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Nfya Gene Detail
Summary
  • Symbol
    Nfya
  • Name
    nuclear transcription factor-Y alpha
  • Synonyms
    Cbf-b, Sez10
  • Feature Type
    protein coding gene
  • IDs
    MGI:97316
    NCBI Gene: 18044
  • Gene Overview
    MyGene.info: NFYA
Location & Maps
more
  • Sequence Map
    Chr17:48386885-48409906 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      23022 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.99 cM, cytoband C-D
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    NFYA, nuclear transcription factor Y subunit alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NFYA, nuclear transcription factor Y subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CBF-A, CBF-B, HAP2, NF-YA
  • Links
    NCBI Gene ID: 4800
    neXtProt AC: NX_P23511

  • Chr Location
    6p21.3; chr6:41072968-41102407 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 32114
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NFYA
  • Gene Tree
    Nfya
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this locus impairs development and results in embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    64
  • Tissues
    64
  • cDNA Data
    116
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035112 VEGA Gene Model | MGI Sequence Detail 23022 C57BL/6J ±  kb
transcript OTTMUST00000089324 VEGA | MGI Sequence Detail 3645 Not Applicable  
polypeptide OTTMUSP00000048807 VEGA | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    202 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000011188 nuclear transcription factor Y subunit alpha
  • InterPro Domains
    IPR018362 CCAAT-binding factor, conserved site
    IPR001289 Nuclear transcription factor Y subunit A
Molecular
Reagents
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  • All nucleic 123
    Genomic 4
    cDNA 116
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12835, MGI:2146744
References
more
  • Summaries
    All 70
    Developmental Gene Expression 7
    Gene Ontology 14
    Phenotypes 13
  • Earliest
    J:10763 van Huijsduijnen RH, et al., Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits. EMBO J. 1990 Oct;9(10):3119-27
  • Latest
    J:210267 Yamanaka T, et al., NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization. Nat Commun. 2014;5:3354
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory