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Nme1
Gene Detail
Symbol

Name
ID
Nme1
NME/NM23 nucleoside diphosphate kinase 1
MGI:97355
Synonyms
NDPK-A, NM23-M1, non-metastatic cells 1, protein (NM23A) expressed in
Feature Type
protein coding gene
Genetic Map
Chromosome 11
58.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:93956979-93968521 bp, - strand
From VEGA annotation of GRCm38

  11543 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: NME1
Protein SuperFamily: nucleoside diphosphate kinase
Gene Tree: Nme1

Human
homologs
NME1, NME/NM23 nucleoside diphosphate kinase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4830
neXtProt AC: NX_P15531

Human Synonyms: AWD, GAAD, NB, NBS, NDKA, NDPKA, NDPK-A, NM23, NM23-H1

Human Chr (Location): 17q21.3; chr17:51153559-51162089 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NME1

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Genomic Mutations involving Nme1 (4)
Incidental mutations (data from APF )
 
Homozygous mice for a targeted mutation of this gene are born normally, but exhibited high perinatal mortality of all genotypes on congenic backgrounds. This appears to be a maternal effect because the presence of a single functioning allele in females can prevent this mortality.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Nme1 interacts with 281 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process cell differentiation, CTP biosynthetic process, ...
Component centrosome, cytoplasm, ...
Function ATP binding, deoxyribonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (264)    Tissues (174)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 157
In situ reporter (knock in) 29
Northern blot 78
cDNA source data(209)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(213) cDNA(211) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000001490 (Evidence)
Ensembl Gene Model ENSMUSG00000037601 (Evidence)
Entrez Gene 18102 (Evidence)
UniGene 439702
DFCI TC1573415, TC1677355
DoTS DT.101308806, DT.101360516, DT.40177728, DT.94201084
NIA Mouse Gene Index U033271
EC 2.7.4.6
Consensus CDS Project CCDS25247.1
International Mouse Phenotyping Consortium Status Nme1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001490 VEGA Gene Model | MGI Sequence Detail 11543 C57BL/6J ±  kb
transcript OTTMUST00000002951 VEGA | MGI Sequence Detail 3181 Not Applicable 
polypeptide OTTMUSP00000001440 VEGA | MGI Sequence Detail 152 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001564 Nucleoside diphosphate kinase
InterPro IPR023005 Nucleoside diphosphate kinase, active site
Protein Ontology PR:000011281 nucleoside diphosphate kinase A
References
(Earliest) J:15840 Steeg PS, et al., Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst. 1988 Apr 6;80(3):200-4
(Latest) J:212078 Boissan M, et al., Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling. Science. 2014 Jun 27;344(6191):1510-5
All references(54)
Other
accession IDs
MGD-MRK-12901, MGI:2144352

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory