Nfe2
Gene Detail

Symbol

Name
ID

Nfe2
nuclear factor, erythroid derived 2
MGI:97308

Synonyms

NF-E2, p45, p45nf-e2, p45NFE2

Feature Type

protein coding gene

Genetic Map

Chromosome 15
58.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:103248212-103258403 bp, - strand From VEGA annotation of GRCm38   10192 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4491  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Nfe2

Human
homologs

Human Homolog		NFE2, nuclear factor, erythroid 2
NCBI Gene ID		4778
neXtProt AC		NX_Q16621
Human Synonyms		NF-E2, p45
Human Chr (Location)		12q13; chr12:54292107-54325085 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(12) : Gene trapped(6) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for a targeted null mutation lack platelets and most die as neonates from internal bleeding. Survivors exhibit hypochromia, reticulocytosis, and splenomegaly.

 

Interactions

Nfe2 interacts with 59 markers (Mir28b, Mir28c, Mir29a, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (20 annotations)

Process	cell-cell signaling, labyrinthine layer blood vessel development, ...
Component	actin cytoskeleton, cytoplasm, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (21 records)

Data Summary: Results (110)    Tissues (65)    Images (30)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	78
Northern blot	7
RT-PCR	25

cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(34) Genomic(1) cDNA(28) Primer pair(3) Other(2)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000034093 (Evidence)
Ensembl Gene Model	ENSMUSG00000058794 (Evidence)
Entrez Gene	18022 (Evidence)
UniGene	457989
DFCI	TC1580131, TC1699729
DoTS	DT.101371970, DT.110840516, DT.492748, DT.91442447, DT.97373619, DT.99842313
NIA Mouse Gene Index	U117465
Consensus CDS Project	CCDS27900.1
International Mouse Knockout Project Status	Nfe2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034093	VEGA Gene Model | MGI Sequence Detail	10192	C57BL/6J
transcript	OTTMUST00000086189	VEGA | MGI Sequence Detail	1605	Not Applicable
polypeptide	OTTMUSP00000046632	VEGA | MGI Sequence Detail	396	Not Applicable

All sequences(96) RefSeq(18) UniProt(13)

Polymorphisms

SNPs within 2kb(71 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR004826	Basic leucine zipper domain, Maf-type
InterPro	IPR008917	Eukaryotic transcription factor, Skn-1-like, DNA-binding
Protein Ontology	PR:000011168	transcription factor NF-E2 45 kDa subunit

References

(Earliest) J:31039 Kreimer-Birnbaum M, et al., Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y). Comp Biochem Physiol A. 1972 Sep 1;43(1):21-30
(Latest) J:204483 Fujita R, et al., NF-E2 p45 is important for establishing normal function of platelets. Mol Cell Biol. 2013 Jul;33(14):2659-70
All references(89)

Other
accession IDs

MGD-MRK-12825