Nedd4
Gene Detail

Symbol Name ID

Nedd4 neural precursor cell expressed, developmentally down-regulated 4 MGI:97297

Synonyms

E430025J12Rik, mKIAA0093, Nedd4, Nedd4-1, Nedd4a

Feature Type

protein coding gene

Genetic Map

Chromosome 9

40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:72662557-72749842 bp, + strand From Ensembl annotation of GRCm38   87286 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee    (Mammalian Orthology)
Comparative Map (Mouse/Human Nedd4 ± 2 cM)

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Nedd4

Human ortholog

NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase NCBI Gene ID 4734
Human Synonyms: NEDD4-1, RPF1
Human Chr15:56119120-56285835 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(157) : Targeted(5) Gene trapped(152)
 

Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development.

 

Gene Ontology (GO) classifications

All GO classifications: (81 annotations)

Process	adaptive immune response, blood vessel morphogenesis, ...
Component	cell cortex, chromatin, ...
Function	beta-2 adrenergic receptor binding, ligase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (422)    Tissues (81)    Images (57)
Theiler Stages: 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	367
Northern blot	10
RT-PCR	33

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) cDNA(39) Primer pair(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000032216 (Evidence)
Entrez Gene	17999 (Evidence)
DFCI	TC1573666, TC1601002, TC1604410, TC1688850
DoTS	DT.101214246, DT.101234635, DT.101234637, DT.101237517, DT.101329721, DT.101341622, DT.103584967, DT.110584689, DT.87029185, DT.91290439, DT.94225967, DT.94225990, DT.94244436
NIA Mouse Gene Index	U010725
EC	6.3.2.-
PDB	3M7F
International Mouse Knockout Project Status	Nedd4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032216	Ensembl Gene Model | MGI Sequence Detail	87286	C57BL/6J
transcript	ENSMUST00000034740	Ensembl | MGI Sequence Detail	5278	Not Applicable
polypeptide	ENSMUSP00000034740	Ensembl | MGI Sequence Detail	887	Not Applicable

All sequences(65) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(225 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR020477	C2 domain
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
InterPro	IPR000569	HECT
InterPro	IPR001202	WW/Rsp5/WWP
Protein Ontology	PR:000011115	E3 ubiquitin-protein ligase NEDD4

References

(Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:192160 Nagpal P, et al., The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice. PLoS One. 2012;7(10):e46427
All references(82)

Other accession IDs

MGD-MRK-12810, MGI:2142966, MGI:2143178, MGI:2143207, MGI:2443188