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Nid1 Gene Detail
Summary
  • Symbol
    Nid1
  • Name
    nidogen 1
  • Synonyms
    entactin, entactin 1, entactin-1, nidogen-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97342
    NCBI Gene: 18073
  • Gene Overview
    MyGene.info: NID1
Location & Maps
more
  • Sequence Map
    Chr13:13437602-13512275 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74674 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 5.26 cM
  • Mapping Data
    30 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    NID1, nidogen 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NID1, nidogen 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NID
  • Links
    NCBI Gene ID: 4811
    neXtProt AC: NX_P14543

  • Chr Location
    1q43; chr1:235975830-236065181 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1878
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NID1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neurologic deficits including seizure-like symptoms and loss of muscle control in the hind legs, and show altered basement membrane morphology in selected locations including brain capillaries and the lens capsule.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18073 NCBI Gene Model | MGI Sequence Detail 74674 C57BL/6J ±  kb
transcript NM_010917 RefSeq | MGI Sequence Detail 6046 C57BL/6  
polypeptide P10493 UniProt | EBI | MGI Sequence Detail 1245 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    322 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 229
    Genomic 28
    cDNA 194
    Primer pair 6
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12878
References
more
  • Summaries
    All 152
    Developmental Gene Expression 90
    Gene Ontology 21
    Phenotypes 14
  • Earliest
    J:34858 Durkin ME, et al., Amino acid sequence and domain structure of entactin. Homology with epidermal growth factor precursor and low density lipoprotein receptor. J Cell Biol. 1988 Dec;107(6 Pt 2):2749-56
  • Latest
    J:215166 Ayala de la Pena F, et al., Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects. PLoS One. 2014;9(4):e95888

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory