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Nid1
Gene Detail
Symbol

Name
ID
Nid1
nidogen 1
MGI:97342
STS
Synonyms
entactin, entactin 1, entactin-1, nidogen-1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
5.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr13:13437602-13512275 bp, + strand
From NCBI annotation of GRCm38

  74674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1878  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NID1
Protein SuperFamily: nidogen-1
Gene Tree: Nid1

Human
homologs
NID1, nidogen 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4811
neXtProt AC: NX_P14543

Human Synonyms: NID

Human Chr (Location): 1q43; chr1:235975830-236065181 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(13) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit neurologic deficits including seizure-like symptoms and loss of muscle control in the hind legs, and show altered basement membrane morphology in selected locations including brain capillaries and the lens capsule.
 
Interactions
Nid1 interacts with 316 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell adhesion, cell-matrix adhesion, ...
Component basal lamina, basement membrane, ...
Function calcium ion binding, collagen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (90 records)
Data Summary: Results (295)    Tissues (115)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
RNA in situ 199
Northern blot 17
RT-PCR 50
cDNA source data(192)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA NID1 ; Xenbase nid1 ; ZFIN nid1b    NEW 
Molecular
reagents
All nucleic(228) Genomic(28) cDNA(193) Primer pair(6) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000005397 (Evidence)
Entrez Gene 18073 (Evidence)
UniGene 4691
DFCI TC1572194
DoTS DT.94280402
NIA Mouse Gene Index U014556
PDB 1H4U, 1NPE, 1GL4
Consensus CDS Project CCDS26244.1
International Mouse Phenotyping Consortium Status Nid1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18073 NCBI Gene Model | MGI Sequence Detail 74674 C57BL/6J ±  kb
transcript NM_010917 RefSeq | MGI Sequence Detail 6046 C57BL/6 
polypeptide P10493 UniProt | EBI | MGI Sequence Detail 1245 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(11) : SNPs within 2kb(357 from dbSNP Build 137)    SNPs within 2kb including multiple locations(423)
Protein-related
information
ResourceIDDescription
InterPro IPR026823 Complement Clr-like EGF domain
InterPro IPR024731 EGF domain, merozoite surface protein 1-like
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR006605 G2 nidogen/fibulin G2F
InterPro IPR009017 Green fluorescent protein
InterPro IPR023413 Green fluorescent protein-like
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR003886 Nidogen, extracellular domain
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000011208 nidogen-1
Graphical View of Protein Domain Structure
References
(Earliest) J:34858 Durkin ME, et al., Amino acid sequence and domain structure of entactin. Homology with epidermal growth factor precursor and low density lipoprotein receptor. J Cell Biol. 1988 Dec;107(6 Pt 2):2749-56
(Latest) J:215166 Ayala de la Pena F, et al., Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects. PLoS One. 2014;9(4):e95888
All references(155)
Other
accession IDs
MGD-MRK-12878

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory