Sept2
Gene Detail

Symbol Name ID

Sept2 septin 2 MGI:97298

Synonyms

mKIAA0158, Nedd5

Feature Type

protein coding gene

Genetic Map

Chromosome 1

47.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:93478964-93510260 bp, + strand From VEGA annotation of GRCm38   31297 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3243  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: septin
Gene Tree: Sept2

Human homologs

Human Homolog		SEPT2, septin 2
NCBI Gene ID		4735
neXtProt AC		NX_Q15019
Human Synonyms		DIFF6, hNedd5, NEDD5, Pnutl3
Human Chr (Location)		2q37; chr2:242254723-242293442 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(57) : Targeted(1) Gene trapped(56)

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	cell cycle, cell division, ...
Component	actin cytoskeleton, actomyosin contractile ring, ...
Function	enzyme regulator activity, GTPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (43)    Tissues (11)    Images (28)
Theiler Stages: 15, 17, 20, 21, 23, 25, 28

Assay Type	Results
RNA in situ	28
Western blot	10
RT-PCR	5

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021857 (Evidence)
Ensembl Gene Model	ENSMUSG00000026276 (Evidence)
Entrez Gene	18000 (Evidence)
DFCI	TC1573088, TC1643765, TC1688087, TC1738115
DoTS	DT.101404357, DT.101404365, DT.483572, DT.91286356, DT.94245956, DT.99865353, DT.99865354
NIA Mouse Gene Index	U000632
PDB	3FTQ
Consensus CDS Project	CCDS15190.1, CCDS48328.1
International Mouse Knockout Project Status	Sept2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021857	VEGA Gene Model | MGI Sequence Detail	31297	C57BL/6J
transcript	OTTMUST00000051865	VEGA | MGI Sequence Detail	3779	Not Applicable
polypeptide	OTTMUSP00000024480	VEGA | MGI Sequence Detail	361	Not Applicable

All sequences(102) RefSeq(8) UniProt(10)

Polymorphisms

SNPs(119 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000038	Cell division protein GTP binding
InterPro	IPR016491	Septin
InterPro	IPR008113	Septin 2
Protein Ontology	PR:000014654	septin-2

References

(Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:186260 Yoshida A, et al., Localization of septin proteins in the mouse cochlea. Hear Res. 2012 Jul;289(1-2):40-51
All references(48)

Other accession IDs

MGD-MRK-12811, MGI:2138573