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Nfe2 Gene Detail
Summary
  • Symbol
    Nfe2
  • Name
    nuclear factor, erythroid derived 2
  • Synonyms
    NF-E2, p45, p45nf-e2, p45NFE2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97308
    NCBI Gene: 18022
  • Gene Overview
    MyGene.info: NFE2
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:103156639-103166830 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 58.62 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97308
 protein coding gene Chr15:103156639-103166830 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022436
 protein coding gene Chr15:105502581-105512794 (-)
A/J MGP_AJ_G0022398
 protein coding gene Chr15:101331718-101341842 (-)
AKR/J MGP_AKRJ_G0022373
 protein coding gene Chr15:104404277-104414431 (-)
BALB/cJ MGP_BALBcJ_G0022402
 protein coding gene Chr15:101377576-101387800 (-)
C3H/HeJ MGP_C3HHeJ_G0022169
 protein coding gene Chr15:104500871-104511064 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022851
 protein coding gene Chr15:109389187-109399237 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020374
 protein coding gene Chr15:97094137-97104561 (-)
CAST/EiJ MGP_CASTEiJ_G0021695
 protein coding gene Chr15:105369804-105379953 (-)
CBA/J MGP_CBAJ_G0022138
 protein coding gene Chr15:113244057-113254198 (-)
DBA/2J MGP_DBA2J_G0022269
 protein coding gene Chr15:100605036-100615148 (-)
FVB/NJ MGP_FVBNJ_G0022245
 protein coding gene Chr15:99667236-99677797 (-)
LP/J MGP_LPJ_G0022338
 protein coding gene Chr15:105649071-105659199 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022267
 protein coding gene Chr15:116741821-116753160 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022863
 protein coding gene Chr15:104446682-104456814 (-)
PWK/PhJ MGP_PWKPhJ_G0021435
 protein coding gene Chr15:100785009-100795163 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021267
 protein coding gene Chr15:104285195-104290934 (-)
WSB/EiJ MGP_WSBEiJ_G0021745
 protein coding gene Chr15:105065720-105075889 (-)



Homology
more
  • Human Ortholog
    NFE2, nuclear factor, erythroid 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFE2, nuclear factor, erythroid 2
  • Synonyms
    NF-E2, p45
  • Links
    NCBI Gene ID: 4778
    neXtProt AC: NX_Q16621
    UniProt: Q16621

  • Chr Location
    12q13.13; chr12:54292107-54301037 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation lack platelets and most die as neonates from internal bleeding. Survivors exhibit hypochromia, reticulocytosis, and splenomegaly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    70
  • cDNA Data
    29
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18022 NCBI Gene Model | MGI Sequence Detail 10192 C57BL/6J ±  kb
    transcript NM_001302338 RefSeq | MGI Sequence Detail 1896 C57BL/6  
    polypeptide Q07279 UniProt | EBI | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000011168 transcription factor NF-E2 45 kDa subunit
      (term hierarchy)
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR004826 Basic leucine zipper domain, Maf-type
      IPR029853 Transcription factor NF-E2, 45kDa subunit
      IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 29
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12825
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 23
      Gene Ontology 12
      Phenotypes 37
    • Earliest
      J:31039 Kreimer-Birnbaum M, et al., Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y). Comp Biochem Physiol A. 1972 Sep 1;43(1):21-30
    • Latest
      J:275444 Jutzi JS, et al., Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations. Blood. 2019 Apr 18;133(16):1766-1777
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/23/2021
    MGI 6.17     		The Jackson Laboratory