Nedd4 MGI Mouse Gene Detail - MGI:97297 - neural precursor cell expressed, developmentally down-regulated 4

Symbol

Nedd4
Name

neural precursor cell expressed, developmentally down-regulated 4
Synonyms

E430025J12Rik, mKIAA0093, Nedd4, Nedd4-1, Nedd4a

Feature Type

protein coding gene
IDs

MGI:97297
NCBI Gene: 17999
Alliance

gene page
Transcription Start Sites

26 TSS

Sequence Map

Chr9:72569628-72657134 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 40.08 cM
Mapping Data

4 experiments

SNPs within 2kb

2510 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97297	protein coding gene	Chr9:72569613-72657134 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035017	protein coding gene	Chr9:72835929-72931075 (+)
A/J	MGP_AJ_G0034998	protein coding gene	Chr9:70302630-70390612 (+)
AKR/J	MGP_AKRJ_G0034927	protein coding gene	Chr9:71983649-72081302 (+)
BALB/cJ	MGP_BALBcJ_G0034990	protein coding gene	Chr9:70011888-70102288 (+)
C3H/HeJ	MGP_C3HHeJ_G0034699	protein coding gene	Chr9:72481621-72570185 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035509	protein coding gene	Chr9:74739534-74838220 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032420	protein coding gene	Chr9:69793925-69881443 (+)
CAST/EiJ	MGP_CASTEiJ_G0034021	protein coding gene	Chr9:72802147-72895928 (+)
CBA/J	MGP_CBAJ_G0034672	protein coding gene	Chr9:77358794-77458668 (+)
DBA/2J	MGP_DBA2J_G0034831	protein coding gene	Chr9:70020078-70108812 (+)
FVB/NJ	MGP_FVBNJ_G0034773	protein coding gene	Chr9:69333413-69421520 (+)
LP/J	MGP_LPJ_G0034912	protein coding gene	Chr9:73053630-73149375 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034814	protein coding gene	Chr9:78454816-78553326 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035531	protein coding gene	Chr9:72127656-72222440 (+)
PWK/PhJ	MGP_PWKPhJ_G0033725	protein coding gene	Chr9:70296595-70386070 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033558	protein coding gene	Chr9:72427343-72519712 (+)
WSB/EiJ	MGP_WSBEiJ_G0034133	protein coding gene	Chr9:72060171-72149792 (+)

Human Ortholog

NEDD4, NEDD4 E3 ubiquitin protein ligase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NEDD4, NEDD4 E3 ubiquitin protein ligase
Synonyms

NEDD4-1, RPF1
Links

HGNC:7727

NCBI Gene ID: 4734

UniProt: P46934
Chr Location

15q21.3; chr15:55826917-55993660 (-) GRCh38

MGI Vertebrate Homology

Nedd4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NEDD4
Protein SuperFamily

E3_ub_ligase_SMURF1
Gene Tree

Nedd4

less

Phenotype Summary

84 phenotypes from 8 alleles in 7 genetic backgrounds
3 phenotypes from multigenic genotypes
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

142
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

132
Targeted

6
Genomic Mutations

1 involving Nedd4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

115 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development. Mice homozygous for a gene trapped allele on a B6 congenic background exhibit male to female sex reversal and lethality through fetal development.

less

All GO Annotations

193
GO References

33

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1238
Tissues

155
cDNA Data

46
Literature Summary

30

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nedd4

less

All Sequences

98
RefSeq

6
UniProt

12
CCDS

CCDS72275.1

Ensembl

ENSMUSG00000032216 (Evidence)
NCBI Gene

17999

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032216	Ensembl Gene Model \| MGI Sequence Detail	87507	C57BL/6J	± kb
transcript	ENSMUST00000238315	Ensembl \| MGI Sequence Detail	6035	Not Applicable
polypeptide	ENSMUSP00000158796	Ensembl \| MGI Sequence Detail	1136	Not Applicable

less

UniProt

12 Sequences
Protein Ontology

PR:000011115 E3 ubiquitin-protein ligase NEDD4

(term hierarchy)
PDB

3M7F
EC

2.3.2.26
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR050409 E3 ubiquitin-protein ligase

IPR024928 E3 ubiquitin-protein ligase, SMURF1 type

IPR000569 HECT domain

IPR035983 HECT, E3 ligase catalytic domain

IPR001202 WW domain

IPR036020 WW domain superfamily
GlyGen

P46935 4 sites, 1 O-linked glycan (4 sites)

less

All nucleic 54

cDNA 49

Primer pair 4

Other 1

Microarray probesets 5

less

MGD-MRK-12810, MGI:2142966, MGI:2143178, MGI:2143207, MGI:2443188

Summaries

All 139

Developmental Gene Expression 30

Gene Ontology 33

Phenotypes 44
Earliest

J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
Latest

J:361256 Fimiani C, et al., The E3 ubiquitin ligase Nedd4 fosters developmental myelination in the mouse central and peripheral nervous system. Glia. 2025 Feb;73(2):422-444

TSS for Nedd4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86018	Chr9:72569263-72569294 (+)	-349 bp
Tssr86019	Chr9:72569683-72569694 (+)	61 bp
Tssr86020	Chr9:72569702-72569750 (+)	98 bp
Tssr86021	Chr9:72569755-72569805 (+)	152 bp
Tssr86022	Chr9:72571037-72571051 (+)	1,416 bp
Tssr86023	Chr9:72577266-72577286 (+)	7,648 bp
Tssr86024	Chr9:72577314-72577338 (+)	7,698 bp
Tssr86025	Chr9:72577339-72577362 (+)	7,723 bp
Tssr86026	Chr9:72578529-72578555 (+)	8,914 bp
Tssr86027	Chr9:72583846-72583855 (+)	14,223 bp
Tssr86028	Chr9:72586411-72586414 (+)	16,785 bp
Tssr86029	Chr9:72586541-72586545 (+)	16,915 bp
Tssr86034	Chr9:72626429-72626433 (+)	56,803 bp
Tssr86035	Chr9:72628810-72628839 (+)	59,197 bp
Tssr86036	Chr9:72642436-72642492 (+)	72,836 bp
Tssr86037	Chr9:72644148-72644169 (+)	74,531 bp
Tssr86038	Chr9:72649949-72649970 (+)	80,332 bp
Tssr86039	Chr9:72653714-72653734 (+)	84,096 bp
Tssr86040	Chr9:72655277-72655307 (+)	85,664 bp
Tssr86041	Chr9:72656242-72656262 (+)	86,624 bp
Tssr86042	Chr9:72656294-72656316 (+)	86,677 bp
Tssr86043	Chr9:72656378-72656396 (+)	86,759 bp
Tssr86044	Chr9:72656583-72656596 (+)	86,962 bp
Tssr86045	Chr9:72656657-72656675 (+)	87,038 bp
Tssr86046	Chr9:72656698-72656725 (+)	87,084 bp
Tssr86047	Chr9:72656831-72656856 (+)	87,216 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24