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Klk1b4
Gene Detail
 Symbol
Name
ID
Klk1b4
kallikrein 1-related pepidase b4
MGI:97320
Synonyms mGk-4, Ngfa
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:44207435-44211754 bp, + strand
From VEGA annotation of GRCm38

  4320 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68141  Vertebrate Homology Class
1 human; 14 mouse; 1 rhesus macaque

Protein SuperFamily: trypsin
Gene Tree: Klk1b4

Human
homologs
Human Homolog KLK3, kallikrein-related peptidase 3
NCBI Gene ID 354
neXtProt AC  NX_P07288
Human Synonyms  APS, hK3, KLK2A1, PSA
Human Chr (Location)  19q13.41; chr19:50854915-50860764 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Klk1b4 interacts with 16 markers (Mir24-1, Mir24-2, Mir194-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process positive regulation of phosphatidylinositol 3-kinase activity, proteolysis, ...
Component extracellular vesicular exosome, intracellular, ...
Function catalytic activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (146)    Tissues (77)    Images (15)
Theiler Stages: 18, 19, 20, 21, 22, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 43
Northern blot 6
RT-PCR 97
cDNA source data(13)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(97) Genomic(82) cDNA(13) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027268 (Evidence)
Ensembl Gene ModelENSMUSG00000066513 (Evidence)
Entrez Gene18048 (Evidence)
UniGene440886
DFCITC1590361
NIA Mouse Gene IndexU288652
PDB1SGF
Consensus CDS ProjectCCDS21200.1
International Mouse Knockout Project StatusKlk1b4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027268 VEGA Gene Model | MGI Sequence Detail 4320 C57BL/6J ±  kb
transcript OTTMUST00000067412 VEGA | MGI Sequence Detail 839 Not Applicable 
polypeptide OTTMUSP00000033917 VEGA | MGI Sequence Detail 256 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(76 from dbSNP Build 137)    SNPs within 2kb including multiple locations(80)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009612 kallikrein 1-related peptidase-like b4
References (Earliest) J:7072 Mason AJ, et al., Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides. Nature. 1983 May 26;303(5915):300-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(48)
Other
accession IDs
MGD-MRK-12839

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory