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Nid1 Gene Detail
Summary
  • Symbol
    Nid1
  • Name
    nidogen 1
  • Synonyms
    entactin, entactin 1, entactin-1, nidogen-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97342
    NCBI Gene: 18073
  • Gene Overview
    MyGene.info: NID1
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr13:13437602-13512275 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 5.26 cM
  • Mapping Data
    30 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    322 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97342
protein coding gene Chr13:13437551-13512275 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020233
protein coding gene Chr13:9525873-10457040 (+)
A/J MGP_AJ_G0020192
protein coding gene Chr13:10321973-10392506 (+)
AKR/J MGP_AKRJ_G0020166
protein coding gene Chr13:10431103-10519277 (+)
BALB/cJ MGP_BALBcJ_G0020179
protein coding gene Chr13:10349629-10398182 (+)
C3H/HeJ MGP_C3HHeJ_G0019979
protein coding gene Chr13:9657989-10669650 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020622
protein coding gene Chr13:10923239-11017520 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018228
protein coding gene Chr13:9117827-9189831 (+)
CAST/EiJ MGP_CASTEiJ_G0019516
protein coding gene Chr13:10230659-10309957 (+)
CBA/J MGP_CBAJ_G0019946
protein coding gene Chr13:11276577-11369265 (+)
DBA/2J MGP_DBA2J_G0020065
protein coding gene Chr13:9988740-10064572 (+)
FVB/NJ MGP_FVBNJ_G0020047
protein coding gene Chr13:9742401-9791307 (+)
LP/J MGP_LPJ_G0020136
protein coding gene Chr13:10585347-10643111 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020082
protein coding gene Chr13:10477742-11461603 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020649
protein coding gene Chr13:10179952-10307815 (+)
PWK/PhJ MGP_PWKPhJ_G0019279
protein coding gene Chr13:10072395-10155944 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019086
protein coding gene Chr13:9386420-9534022 (+)
WSB/EiJ MGP_WSBEiJ_G0019577
protein coding gene Chr13:10254628-10340937 (+)



Homology
more
  • Human Ortholog
    NID1, nidogen 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NID1, nidogen 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NID
  • Links
    NCBI Gene ID: 4811
    neXtProt AC: NX_P14543
    UniProt: P14543

  • Chr Location
    1q42.3; chr1:235975830-236065181 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1878
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NID1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neurologic deficits including seizure-like symptoms and loss of muscle control in the hind legs, and show altered basement membrane morphology in selected locations including brain capillaries and the lens capsule.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18073 NCBI Gene Model | MGI Sequence Detail 74674 C57BL/6J ±  kb
    transcript NM_010917 RefSeq | MGI Sequence Detail 6046 C57BL/6  
    polypeptide P10493 UniProt | EBI | MGI Sequence Detail 1245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 230
      Genomic 28
      cDNA 195
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12878
    References
    more
    • Summaries
      All 172
      Developmental Gene Expression 99
      Gene Ontology 25
      Phenotypes 15
    • Earliest
      J:34858 Durkin ME, et al., Amino acid sequence and domain structure of entactin. Homology with epidermal growth factor precursor and low density lipoprotein receptor. J Cell Biol. 1988 Dec;107(6 Pt 2):2749-56
    • Latest
      J:267504 Kiyama T, et al., Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Mol Neurodegener. 2018 Oct 17;13(1):56

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory