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Nedd4 Gene Detail
Summary
  • Symbol
    Nedd4
  • Name
    neural precursor cell expressed, developmentally down-regulated 4
  • Synonyms
    E430025J12Rik, mKIAA0093, Nedd4, Nedd4-1, Nedd4a
  • Feature Type
    protein coding gene
  • IDs
    MGI:97297
    NCBI Gene: 17999
  • Gene Overview
    MyGene.info: NEDD4
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:72569628-72657134 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 40.08 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    276 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97297
 protein coding gene Chr9:72569613-72657134 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035017
 protein coding gene Chr9:72835929-72931075 (+)
A/J MGP_AJ_G0034998
 protein coding gene Chr9:70302630-70390612 (+)
AKR/J MGP_AKRJ_G0034927
 protein coding gene Chr9:71983649-72081302 (+)
BALB/cJ MGP_BALBcJ_G0034990
 protein coding gene Chr9:70011888-70102288 (+)
C3H/HeJ MGP_C3HHeJ_G0034699
 protein coding gene Chr9:72481621-72570185 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035509
 protein coding gene Chr9:74739534-74838220 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032420
 protein coding gene Chr9:69793925-69881443 (+)
CAST/EiJ MGP_CASTEiJ_G0034021
 protein coding gene Chr9:72802147-72895928 (+)
CBA/J MGP_CBAJ_G0034672
 protein coding gene Chr9:77358794-77458668 (+)
DBA/2J MGP_DBA2J_G0034831
 protein coding gene Chr9:70020078-70108812 (+)
FVB/NJ MGP_FVBNJ_G0034773
 protein coding gene Chr9:69333413-69421520 (+)
LP/J MGP_LPJ_G0034912
 protein coding gene Chr9:73053630-73149375 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034814
 protein coding gene Chr9:78454816-78553326 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035531
 protein coding gene Chr9:72127656-72222440 (+)
PWK/PhJ MGP_PWKPhJ_G0033725
 protein coding gene Chr9:70296595-70386070 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033558
 protein coding gene Chr9:72427343-72519712 (+)
WSB/EiJ MGP_WSBEiJ_G0034133
 protein coding gene Chr9:72060171-72149792 (+)



Homology
more
  • Human Ortholog
    NEDD4, NEDD4 E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEDD4, NEDD4 E3 ubiquitin protein ligase
  • Synonyms
    NEDD4-1, RPF1
  • Links
    NCBI Gene ID: 4734
    neXtProt AC: NX_P46934
    UniProt: P46934

  • Chr Location
    15q21.3; chr15:55826917-55993746 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 8 alleles in 6 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    107
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1143
  • Tissues
    146
  • cDNA Data
    45
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032216 Ensembl Gene Model | MGI Sequence Detail 87507 C57BL/6J ±  kb
    transcript ENSMUST00000238315 Ensembl | MGI Sequence Detail 6035 Not Applicable  
    polypeptide ENSMUSP00000158796 Ensembl | MGI Sequence Detail 1136 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 48
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12810, MGI:2142966, MGI:2143178, MGI:2143207, MGI:2443188
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 25
      Gene Ontology 26
      Phenotypes 34
    • Earliest
      J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
    • Latest
      J:299106 Ding X, et al., The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation. Genes Dev. 2020 Sep 1;34(17-18):1177-1189
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/14/2021
    MGI 6.17     		The Jackson Laboratory