Nfya MGI Mouse Gene Detail - MGI:97316 - nuclear transcription factor-Y alpha

Nfya Gene Detail

Symbol

Nfya
Name

nuclear transcription factor-Y alpha
Synonyms

Cbf-b, Sez10

Feature Type

protein coding gene
IDs

MGI:97316
NCBI Gene: 18044
Gene Overview

MyGene.info: NFYA
Alliance

gene page

Sequence Map

Chr17:48386885-48409906 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

23022 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 23.99 cM, cytoband C-D
Mapping Data

7 experiments

Human Ortholog

NFYA, nuclear transcription factor Y subunit alpha

Vertebrate Orthologs

11

Human Ortholog

NFYA, nuclear transcription factor Y subunit alpha
Orthology source: HGNC, HomoloGene
Synonyms

CBF-A, CBF-B, HAP2, NF-YA
Links

HGNC:7804

NCBI Gene ID: 4800

neXtProt AC: NX_P23511

UniProt: P23511
Chr Location

6p21.1; chr6:41072968-41102407 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 32114
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NFYA
Gene Tree

Nfya

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Phenotype Summary

4 phenotypes from 2 alleles in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

111
Gene trapped

107
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available

Inactivation of this locus impairs development and results in embryonic lethality.

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All GO Annotations

30
GO References

14

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

84
Tissues

81
cDNA Data

118
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NFYA

Xenbase nfya

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Nfya interacts with 333 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

88
RefSeq

16
UniProt

10
CCDS

CCDS28867.1, CCDS50142.1, CCDS84320.1, CCDS84321.1
UniGene

4929

			Length	Strain/Species	Flank
genomic	OTTMUSG00000035112	VEGA Gene Model \| MGI Sequence Detail	23022	C57BL/6J	± kb
transcript	OTTMUST00000089324	VEGA \| MGI Sequence Detail	3645	Not Applicable
polypeptide	OTTMUSP00000048807	VEGA \| MGI Sequence Detail	347	Not Applicable

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SNPs within 2kb

202 from dbSNP Build 142

RFLP

2

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UniProt

10 Sequences
Protein Ontology

PR:000011188 nuclear transcription factor Y subunit alpha

(term hierarchy)
InterPro Domains

IPR018362 CCAAT-binding factor, conserved site

IPR001289 Nuclear transcription factor Y subunit A

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All nucleic 126

Genomic 4

cDNA 118

Primer pair 2

Other 2

Microarray probesets 5

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MGD-MRK-12835, MGI:2146744

Summaries

All 81

Developmental Gene Expression 10

Gene Ontology 14

Phenotypes 15
Earliest

J:10763 van Huijsduijnen RH, et al., Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits. EMBO J. 1990 Oct;9(10):3119-27
Latest

J:263803 Zhang Y, et al., Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice. J Biol Chem. 2018 May 18;293(20):7894-7904

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/11/2018 MGI 6.12