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Neu1
Gene Detail
 Symbol
Name
ID
Neu1
neuraminidase 1
MGI:97305
Synonyms Aglp, Apl, Bat7, Bat-7, G9, lysosomal sialidase, Map-2, Neu-1, sialidase 1
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr17:34931253-34935953 bp, + strand
From VEGA annotation of GRCm38

  4701 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:375  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Neu1

Human
homologs
Human Homolog NEU1, sialidase 1 (lysosomal sialidase)
NCBI Gene ID 4758
neXtProt AC  NX_Q99519
Human Synonyms  NANH, NEU, SIAL1
Human Chr (Location)  6p21.3; chr6:31859052-31862932 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NEU1
Alleles
and
phenotypes
All alleles(7) : Targeted(4) Other(3)
 
Nullizygous mice develop features of early-onset lysosomal storage disease (sialidosis), including severe nephropathy, edema, splenomegaly, kyphosis and oligosacchariduria, and display myoclonus, lordosis, extramedullary hematopoiesis, dyspnea, weight loss, gait defects, tremors and premature death.
 
Human Diseases Modeled Using Mouse Neu1 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process carbohydrate metabolic process, lipid catabolic process, ...
Component cell junction, cell surface, ...
Function exo-alpha-(2->3)-sialidase activity, exo-alpha-(2->6)-sialidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (117)    Tissues (101)    Images (13)
Theiler Stages: 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 110
RT-PCR 7
cDNA source data(169)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(175) Genomic(3) cDNA(170) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037276 (Evidence)
Ensembl Gene ModelENSMUSG00000007038 (Evidence)
Entrez Gene18010 (Evidence)
UniGene8856
DFCITC1572949, TC1639805, TC1642176, TC1677449, TC1778992
DoTSDT.101128296, DT.111069065, DT.494582
NIA Mouse Gene IndexU017876
EC3.2.1.18
Consensus CDS ProjectCCDS28668.1
International Mouse Knockout Project StatusNeu1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037276 VEGA Gene Model | MGI Sequence Detail 4701 C57BL/6J ±  kb
transcript OTTMUST00000096159 VEGA | MGI Sequence Detail 2474 Not Applicable 
polypeptide OTTMUSP00000053690 VEGA | MGI Sequence Detail 409 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026942 Sialidase-1
InterPro IPR026856 Sialidase family
InterPro IPR011040 Sialidases
Protein Ontology PR:000011145 sialidase-1
References (Earliest) J:4457 Lalley PA, et al., Lysosomal Acid Phosphatase Deficiency: Liver Specific Variant in the Mouse. Genetics. 1977 Oct;87(2):305-317
(Latest) J:204121 Bonten EJ, et al., Chaperone-mediated gene therapy with recombinant AAV-PPCA in a new mouse model of type I sialidosis. Biochim Biophys Acta. 2013 Oct;1832(10):1784-92
All references(89)
Other
accession IDs
MGD-MRK-1182, MGD-MRK-12114, MGD-MRK-12819, MGD-MRK-12820, MGD-MRK-1358, MGD-MRK-1504, MGD-MRK-1512, MGI:2146738, MGI:2146740, MGI:88131

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory