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Nedd8
Gene Detail
Symbol

Name
ID
Nedd8
neural precursor cell expressed, developmentally down-regulated gene 8
MGI:97301
Synonyms
Rub1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:55662267-55671906 bp, - strand
From NCBI annotation of GRCm38

  9640 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4485  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: NEDD8
Gene Tree: Nedd8

Human
homologs
NEDD8, neural precursor cell expressed, developmentally down-regulated 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4738
neXtProt AC: NX_Q15843

Human Synonyms: NEDD-8

Human Chr (Location): 14q12; chr14:24216851-24232370 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(30) Targeted(2)
Interactions
Nedd8 interacts with 66 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process protein localization, protein neddylation, ...
Component extracellular exosome, nucleus
Function protein binding, ubiquitin protein ligase binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (97)    Tissues (84)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 72
Northern blot 15
Western blot 10
cDNA source data(139)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nedd8 ; ZFIN nedd8    NEW 
Molecular
reagents
All nucleic(144) Genomic(4) cDNA(140)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000010376 (Evidence)
Entrez Gene 18002 (Evidence)
UniGene 296566
DFCI TC1572517, TC1596644
NIA Mouse Gene Index U035583
Consensus CDS Project CCDS49498.1
International Mouse Phenotyping Consortium Status Nedd8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18002 NCBI Gene Model | MGI Sequence Detail 9640 C57BL/6J ±  kb
transcript NM_008683 RefSeq | MGI Sequence Detail 602 C57BL/6 
polypeptide P29595 UniProt | EBI | MGI Sequence Detail 81 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000626 Ubiquitin
InterPro IPR019954 Ubiquitin conserved site
InterPro IPR019956 Ubiquitin subgroup
Protein Ontology PR:000011116 NEDD8 protein
Graphical View of Protein Domain Structure
References
(Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:219561 Batuello CN, et al., Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1749-54
All references(39)
Other
accession IDs
MGD-MRK-12814

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory