary
  • Symbol
    Nme2
  • Name
    NME/NM23 nucleoside diphosphate kinase 2
  • Synonyms
    NM23-H2, nm23-M2, non-metastatic cells 2, protein (NM23B) expressed in
  • Feature Type
    protein coding gene
  • IDs
    MGI:97356
    NCBI Gene: 18103
  • Gene Overview
    MyGene.info: NME2
Location & Maps
more
  • Sequence Map
    Chr11:93949814-93956259 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6446 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 58.88 cM, cytoband C
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NME2, NME/NM23 nucleoside diphosphate kinase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NME2, NME/NM23 nucleoside diphosphate kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NDKB, NDPKB, NDPK-B, NM23B, NM23-H2, PUF
  • Links
    NCBI Gene ID: 4831
    neXtProt AC: NX_P22392

  • Chr Location
    17q21.3; chr17:51165435-51171744 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    2
  • Targeted
    8
  • Genomic Mutations
    4 involving Nme2
  • Incidental Mutations
    APF
Mice homozygous for a gene trapped allele exhibit impaired Th1 and Th2 cell KCa3.1 channel activity and TCR-stimulated calcium ion flux and cytokine production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001491 VEGA Gene Model | MGI Sequence Detail 6446 C57BL/6J ±  kb
transcript OTTMUST00000002954 VEGA | MGI Sequence Detail 1012 Not Applicable  
polypeptide OTTMUSP00000001443 VEGA | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    115 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 297
    cDNA 295
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12902
References
more
  • Summaries
    All 56
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 9
    Phenotypes 18
  • Earliest
    J:2262 Urano T, et al., Molecular cloning and functional expression of the second mouse nm23/NDP kinase gene, nm23-M2. FEBS Lett. 1992 Sep 14;309(3):358-62
  • Latest
    J:227167 Feng Y, et al., Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2292-300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory