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Klk1b4 Gene Detail
Summary
  • Symbol
    Klk1b4
  • Name
    kallikrein 1-related pepidase b4
  • Synonyms
    mGk-4, Ngfa
  • Feature Type
    protein coding gene
  • IDs
    MGI:97320
    NCBI Gene: 18048
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44207435-44211754 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97320
protein coding gene Chr7:44207433-44211754 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032153
protein coding gene Chr7:44036649-44362526 (+)
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0032143
protein coding gene Chr7:43312972-43327429 (+)
C3H/HeJ MGP_C3HHeJ_G0031858
protein coding gene Chr7:45005420-45240272 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032629
protein coding gene Chr7:46320270-46599751 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031982
protein coding gene Chr7:43241639-43243001 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0032060
protein coding gene Chr7:45021328-45047225 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0032650
protein coding gene Chr7:43941476-43984013 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0031299
protein coding gene Chr7:44180416-44409253 (+)



Homology
more
  • Human Ortholog
    KLK3, kallikrein related peptidase 3
  • Vertebrate Orthologs
    16
  • Human Ortholog
    KLK3, kallikrein related peptidase 3
    Orthology source: HomoloGene
  • Synonyms
    APS, hK3, KLK2A1, PSA
  • Links
    NCBI Gene ID: 354
    neXtProt AC: NX_P07288
    UniProt: P07288

  • Chr Location
    19q13.33; chr19:50854915-50860764 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066513 Ensembl Gene Model | MGI Sequence Detail 4320 C57BL/6J ±  kb
transcript ENSMUST00000077354 Ensembl | MGI Sequence Detail 839 Not Applicable  
polypeptide ENSMUSP00000076576 Ensembl | MGI Sequence Detail 256 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 97
    Genomic 82
    cDNA 13
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12839
References
more
  • Summaries
    All 48
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:7072 Mason AJ, et al., Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides. Nature. 1983 May 26;303(5915):300-7
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory