Nefm
Gene Detail

Symbol Name ID

Nefm neurofilament, medium polypeptide MGI:97314

Synonyms

Nef3, neurofilament-M, NF160, NF165, Nfm, NF-M

Feature Type

protein coding gene

Genetic Map

Chromosome 14

35.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr14:68082590-68124846 bp, - strand From VEGA annotation of GRCm38   42257 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38041  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nefm

Human homologs

Human Homolog		NEFM, neurofilament, medium polypeptide
NCBI Gene ID		4741
neXtProt AC		NX_P07197
Human Synonyms		NEF3, NFM, NF-M
Human Chr (Location)		8p21; chr8:24771274-24776606 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for a knock-out allele exhibit reduced axon diameter.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	axon cargo transport, intermediate filament bundle assembly, ...
Component	axon, cytoplasm, ...
Function	structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (535 records)
Data Summary: Results (821)    Tissues (182)    Images (252)
Theiler Stages: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	540
RNA in situ	163
Western blot	6
RT-PCR	112

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(4) cDNA(17) Primer pair(4) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016378 (Evidence)
Ensembl Gene Model	ENSMUSG00000022054 (Evidence)
Entrez Gene	18040 (Evidence)
NIA Mouse Gene Index	U035719
Consensus CDS Project	CCDS27233.1
International Mouse Knockout Project Status	Nefm

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016378	VEGA Gene Model | MGI Sequence Detail	42257	C57BL/6J
transcript	OTTMUST00000039418	VEGA | MGI Sequence Detail	3334	Not Applicable
polypeptide	OTTMUSP00000017611	VEGA | MGI Sequence Detail	848	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR006821	Intermediate filament head, DNA-binding domain
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR002957	Keratin, type I
Protein Ontology	PR:000011120	neurofilament medium polypeptide

References

(Earliest) J:11960 Julien JP, et al., Cloning and developmental expression of the murine neurofilament gene family. Brain Res Mol Brain Res. 1986 Dec;387(3):243-50
(Latest) J:196080 Elsen GE, et al., The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4081-6
All references(607)

Other accession IDs

MGD-MRK-12832