Klk1b3
Gene Detail

Symbol Name ID

Klk1b3 kallikrein 1-related peptidase b3 MGI:97322

STS

D7Nds5

Synonyms

mGk-3, Ngfg

Feature Type

protein coding gene

Genetic Map

Chromosome 7

28.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)

Sequence Map

Chr7:44198191-44202351 bp, + strand From VEGA annotation of GRCm38   4161 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68141  Vertebrate Homology Class
1 human; 14 mouse; 1 rhesus macaque

Protein SuperFamily: trypsin
Gene Tree: Klk1b3

Human homologs

Human Homolog		KLK3, kallikrein-related peptidase 3
NCBI Gene ID		354
neXtProt AC		NX_P07288
Human Synonyms		APS, hK3, KLK2A1, PSA
Human Chr (Location)		19q13.41; chr19:51358171-51364020 (+)  GRCh37.p10

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	proteolysis, signal transduction
Function	catalytic activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (62)    Tissues (25)    Images (2)
Theiler Stages: 1, 2, 4, 11, 15, 18, 23, 28

Assay Type	Results
RNA in situ	24
RT-PCR	38

cDNA source data(11)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(9) cDNA(12) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000027267 (Evidence)
Ensembl Gene Model	ENSMUSG00000066515 (Evidence)
Entrez Gene	18050 (Evidence)
UniGene	439740
DFCI	TC1588577
NIA Mouse Gene Index	U008031
EC	3.4.21.35
PDB	1SGF
Consensus CDS Project	CCDS21199.1
International Mouse Knockout Project Status	Klk1b3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027267	VEGA Gene Model | MGI Sequence Detail	4161	C57BL/6J
transcript	OTTMUST00000067411	VEGA | MGI Sequence Detail	888	Not Applicable
polypeptide	OTTMUSP00000033916	VEGA | MGI Sequence Detail	261	Not Applicable

All sequences(19) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(7) : PCR(3) RFLP(4) SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000009611	kallikrein 1-related peptidase b3

References

(Earliest) J:32363 Thomas KA, et al., The amino acid sequence of the gamma-subunit of mouse submaxillary gland 7 S nerve growth factor. J Biol Chem. 1981 Sep 10;256(17):9156-66
(Latest) J:111453 Lundwall A, et al., A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Biol Chem. 2006 Jun;387(6):637-41
All references(58)

Other accession IDs

MGD-MRK-12841