Nme1
Gene Detail

Symbol Name ID

Nme1 NME/NM23 nucleoside diphosphate kinase 1 MGI:97355

Synonyms

NDPK-A, NM23-M1, non-metastatic cells 1, protein (NM23A) expressed in

Feature Type

protein coding gene

Genetic Map

Chromosome 11

58.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:93956979-93968521 bp, - strand From VEGA annotation of GRCm38   11543 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128514  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nucleoside diphosphate kinase
Gene Tree: Nme1

Human homologs

Human Homolog		NME1, NME/NM23 nucleoside diphosphate kinase 1
NCBI Gene ID		4830
neXtProt AC		NX_P15531
Human Synonyms		AWD, GAAD, NB, NBS, NDKA, NDPKA, NDPK-A, NM23, NM23-H1
Human Chr (Location)		17q21.3; chr17:49230920-49239450 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NME1

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous mice for a targeted mutation of this gene are born normally, but exhibited high perinatal mortality of all genotypes on congenic backgrounds. This appears to be a maternal effect because the presence of a single functioning allele in females can prevent this mortality.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	cell differentiation, CTP biosynthetic process, ...
Component	centrosome, cytoplasm, ...
Function	ATP binding, deoxyribonuclease activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (229)    Tissues (154)    Images (15)
Theiler Stages: 10, 17, 18, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	157
Northern blot	72

cDNA source data(207)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(211) cDNA(209) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000001490 (Evidence)
Ensembl Gene Model	ENSMUSG00000037601 (Evidence)
Entrez Gene	18102 (Evidence)
UniGene	439702
DFCI	TC1573415, TC1677355
DoTS	DT.101308806, DT.101360516, DT.40177728, DT.94201084
NIA Mouse Gene Index	U033271
EC	2.7.4.6
Consensus CDS Project	CCDS25247.1
International Mouse Knockout Project Status	Nme1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001490	VEGA Gene Model | MGI Sequence Detail	11543	C57BL/6J
transcript	OTTMUST00000002951	VEGA | MGI Sequence Detail	3181	Not Applicable
polypeptide	OTTMUSP00000001440	VEGA | MGI Sequence Detail	152	Not Applicable

All sequences(41) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(69 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001564	Nucleoside diphosphate kinase
InterPro	IPR023005	Nucleoside diphosphate kinase, active site
Protein Ontology	PR:000011281	nucleoside diphosphate kinase A

References

(Earliest) J:15840 Steeg PS, et al., Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst. 1988 Apr 6;80(3):200-4
(Latest) J:181035 Jarrett SG, et al., Metastasis suppressor NM23-H1 promotes repair of UV-induced DNA damage and suppresses UV-induced melanomagenesis. Cancer Res. 2012 Jan 1;72(1):133-43
All references(55)

Other accession IDs

MGD-MRK-12901, MGI:2144352