About   Help   FAQ
Nhlh2
Gene Detail
 Symbol
Name
ID
Nhlh2
nescient helix loop helix 2
MGI:97324
Synonyms 6230401I09Rik, bHLHa34, Hen2, Nscl-2, NSCL2
Feature Type protein coding gene
Genetic Map
Chromosome 3
44.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:102010145-102015492 bp, + strand
From NCBI annotation of GRCm38

  5348 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nhlh2

Human
homologs
Human Homolog NHLH2, nescient helix loop helix 2
NCBI Gene ID 4808
neXtProt AC  NX_Q02577
Human Synonyms  bHLHa34, HEN2, NSCL2
Human Chr (Location)  1p12-p11; chr1:115836377-115841126 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Loss of function results in adult-onset obesity and reproductive defects, including hypogonadism, due to disruption of the hypothalamic-pituitary axis. Mutant male mice are sterile, whereas female mice show variable fertility dependent on the presence or absence of male mice.
 
Interactions
Nhlh2 interacts with 329 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell differentiation, mating behavior, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (222)    Tissues (125)    Images (49)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 222
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(2) cDNA(23) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000048540 (Evidence)
Entrez Gene18072 (Evidence)
UniGene137286
DFCITC1581984, TC1590224
DoTSDT.87072142, DT.97374740, DT.99850961
NIA Mouse Gene IndexU003644
Consensus CDS ProjectCCDS17685.1
International Mouse Knockout Project StatusNhlh2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18072 NCBI Gene Model | MGI Sequence Detail 5348 C57BL/6J ±  kb
transcript NM_178777 RefSeq | MGI Sequence Detail 3353 C57BL/6 
polypeptide Q64221 UniProt | EBI | MGI Sequence Detail 135 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000011201 helix-loop-helix protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:2496 Brown L, et al., HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8492-6
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(71)
Other
accession IDs
MGD-MRK-12843, MGI:2443536

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory