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Nfya Gene Detail
Summary
  • Symbol
    Nfya
  • Name
    nuclear transcription factor-Y alpha
  • Synonyms
    Cbf-b, Sez10
  • Feature Type
    protein coding gene
  • IDs
    MGI:97316
    NCBI Gene: 18044
  • Gene Overview
    MyGene.info: NFYA
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:48386885-48409837 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.99 cM, cytoband C-D
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    202 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97316
 protein coding gene Chr17:48386885-48409906 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023871
 protein coding gene Chr17:49673895-49702260 (-)
A/J MGP_AJ_G0023831
 protein coding gene Chr17:48366627-48389317 (-)
AKR/J MGP_AKRJ_G0023799
 protein coding gene Chr17:48848655-48875506 (-)
BALB/cJ MGP_BALBcJ_G0023833
 protein coding gene Chr17:48289314-48311915 (-)
C3H/HeJ MGP_C3HHeJ_G0023596
 protein coding gene Chr17:49556242-49580080 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024276
 protein coding gene Chr17:51787040-51811281 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021725
 protein coding gene Chr17:45122411-45144833 (-)
CAST/EiJ MGP_CASTEiJ_G0023078
 protein coding gene Chr17:49741177-49764601 (-)
CBA/J MGP_CBAJ_G0023572
 protein coding gene Chr17:53642500-53672908 (-)
DBA/2J MGP_DBA2J_G0023701
 protein coding gene Chr17:47130612-47155644 (-)
FVB/NJ MGP_FVBNJ_G0023667
 protein coding gene Chr17:46796528-46819149 (-)
LP/J MGP_LPJ_G0023781
 protein coding gene Chr17:50378106-50406486 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023695
 protein coding gene Chr17:53128306-53152059 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024322
 protein coding gene Chr17:49182411-49206488 (-)
PWK/PhJ MGP_PWKPhJ_G0022823
 protein coding gene Chr17:46568951-46591574 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022637
 protein coding gene Chr17:46087933-46110356 (-)
WSB/EiJ MGP_WSBEiJ_G0023142
 protein coding gene Chr17:49780221-49804027 (-)



Homology
more
  • Human Ortholog
    NFYA, nuclear transcription factor Y subunit alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NFYA, nuclear transcription factor Y subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CBF-A, CBF-B, HAP2, NF-YA
  • Links
    NCBI Gene ID: 4800
    neXtProt AC: NX_P23511
    UniProt: P23511

  • Chr Location
    6p21.1; chr6:41072968-41102407 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 32114
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NFYA
  • Gene Tree
    Nfya
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Inactivation of this locus impairs development and results in embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    82
  • cDNA Data
    118
  • Literature Summary
    10
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18044 NCBI Gene Model | MGI Sequence Detail 22953 C57BL/6J ±  kb
transcript NM_001110832 RefSeq | MGI Sequence Detail 3728 C57BL/6  
polypeptide P23708 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 127
    Genomic 4
    cDNA 118
    Primer pair 3
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12835, MGI:2146744
References
more
  • Summaries
    All 82
    Developmental Gene Expression 10
    Gene Ontology 15
    Phenotypes 16
  • Earliest
    J:10763 van Huijsduijnen RH, et al., Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits. EMBO J. 1990 Oct;9(10):3119-27
  • Latest
    J:263803 Zhang Y, et al., Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice. J Biol Chem. 2018 May 18;293(20):7894-7904
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/12/2020
MGI 6.15 		The Jackson Laboratory