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Nfe2 Gene Detail
Summary
  • Symbol
    Nfe2
  • Name
    nuclear factor, erythroid derived 2
  • Synonyms
    NF-E2, p45, p45nf-e2, p45NFE2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97308
    NCBI Gene: 18022
  • Gene Overview
    MyGene.info: NFE2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr15:103248212-103258403 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      10192 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 58.62 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NFE2, nuclear factor, erythroid 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NFE2, nuclear factor, erythroid 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NF-E2, p45
  • Links
    NCBI Gene ID: 4778
    neXtProt AC: NX_Q16621
    UniProt: Q16621

  • Chr Location
    12q13.13; chr12:54292107-54301037 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 1 allele in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation lack platelets and most die as neonates from internal bleeding. Survivors exhibit hypochromia, reticulocytosis, and splenomegaly.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    110
  • Tissues
    65
  • cDNA Data
    28
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034093 VEGA Gene Model | MGI Sequence Detail 10192 C57BL/6J ±  kb
    transcript OTTMUST00000086189 VEGA | MGI Sequence Detail 1605 Not Applicable  
    polypeptide OTTMUSP00000046632 VEGA | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      71 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR004826 Basic leucine zipper domain, Maf-type
      IPR029853 Transcription factor NF-E2, 45kDa subunit
      IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 28
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12825
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 21
      Gene Ontology 10
      Phenotypes 36
    • Earliest
      J:31039 Kreimer-Birnbaum M, et al., Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y). Comp Biochem Physiol A. 1972 Sep 1;43(1):21-30
    • Latest
      J:246556 Yang W, et al., NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway. Diabetes. 2017 Jul;66(7):1819-1832
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory