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Nfe2
Gene Detail
 Symbol
Name
ID
Nfe2
nuclear factor, erythroid derived 2
MGI:97308
Synonyms NF-E2, p45, p45nf-e2, p45NFE2
Feature Type protein coding gene
Genetic Map
Chromosome 15
58.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:103248212-103258403 bp, - strand
From VEGA annotation of GRCm38

  10192 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4491  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Nfe2

Human
homologs
Human Homolog NFE2, nuclear factor, erythroid 2
NCBI Gene ID 4778
neXtProt AC  NX_Q16621
Human Synonyms  NF-E2, p45
Human Chr (Location)  12q13; chr12:54292107-54325085 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation lack platelets and most die as neonates from internal bleeding. Survivors exhibit hypochromia, reticulocytosis, and splenomegaly.
 
Interactions
Nfe2 interacts with 59 markers (Mir28b, Mir28c, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell-cell signaling, labyrinthine layer blood vessel development, ...
Component actin cytoskeleton, cytoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (110)    Tissues (65)    Images (30)
Theiler Stages: 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 78
Northern blot 7
RT-PCR 25
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(1) cDNA(28) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034093 (Evidence)
Ensembl Gene ModelENSMUSG00000058794 (Evidence)
Entrez Gene18022 (Evidence)
UniGene457989
DFCITC1580131
DoTSDT.492748, DT.91442447, DT.99842313
NIA Mouse Gene IndexU117465
Consensus CDS ProjectCCDS27900.1
International Mouse Knockout Project StatusNfe2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034093 VEGA Gene Model | MGI Sequence Detail 10192 C57BL/6J ±  kb
transcript OTTMUST00000086189 VEGA | MGI Sequence Detail 1605 Not Applicable 
polypeptide OTTMUSP00000046632 VEGA | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(16) UniProt(7)
Polymorphisms SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
Protein Ontology PR:000011168 transcription factor NF-E2 45 kDa subunit
References (Earliest) J:31039 Kreimer-Birnbaum M, et al., Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y). Comp Biochem Physiol A. 1972 Sep 1;43(1):21-30
(Latest) J:204483 Fujita R, et al., NF-E2 p45 is important for establishing normal function of platelets. Mol Cell Biol. 2013 Jul;33(14):2659-70
All references(89)
Other
accession IDs
MGD-MRK-12825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory