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Nfe2
Gene Detail
Symbol

Name
ID
Nfe2
nuclear factor, erythroid derived 2
MGI:97308
Synonyms
NF-E2, p45, p45nf-e2, p45NFE2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
58.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:103248212-103258403 bp, - strand
From VEGA annotation of GRCm38

  10192 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4491  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: NFE2
Gene Tree: Nfe2

Human
homologs
NFE2, nuclear factor, erythroid 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4778
neXtProt AC: NX_Q16621

Human Synonyms: NF-E2, p45

Human Chr (Location): 12q13; chr12:54292107-54301037 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation lack platelets and most die as neonates from internal bleeding. Survivors exhibit hypochromia, reticulocytosis, and splenomegaly.
 
Interactions
Nfe2 interacts with 59 markers (Mir28b, Mir28c, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell-cell signaling, labyrinthine layer blood vessel development, ...
Component actin cytoskeleton, cytoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (110)    Tissues (65)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 78
Northern blot 7
RT-PCR 25
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nfe2 ; ZFIN nfe2    NEW 
Molecular
reagents
All nucleic(34) Genomic(1) cDNA(28) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034093 (Evidence)
Ensembl Gene Model ENSMUSG00000058794 (Evidence)
Entrez Gene 18022 (Evidence)
UniGene 457989
DFCI TC1580131, TC1699729
DoTS DT.101371970, DT.110840516, DT.492748, DT.91442447, DT.97373619, DT.99842313
NIA Mouse Gene Index U117465
Consensus CDS Project CCDS27900.1
International Mouse Phenotyping Consortium Status Nfe2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034093 VEGA Gene Model | MGI Sequence Detail 10192 C57BL/6J ±  kb
transcript OTTMUST00000086189 VEGA | MGI Sequence Detail 1605 Not Applicable 
polypeptide OTTMUSP00000046632 VEGA | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(18) UniProt(7)
Polymorphisms
SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
Protein Ontology PR:000011168 transcription factor NF-E2 45 kDa subunit
References
(Earliest) J:31039 Kreimer-Birnbaum M, et al., Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y). Comp Biochem Physiol A. 1972 Sep 1;43(1):21-30
(Latest) J:204483 Fujita R, et al., NF-E2 p45 is important for establishing normal function of platelets. Mol Cell Biol. 2013 Jul;33(14):2659-70
All references(87)
Other
accession IDs
MGD-MRK-12825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory