Nedd4 MGI Mouse Gene Detail - MGI:97297 - neural precursor cell expressed, developmentally down-regulated 4

Nedd4 Gene Detail

Symbol

Nedd4
Name

neural precursor cell expressed, developmentally down-regulated 4
Synonyms

E430025J12Rik, mKIAA0093, Nedd4, Nedd4-1, Nedd4a

Feature Type

protein coding gene
IDs

MGI:97297
NCBI Gene: 17999
Gene Overview

MyGene.info: NEDD4

Sequence Map

Chr9:72662346-72749852 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

87507 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 40.08 cM
Mapping Data

4 experiments

Human Ortholog

NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

Vertebrate Orthologs

4

Human Ortholog

NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Orthology source: HGNC
Synonyms

NEDD4-1, RPF1
Links

HGNC:7727

NCBI Gene ID: 4734

neXtProt AC: NX_P46934

UniProt: P46934
Chr Location

15q21.3; chr15:55826917-55993746 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 134533
1 mouse;1 rat;1 chimpanzee;1 zebrafish
HCOP

human homology predictions: NEDD4
Protein SuperFamily

E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree

Nedd4

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Phenotype Summary

27 phenotypes from 7 alleles in 5 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

158
Chemically induced (other)

1
Gene trapped

151
Targeted

6
Genomic Mutations

1 involving Nedd4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

104 strains or lines available

Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development.

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All GO Annotations

52
GO References

24

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

430
Tissues

89
cDNA Data

36
Literature Summary

23

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nedd4

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Nedd4 interacts with 315 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

80
RefSeq

4
UniProt

9
CCDS

CCDS72275.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000044728	VEGA Gene Model \| MGI Sequence Detail	87507	C57BL/6J	± kb
transcript	OTTMUST00000117592	VEGA \| MGI Sequence Detail	5499	Not Applicable
polypeptide	OTTMUSP00000065729	VEGA \| MGI Sequence Detail	887	Not Applicable

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SNPs within 2kb

282 from dbSNP Build 142

RFLP

1

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UniProt

9 Sequences
Protein Ontology

PR:000011115 E3 ubiquitin-protein ligase NEDD4

(term hierarchy)
PDB

3M7F
EC

2.3.2.26
InterPro Domains

IPR000008 C2 domain

IPR024928 E3 ubiquitin-protein ligase, SMURF1 type

IPR000569 HECT domain

IPR001202 WW domain

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All nucleic 42

cDNA 39

Primer pair 3

Microarray probesets 5

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MGD-MRK-12810, MGI:2142966, MGI:2143178, MGI:2143207, MGI:2443188

Summaries

All 93

Developmental Gene Expression 23

Gene Ontology 24

Phenotypes 27
Earliest

J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
Latest

J:237670 D'Cruz R, et al., PDLIM7 is a novel target of the ubiquitin ligase Nedd4-1 in skeletal muscle. Biochem J. 2016 Feb 01;473(3):267-76

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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