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Nefm Gene Detail
Summary
  • Symbol
    Nefm
  • Name
    neurofilament, medium polypeptide
  • Synonyms
    Nef3, neurofilament-M, NF160, NF165, Nfm, NF-M
  • Feature Type
    protein coding gene
  • IDs
    MGI:97314
    NCBI Gene: 18040
  • Gene Overview
    MyGene.info: NEFM
Location & Maps
more
  • Sequence Map
    Chr14:68082590-68124846 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42257 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 35.46 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    NEFM, neurofilament, medium polypeptide
  • Vertebrate Orthologs
    2
  • Human Ortholog
    NEFM, neurofilament, medium polypeptide
    Orthology source: HGNC
  • Synonyms
    NEF3, NFM, NF-M
  • Links
    NCBI Gene ID: 4741
    neXtProt AC: NX_P07197

  • Chr Location
    8p21; chr8:24913761-24919093 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotypes from multigenic genotypes
    4 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Nefm
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced axon diameter.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016378 VEGA Gene Model | MGI Sequence Detail 42257 C57BL/6J ±  kb
transcript OTTMUST00000039418 VEGA | MGI Sequence Detail 3334 Not Applicable  
polypeptide OTTMUSP00000017611 VEGA | MGI Sequence Detail 848 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    375 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR006821 Intermediate filament head, DNA-binding domain
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR002957 Keratin, type I
    IPR027697 Neurofilament medium polypeptide
Molecular
Reagents
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  • All nucleic 27
    Genomic 4
    cDNA 17
    Primer pair 4
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12832
References
more
  • Summaries
    All 702
    Developmental Gene Expression 634
    Gene Ontology 18
    Phenotypes 19
  • Earliest
    J:11960 Julien JP, et al., Cloning and developmental expression of the murine neurofilament gene family. Brain Res Mol Brain Res. 1986 Dec;387(3):243-50
  • Latest
    J:231817 Matsumoto S, et al., Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development. J Neurosci. 2016 Apr 27;36(17):4744-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory