Nfe2 MGI Mouse Gene Detail - MGI:97308 - nuclear factor, erythroid derived 2

Nfe2 Gene Detail

Symbol

Nfe2
Name

nuclear factor, erythroid derived 2
Synonyms

NF-E2, p45, p45nf-e2, p45NFE2

Feature Type

protein coding gene
IDs

MGI:97308
NCBI Gene: 18022
Gene Overview

MyGene.info: NFE2

Sequence Map

Chr15:103248212-103258403 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

10192 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 58.62 cM
Mapping Data

3 experiments

Human Ortholog

NFE2, nuclear factor, erythroid 2

Vertebrate Orthologs

8

Human Ortholog

NFE2, nuclear factor, erythroid 2
Orthology source: HomoloGene, HGNC
Synonyms

NF-E2, p45
Links

HGNC:7780

NCBI Gene ID: 4778

neXtProt AC: NX_Q16621

UniProt: Q16621
Chr Location

12q13.13; chr12:54292107-54301037 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 4491
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NFE2
Gene Tree

Nfe2

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Phenotype Summary

24 phenotypes from 1 allele in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Gene trapped

6
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available

Homozygotes for a targeted null mutation lack platelets and most die as neonates from internal bleeding. Survivors exhibit hypochromia, reticulocytosis, and splenomegaly.

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All GO Annotations

22
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

110
Tissues

65
cDNA Data

28
Literature Summary

21

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nfe2

ZFIN nfe2

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Nfe2 interacts with 59 markers (Mir28b, Mir28c, Mir29a, ...) View All

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All Sequences

81
RefSeq

16
UniProt

8
CCDS

CCDS27900.1
UniGene

457989

			Length	Strain/Species	Flank
genomic	OTTMUSG00000034093	VEGA Gene Model \| MGI Sequence Detail	10192	C57BL/6J	± kb
transcript	OTTMUST00000086189	VEGA \| MGI Sequence Detail	1605	Not Applicable
polypeptide	OTTMUSP00000046632	VEGA \| MGI Sequence Detail	396	Not Applicable

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SNPs within 2kb

71 from dbSNP Build 142

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UniProt

8 Sequences
Protein Ontology

PR:000011168 transcription factor NF-E2 45 kDa subunit

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR004826 Basic leucine zipper domain, Maf-type

IPR008917 Transcription factor, Skn-1-like, DNA-binding domain

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All nucleic 34

Genomic 1

cDNA 28

Primer pair 3

Other 2

Microarray probesets 3

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MGD-MRK-12825

Summaries

All 88

Developmental Gene Expression 21

Gene Ontology 9

Phenotypes 35
Earliest

J:31039 Kreimer-Birnbaum M, et al., Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y). Comp Biochem Physiol A. 1972 Sep 1;43(1):21-30
Latest

J:237268 Kohli S, et al., Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts. Blood. 2016 Oct 27;128(17):2153-2164

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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