Neu1
Gene Detail

Symbol Name ID

Neu1 neuraminidase 1 MGI:97305

Synonyms

Aglp, Apl, Bat7, Bat-7, G9, lysosomal sialidase, Map-2, Neu-1, sialidase 1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)

Sequence Map

Chr17:34931253-34935953 bp, + strand From VEGA annotation of GRCm38   4701 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:375  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Neu1

Human homologs

Human Homolog		NEU1, sialidase 1 (lysosomal sialidase)
NCBI Gene ID		4758
neXtProt AC		NX_Q99519
Human Synonyms		NANH, NEU, SIAL1
Human Chr (Location)		6p21.3; chr6:31826829-31830709 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NEU1

Alleles and phenotypes

All alleles(7) : Targeted(4) Other(3)
 

Nullizygous mice develop features of early-onset lysosomal storage disease (sialidosis), including severe nephropathy, edema, splenomegaly, kyphosis and oligosacchariduria, and display myoclonus, lordosis, extramedullary hematopoiesis, dyspnea, weight loss, gait defects, tremors and premature death.

 
Human Diseases Modeled Using Mouse Neu1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	metabolic process, positive regulation of neuron projection development, ...
Component	cell junction, cell surface, ...
Function	exo-alpha-(2->3)-sialidase activity, exo-alpha-(2->6)-sialidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (117)    Tissues (101)    Images (13)
Theiler Stages: 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	110
RT-PCR	7

cDNA source data(169)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(175) Genomic(3) cDNA(170) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037276 (Evidence)
Ensembl Gene Model	ENSMUSG00000007038 (Evidence)
Entrez Gene	18010 (Evidence)
UniGene	8856
DFCI	TC1572949, TC1639805, TC1642176, TC1677449, TC1778992
DoTS	DT.101128296, DT.111069065, DT.494582
NIA Mouse Gene Index	U017876
EC	3.2.1.18
Consensus CDS Project	CCDS28668.1
International Mouse Knockout Project Status	Neu1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037276	VEGA Gene Model | MGI Sequence Detail	4701	C57BL/6J
transcript	OTTMUST00000096159	VEGA | MGI Sequence Detail	2474	Not Applicable
polypeptide	OTTMUSP00000053690	VEGA | MGI Sequence Detail	409	Not Applicable

All sequences(47) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011040	Neuraminidase
InterPro	IPR026942	Sialidase-1
InterPro	IPR026856	Sialidase family
Protein Ontology	PR:000011145	sialidase-1

References

(Earliest) J:4457 Lalley PA, et al., Lysosomal Acid Phosphatase Deficiency: Liver Specific Variant in the Mouse. Genetics. 1977 Oct;87(2):305-317
(Latest) J:190648 Yang A, et al., Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice. J Lipid Res. 2012 Dec;53(12):2573-85
All references(88)

Other accession IDs

MGD-MRK-1182, MGD-MRK-12114, MGD-MRK-12819, MGD-MRK-12820, MGD-MRK-1358, MGD-MRK-1504, MGD-MRK-1512, MGI:2146738, MGI:2146740, MGI:88131