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Klk1b3
Gene Detail
 Symbol
Name
ID
Klk1b3
kallikrein 1-related peptidase b3
MGI:97322
STS D7Nds5
Synonyms mGk-3, Ngfg
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr7:44198191-44202351 bp, + strand
From VEGA annotation of GRCm38

  4161 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68141  Vertebrate Homology Class
1 human; 14 mouse; 1 rhesus macaque

Protein SuperFamily: trypsin
Gene Tree: Klk1b3

Human
homologs
Human Homolog KLK3, kallikrein-related peptidase 3
NCBI Gene ID 354
neXtProt AC  NX_P07288
Human Synonyms  APS, hK3, KLK2A1, PSA
Human Chr (Location)  19q13.41; chr19:50854915-50860764 (+)  GRCh38
Interactions
Klk1b3 interacts with 14 markers (Mir92-1, Mir193b, Mir218-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process intracellular signal transduction, proteolysis
Component extracellular vesicular exosome, nucleus
Function catalytic activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (60)    Tissues (24)    Images (2)
Theiler Stages: 1, 2, 4, 11, 15, 18, 23, 28
Assay TypeResults
RNA in situ 24
RT-PCR 36
cDNA source data(11)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(9) cDNA(12) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027267 (Evidence)
Ensembl Gene ModelENSMUSG00000066515 (Evidence)
Entrez Gene18050 (Evidence)
UniGene439740
DFCITC1588577
NIA Mouse Gene IndexU008031
EC3.4.21.35
PDB1SGF
Consensus CDS ProjectCCDS21199.1
International Mouse Knockout Project StatusKlk1b3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027267 VEGA Gene Model | MGI Sequence Detail 4161 C57BL/6J ±  kb
transcript OTTMUST00000067411 VEGA | MGI Sequence Detail 888 Not Applicable 
polypeptide OTTMUSP00000033916 VEGA | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(7) : PCR(3) RFLP(4) SNPs within 2kb(82 from dbSNP Build 137)    SNPs within 2kb including multiple locations(84)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009611 kallikrein 1-related peptidase b3
References (Earliest) J:32363 Thomas KA, et al., The amino acid sequence of the gamma-subunit of mouse submaxillary gland 7 S nerve growth factor. J Biol Chem. 1981 Sep 10;256(17):9156-66
(Latest) J:111453 Lundwall A, et al., A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Biol Chem. 2006 Jun;387(6):637-41
All references(59)
Other
accession IDs
MGD-MRK-12841

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory