About   Help   FAQ
Nfe2 Gene Detail
Summary
  • Symbol
    Nfe2
  • Name
    nuclear factor, erythroid derived 2
  • Synonyms
    NF-E2, p45, p45nf-e2, p45NFE2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97308
    NCBI Gene: 18022
  • Gene Overview
    MyGene.info: NFE2
Location & Maps
more
  • Sequence Map
    Chr15:103248212-103258403 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      10192 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 58.62 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NFE2, nuclear factor, erythroid 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NFE2, nuclear factor, erythroid 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NF-E2, p45
  • Links
    NCBI Gene ID: 4778
    neXtProt AC: NX_Q16621
    UniProt: Q16621

  • Chr Location
    12q13.13; chr12:54292107-54301037 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation lack platelets and most die as neonates from internal bleeding. Survivors exhibit hypochromia, reticulocytosis, and splenomegaly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    110
  • Tissues
    65
  • cDNA Data
    28
  • Literature Summary
    21
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034093 VEGA Gene Model | MGI Sequence Detail 10192 C57BL/6J ±  kb
transcript OTTMUST00000086189 VEGA | MGI Sequence Detail 1605 Not Applicable  
polypeptide OTTMUSP00000046632 VEGA | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    71 from dbSNP Build 142
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000011168 transcription factor NF-E2 45 kDa subunit
    (term hierarchy)
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR004826 Basic leucine zipper domain, Maf-type
    IPR029853 Transcription factor NF-E2, 45kDa subunit
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
Molecular
Reagents
less
  • All nucleic 34
    Genomic 1
    cDNA 28
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12825
References
more
  • Summaries
    All 88
    Developmental Gene Expression 21
    Gene Ontology 9
    Phenotypes 35
  • Earliest
    J:31039 Kreimer-Birnbaum M, et al., Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y). Comp Biochem Physiol A. 1972 Sep 1;43(1):21-30
  • Latest
    J:237268 Kohli S, et al., Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts. Blood. 2016 Oct 27;128(17):2153-2164
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/12/2017
MGI 6.10 		The Jackson Laboratory