About   Help   FAQ
Nedd4
Gene Detail
Symbol

Name
ID
Nedd4
neural precursor cell expressed, developmentally down-regulated 4
MGI:97297
Synonyms
E430025J12Rik, mKIAA0093, Nedd4, Nedd4-1, Nedd4a
Feature Type
protein coding gene
Genetic Map
Chromosome 9
40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:72662346-72749852 bp, + strand
From VEGA annotation of GRCm38

  87507 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134533  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 zebrafish

HCOP human homology predictions: NEDD4
Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Nedd4

Human
homologs
NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Orthology source: HGNC

IDs:
NCBI Gene ID: 4734
neXtProt AC: NX_P46934

Human Synonyms: NEDD4-1, RPF1

Human Chr (Location): 15q; chr15:55826917-55993746 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(157) : Gene trapped(152) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development.
 
Interactions
Nedd4 interacts with 315 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (22 records)
Data Summary: Results (422)    Tissues (83)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 367
Northern blot 10
RT-PCR 33
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nedd4    NEW 
Molecular
reagents
All nucleic(42) cDNA(39) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000044728 (Evidence)
Ensembl Gene Model ENSMUSG00000032216 (Evidence)
Entrez Gene 17999 (Evidence)
DFCI TC1573666, TC1601002, TC1604410, TC1688850
DoTS DT.101214246, DT.101234635, DT.101234637, DT.101237517, DT.101329721, DT.101341622, DT.103584967, DT.110584689, DT.87029185, DT.91290439, DT.94225967, DT.94225990, DT.94244436
NIA Mouse Gene Index U010725
EC 6.3.2.-
PDB 3M7F
Consensus CDS Project CCDS72275.1
International Mouse Phenotyping Consortium Status Nedd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044728 VEGA Gene Model | MGI Sequence Detail 87507 C57BL/6J ±  kb
transcript OTTMUST00000117592 VEGA | MGI Sequence Detail 5499 Not Applicable 
polypeptide OTTMUSP00000065729 VEGA | MGI Sequence Detail 887 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(4) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(298 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000569 HECT
InterPro IPR001202 WW domain
Protein Ontology PR:000011115 E3 ubiquitin-protein ligase NEDD4
References
(Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:216394 Hsia HE, et al., Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13205-10
All references(88)
Other
accession IDs
MGD-MRK-12810, MGI:2142966, MGI:2143178, MGI:2143207, MGI:2443188

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory