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Nedd8 Gene Detail
Summary
  • Symbol
    Nedd8
  • Name
    neural precursor cell expressed, developmentally down-regulated gene 8
  • Synonyms
    Rub1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97301
    NCBI Gene: 18002
  • Gene Overview
    MyGene.info: NEDD8
Location & Maps
more
  • Sequence Map
    Chr14:55662267-55671906 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9640 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NEDD8, neural precursor cell expressed, developmentally down-regulated 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEDD8, neural precursor cell expressed, developmentally down-regulated 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NEDD-8
  • Links
    NCBI Gene ID: 4738
    neXtProt AC: NX_Q15843

  • Chr Location
    14q12; chr14:24216851-24232370 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4485
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: NEDD8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    33
  • Chemically induced (other)
    1
  • Gene trapped
    30
  • Targeted
    2
  • Genomic Mutations
    1 involving Nedd8
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18002 NCBI Gene Model | MGI Sequence Detail 9640 C57BL/6J ±  kb
transcript NM_008683 RefSeq | MGI Sequence Detail 602 C57BL/6  
polypeptide P29595 UniProt | EBI | MGI Sequence Detail 81 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    17 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 144
    Genomic 4
    cDNA 140

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12814
References
more
  • Summaries
    All 40
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
  • Latest
    J:226978 Tateossian H, et al., Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung. Dis Model Mech. 2015 Dec 1;8(12):1531-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory