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Nme1 Gene Detail
Summary
  • Symbol
    Nme1
  • Name
    NME/NM23 nucleoside diphosphate kinase 1
  • Synonyms
    NDPK-A, NM23-M1, non-metastatic cells 1, protein (NM23A) expressed in
  • Feature Type
    protein coding gene
  • IDs
    MGI:97355
    NCBI Gene: 18102
Location & Maps
more
  • Sequence Map
    Chr11:93956979-93968521 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11543 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NME1, NME/NM23 nucleoside diphosphate kinase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NME1, NME/NM23 nucleoside diphosphate kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AWD, GAAD, NB, NBS, NDKA, NDPKA, NDPK-A, NM23, NM23-H1
  • Links
    NCBI Gene ID: 4830
    neXtProt AC: NX_P15531

  • Chr Location
    17q21.3; chr17:51153559-51162089 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NME1 associations

Human Disease Mouse Models
       Neuroblastoma, Susceptibility to   OMIM: 256700
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    1
  • Targeted
    8
  • Genomic Mutations
    4 involving Nme1
  • Incidental Mutations
    APF
Homozygous mice for a targeted mutation of this gene are born normally, but exhibited high perinatal mortality of all genotypes on congenic backgrounds. This appears to be a maternal effect because the presence of a single functioning allele in females can prevent this mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001490 VEGA Gene Model | MGI Sequence Detail 11543 C57BL/6J ±  kb
transcript OTTMUST00000002951 VEGA | MGI Sequence Detail 3181 Not Applicable  
polypeptide OTTMUSP00000001440 VEGA | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    217 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011281 nucleoside diphosphate kinase A
  • EC
  • InterPro Domains
    IPR001564 Nucleoside diphosphate kinase
    IPR023005 Nucleoside diphosphate kinase, active site
Molecular
Reagents
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  • All nucleic 213
    cDNA 211
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12901, MGI:2144352
References
more
  • Summaries
    All 51
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:15840 Steeg PS, et al., Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst. 1988 Apr 6;80(3):200-4
  • Latest
    J:212078 Boissan M, et al., Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling. Science. 2014 Jun 27;344(6191):1510-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory