Nedd4
Gene Detail

Symbol

Name
ID

Nedd4
neural precursor cell expressed, developmentally down-regulated 4
MGI:97297

Synonyms

E430025J12Rik, mKIAA0093, Nedd4, Nedd4-1, Nedd4a

Feature Type

protein coding gene

Genetic Map

Chromosome 9
40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:72662346-72749852 bp, + strand From VEGA annotation of GRCm38   87507 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:134533  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Nedd4

Mutations,
alleles, and
phenotypes

All mutations/alleles(157) : Gene trapped(152) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development.

 

Interactions

Nedd4 interacts with 316 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (59 annotations)

Process	adaptive immune response, blood vessel morphogenesis, ...
Component	cytoplasm, cytosol, ...
Function	coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (22 records)

Data Summary: Results (422)    Tissues (83)    Images (57)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	12
RNA in situ	367
Northern blot	10
RT-PCR	33

cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(42) cDNA(39) Primer pair(3)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000044728 (Evidence)
Ensembl Gene Model	ENSMUSG00000032216 (Evidence)
Entrez Gene	17999 (Evidence)
DFCI	TC1573666, TC1601002, TC1604410, TC1688850
DoTS	DT.101214246, DT.101234635, DT.101234637, DT.101237517, DT.101329721, DT.101341622, DT.103584967, DT.110584689, DT.87029185, DT.91290439, DT.94225967, DT.94225990, DT.94244436
NIA Mouse Gene Index	U010725
EC	6.3.2.-
PDB	3M7F
Consensus CDS Project	CCDS72275.1
International Mouse Knockout Project Status	Nedd4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000044728	VEGA Gene Model | MGI Sequence Detail	87507	C57BL/6J
transcript	OTTMUST00000117592	VEGA | MGI Sequence Detail	5499	Not Applicable
polypeptide	OTTMUSP00000065729	VEGA | MGI Sequence Detail	887	Not Applicable

All sequences(99) RefSeq(4) UniProt(9)

Polymorphisms

RFLP(1) : SNPs within 2kb(298 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
InterPro	IPR000569	HECT
InterPro	IPR001202	WW domain
Protein Ontology	PR:000011115	E3 ubiquitin-protein ligase NEDD4

References

(Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:216394 Hsia HE, et al., Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13205-10
All references(91)

Other
accession IDs

MGD-MRK-12810, MGI:2142966, MGI:2143178, MGI:2143207, MGI:2443188