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Nedd9 Gene Detail
Summary
  • Symbol
    Nedd9
  • Name
    neural precursor cell expressed, developmentally down-regulated gene 9
  • Synonyms
    CasL, Cas-L, E230025G09Rik, HEF1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97302
    NCBI Gene: 18003
  • Gene Overview
    MyGene.info: NEDD9
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:41309916-41487360 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      177445 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 20.43 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NEDD9, neural precursor cell expressed, developmentally down-regulated 9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEDD9, neural precursor cell expressed, developmentally down-regulated 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAS2, CASL, CAS-L, CASS2, HEF1
  • Links
    NCBI Gene ID: 4739
    neXtProt AC: NX_Q14511
    UniProt: Q14511

  • Chr Location
    6p24.2; chr6:11183298-11382348 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit impaired lymphocyte trafficking and a deficit of splenic marginal zone B cells. Mice homozygous for another null allele display impaired spatial learning and decreased hippocampal dendritic spine densities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18003 NCBI Gene Model | MGI Sequence Detail 177445 C57BL/6J ±  kb
    transcript NM_001111324 RefSeq | MGI Sequence Detail 4603 C57BL/6  
    polypeptide O35177 UniProt | EBI | MGI Sequence Detail 833 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      924 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 95
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12815, MGI:2442508
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 13
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:229548 Knutson DC, et al., Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment. Brain Res. 2016 Feb 1;1632:141-55

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory