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Nefm
Gene Detail
 Symbol
Name
ID
Nefm
neurofilament, medium polypeptide
MGI:97314
Synonyms Nef3, neurofilament-M, NF160, NF165, Nfm, NF-M
Feature Type protein coding gene
Genetic Map
Chromosome 14
35.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr14:68082590-68124846 bp, - strand
From VEGA annotation of GRCm38

  42257 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137211  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Nefm

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced axon diameter.
 
Phenotype Images(4)
Interactions
Nefm interacts with 296 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process axon cargo transport, intermediate filament bundle assembly, ...
Component axon, cell, ...
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (558 records)
Data Summary: Results (928)    Tissues (217)    Images (329)
Theiler Stages: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 647
RNA in situ 163
Western blot 6
RT-PCR 112
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(4) cDNA(17) Primer pair(4) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016378 (Evidence)
Ensembl Gene ModelENSMUSG00000022054 (Evidence)
Entrez Gene18040 (Evidence)
NIA Mouse Gene IndexU035719
Consensus CDS ProjectCCDS27233.1
International Mouse Knockout Project StatusNefm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016378 VEGA Gene Model | MGI Sequence Detail 42257 C57BL/6J ±  kb
transcript OTTMUST00000039418 VEGA | MGI Sequence Detail 3334 Not Applicable 
polypeptide OTTMUSP00000017611 VEGA | MGI Sequence Detail 848 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(375 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006821 Intermediate filament head, DNA-binding domain
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR002957 Keratin, type I
Protein Ontology PR:000011120 neurofilament medium polypeptide
References (Earliest) J:11960 Julien JP, et al., Cloning and developmental expression of the murine neurofilament gene family. Brain Res Mol Brain Res. 1986 Dec;387(3):243-50
(Latest) J:207796 Choi HY, et al., APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. Elife. 2013;2:e00220
All references(629)
Other
accession IDs
MGD-MRK-12832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory