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Sept2
Gene Detail
 Symbol
Name
ID
Sept2
septin 2
MGI:97298
Synonyms mKIAA0158, Nedd5
Feature Type protein coding gene
Genetic Map
Chromosome 1
47.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:93478964-93510260 bp, + strand
From VEGA annotation of GRCm38

  31297 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3243  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: septin
Gene Tree: Sept2

Human
homologs
Human Homolog SEPT2, septin 2
NCBI Gene ID 4735
neXtProt AC  NX_Q15019
Human Synonyms  DIFF6, hNedd5, NEDD5, NEDD-5, Pnutl3
Human Chr (Location)  2q37; chr2:241315187-241354027 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(57) : Gene trapped(56) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Sept2 interacts with 315 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process cell cycle, cell division, ...
Component actin cytoskeleton, actomyosin contractile ring, ...
Function enzyme regulator activity, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (43)    Tissues (12)    Images (28)
Theiler Stages: 15, 17, 20, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 28
Western blot 10
RT-PCR 5
cDNA source data(247)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(249) cDNA(247) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021857 (Evidence)
Ensembl Gene ModelENSMUSG00000026276 (Evidence)
Entrez Gene18000 (Evidence)
UniGene428652
DFCITC1573088, TC1643765, TC1688087, TC1738115
DoTSDT.483572, DT.101404357, DT.101404365, DT.91286356, DT.94245956, DT.99865353, DT.99865354
NIA Mouse Gene IndexU000632
PDB3FTQ
Consensus CDS ProjectCCDS15190.1, CCDS48328.1
International Mouse Knockout Project StatusSept2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021857 VEGA Gene Model | MGI Sequence Detail 31297 C57BL/6J ±  kb
transcript OTTMUST00000051865 VEGA | MGI Sequence Detail 3779 Not Applicable 
polypeptide OTTMUSP00000024480 VEGA | MGI Sequence Detail 361 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(16) UniProt(10)
Polymorphisms SNPs within 2kb(140 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000038 Cell division protein GTP binding
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR016491 Septin
InterPro IPR008113 Septin 2
Protein Ontology PR:000014654 septin-2
References (Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:208280 Bai X, et al., Novel septin 9 repeat motifs altered in neuralgic amyotrophy bind and bundle microtubules. J Cell Biol. 2013 Dec 23;203(6):895-905
All references(51)
Other
accession IDs
MGD-MRK-12811, MGI:2138573

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory