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Nedd9
Gene Detail
Symbol

Name
ID
Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
MGI:97302
Synonyms
CasL, Cas-L, E230025G09Rik, HEF1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
20.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:41309916-41487320 bp, - strand
From Ensembl annotation of GRCm38

  177405 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4669  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Nedd9

Human
homologs
Human Homolog NEDD9, neural precursor cell expressed, developmentally down-regulated 9
NCBI Gene ID 4739
neXtProt AC  NX_Q14511
Human Synonyms  CAS2, CASL, CAS-L, CASS2, HEF1
Human Chr (Location)  6p25-p24; chr6:11183298-11382348 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit impaired lymphocyte migration and adhesion, decreased lymphocyte cell number in peripheral lymphoid organs, a deficit of splenic marginal zone B cells, and a concomitant increase in follicular B cell number.
 
Interactions
Nedd9 interacts with 323 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell adhesion, cell cycle, ...
Component cytoplasm, cytoskeleton, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (322)    Tissues (106)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 274
Western blot 8
RT-PCR 10
cDNA source data(95)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(97) cDNA(95) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000021365 (Evidence)
Entrez Gene18003 (Evidence)
UniGene288980
DFCITC1575496, TC1720237, TC1749448
DoTSDT.101168053, DT.101736231, DT.533387
NIA Mouse Gene IndexU034715
Consensus CDS ProjectCCDS36640.2, CCDS49247.1
International Mouse Knockout Project StatusNedd9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021365 Ensembl Gene Model | MGI Sequence Detail 177405 C57BL/6J ±  kb
transcript ENSMUST00000021794 Ensembl | MGI Sequence Detail 4563 Not Applicable 
polypeptide ENSMUSP00000021794 Ensembl | MGI Sequence Detail 833 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(926 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021901 CAS family, DUF3513
InterPro IPR014928 Serine rich protein interaction
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000011117 enhancer of filamentation 1
References
(Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:213067 Riccomagno MM, et al., Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Neuron. 2014 Feb 19;81(4):779-86
All references(39)
Other
accession IDs
MGD-MRK-12815, MGI:2442508

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory