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Neu1 Gene Detail
Summary
  • Symbol
    Neu1
  • Name
    neuraminidase 1
  • Synonyms
    Aglp, Apl, Bat7, Bat-7, G9, lysosomal sialidase, Map-2, Neu-1, sialidase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97305
    NCBI Gene: 18010
  • Gene Overview
    MyGene.info: NEU1
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34931253-34935953 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.48 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97305
 protein coding gene Chr17:34931253-34937297 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023599
 protein coding gene Chr17:35054708-35059403 (+)
A/J MGP_AJ_G0023561
 protein coding gene Chr17:33905439-33910139 (+)
AKR/J MGP_AKRJ_G0023527
 protein coding gene Chr17:34368536-34373236 (+)
BALB/cJ MGP_BALBcJ_G0023566
 protein coding gene Chr17:34033227-34037921 (+)
C3H/HeJ MGP_C3HHeJ_G0023326
 protein coding gene Chr17:34763550-34768250 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024006
 protein coding gene Chr17:36389349-36394049 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021485
 protein coding gene Chr17:31671253-31676341 (+)
CAST/EiJ MGP_CASTEiJ_G0022824
 protein coding gene Chr17:34759773-34764478 (+)
CBA/J MGP_CBAJ_G0023304
 protein coding gene Chr17:37894023-37900382 (+)
DBA/2J MGP_DBA2J_G0023432
 protein coding gene Chr17:33220753-33225453 (+)
FVB/NJ MGP_FVBNJ_G0023399
 protein coding gene Chr17:33052348-33057040 (+)
LP/J MGP_LPJ_G0023509
 protein coding gene Chr17:35384829-35389460 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023422
 protein coding gene Chr17:36832728-36837418 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024048
 protein coding gene Chr17:34593135-34597836 (+)
PWK/PhJ MGP_PWKPhJ_G0022573
 protein coding gene Chr17:32048248-32052939 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022390
 protein coding gene Chr17:32597255-32601940 (+)
WSB/EiJ MGP_WSBEiJ_G0022886
 protein coding gene Chr17:34707629-34712310 (+)



Homology
more
  • Human Ortholog
    NEU1, neuraminidase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NEU1, neuraminidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NANH, NEU, SIAL1
  • Links
    NCBI Gene ID: 4758
    neXtProt AC: NX_Q99519
    UniProt: Q99519

  • Chr Location
    6p21.33; chr6:31859052-31862932 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 375
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NEU1
  • Gene Tree
    Neu1
Human Diseases
more
  • Diseases
    1 with Neu1 mouse models; 1 with human NEU1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice develop features of early-onset lysosomal storage disease (sialidosis), including severe nephropathy, edema, splenomegaly, kyphosis and oligosacchariduria, and display myoclonus, lordosis, extramedullary hematopoiesis, dyspnea, weight loss, gait defects, tremors and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    32
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    117
  • Tissues
    102
  • cDNA Data
    170
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007038 Ensembl Gene Model | MGI Sequence Detail 4701 C57BL/6J ±  kb
    transcript ENSMUST00000007253 Ensembl | MGI Sequence Detail 2474 Not Applicable  
    polypeptide ENSMUSP00000007253 Ensembl | MGI Sequence Detail 409 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 176
      Genomic 3
      cDNA 171
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1182, MGD-MRK-12114, MGD-MRK-12819, MGD-MRK-12820, MGD-MRK-1358, MGD-MRK-1504, MGD-MRK-1512, MGI:2146738, MGI:2146740, MGI:88131
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 6
      Phenotypes 27
    • Earliest
      J:4457 Lalley PA, et al., Lysosomal Acid Phosphatase Deficiency: Liver Specific Variant in the Mouse. Genetics. 1977 Oct;87(2):305-317
    • Latest
      J:274756 Lillehoj EP, et al., Neuraminidase 1-mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection. J Biol Chem. 2019 Jan 11;294(2):662-678
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    01/07/2020
    MGI 6.14     		The Jackson Laboratory