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Nedd9 Gene Detail
Summary
  • Symbol
    Nedd9
  • Name
    neural precursor cell expressed, developmentally down-regulated gene 9
  • Synonyms
    CasL, Cas-L, E230025G09Rik, HEF1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97302
    NCBI Gene: 18003
  • Gene Overview
    MyGene.info: NEDD9
Location & Maps
more
  • Sequence Map
    Chr13:41309916-41487320 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      177405 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NEDD9, neural precursor cell expressed, developmentally down-regulated 9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEDD9, neural precursor cell expressed, developmentally down-regulated 9
    Orthology source: HomoloGene
  • Synonyms
    CAS2, CASL, CAS-L, CASS2, HEF1
  • Links
    NCBI Gene ID: 4739
    neXtProt AC: NX_Q14511

  • Chr Location
    6p24.2; chr6:11183298-11382348 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Nedd9
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit impaired lymphocyte migration and adhesion, decreased lymphocyte cell number in peripheral lymphoid organs, a deficit of splenic marginal zone B cells, and a concomitant increase in follicular B cell number.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021365 Ensembl Gene Model | MGI Sequence Detail 177405 C57BL/6J ±  kb
transcript ENSMUST00000021794 Ensembl | MGI Sequence Detail 4563 Not Applicable  
polypeptide ENSMUSP00000021794 Ensembl | MGI Sequence Detail 833 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    924 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 97
    cDNA 95
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-12815, MGI:2442508
References
more
  • Summaries
    All 38
    Developmental Gene Expression 13
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
  • Latest
    J:221622 Knutson DC, et al., A complex RARE is required for the majority of Nedd9 embryonic expression. Transgenic Res. 2015 Feb;24(1):123-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory