Nfya
Gene Detail

Symbol

Name
ID

Nfya
nuclear transcription factor-Y alpha
MGI:97316

Synonyms

Cbf-b, Sez10

Feature Type

protein coding gene

Genetic Map

Chromosome 17
23.99 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr17:48386885-48409906 bp, - strand From VEGA annotation of GRCm38   23022 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:32114  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Nfya

Human
homologs

Human Homolog		NFYA, nuclear transcription factor Y, alpha
NCBI Gene ID		4800
neXtProt AC		NX_P23511
Human Synonyms		CBF-A, CBF-B, HAP2, NF-YA
Human Chr (Location)		6p21.3; chr6:41072968-41102407 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(111) : Gene trapped(107) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Inactivation of this locus impairs development and results in embryonic lethality.

 

Interactions

Nfya interacts with 333 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (28 annotations)

Process	positive regulation of stem cell proliferation, positive regulation of transcription, DNA-templated, ...
Component	CCAAT-binding factor complex, nucleus, ...
Function	core promoter sequence-specific DNA binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (64)    Tissues (64)    Images (5)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	56
RT-PCR	8

cDNA source data(116)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(123) Genomic(4) cDNA(116) Primer pair(2) Other(1)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000035112 (Evidence)
Ensembl Gene Model	ENSMUSG00000023994 (Evidence)
Entrez Gene	18044 (Evidence)
UniGene	4929
DFCI	TC1575982, TC1597000, TC1603975
DoTS	DT.110580643, DT.491315, DT.94152315, DT.94184237
NIA Mouse Gene Index	U037898
Consensus CDS Project	CCDS28867.1, CCDS50142.1
International Mouse Knockout Project Status	Nfya

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035112	VEGA Gene Model | MGI Sequence Detail	23022	C57BL/6J
transcript	OTTMUST00000089324	VEGA | MGI Sequence Detail	3645	Not Applicable
polypeptide	OTTMUSP00000048807	VEGA | MGI Sequence Detail	347	Not Applicable

All sequences(103) RefSeq(16) UniProt(17)

Polymorphisms

RFLP(2) : SNPs within 2kb(204 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR018362	CCAAT-binding factor, conserved site
InterPro	IPR001289	CCAAT-binding transcription factor, subunit B
Protein Ontology	PR:000011188	nuclear transcription factor Y subunit alpha

References

(Earliest) J:10763 van Huijsduijnen RH, et al., Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits. EMBO J. 1990 Oct;9(10):3119-27
(Latest) J:210267 Yamanaka T, et al., NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization. Nat Commun. 2014;5:3354
All references(74)

Other
accession IDs

MGD-MRK-12835, MGI:2146744