Nedd4
Gene Detail

Symbol Name ID

Nedd4 neural precursor cell expressed, developmentally down-regulated 4 MGI:97297

Synonyms

E430025J12Rik, mKIAA0093, Nedd4, Nedd4-1, Nedd4a

Feature Type

protein coding gene

Genetic Map

Chromosome 9

40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:72662346-72749852 bp, + strand From VEGA annotation of GRCm38   87507 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:88807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Nedd4

Human homologs

Human Homolog		NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NCBI Gene ID		4734
neXtProt AC		NX_P46934
Human Synonyms		NEDD4-1, RPF1
Human Chr (Location)		15q; chr15:55826917-55993746 (-)  GRCh38

Alleles and phenotypes

All alleles(157) : Targeted(5) Gene trapped(152)
 

Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development.

 

Gene Ontology (GO) classifications

All GO classifications: (80 annotations)

Process	adaptive immune response, blood vessel morphogenesis, ...
Component	cell cortex, chromatin, ...
Function	beta-2 adrenergic receptor binding, ligase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (20 records)

Data Summary: Results (422)    Tissues (81)    Images (57)
Theiler Stages: 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	367
Northern blot	10
RT-PCR	33

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) cDNA(39) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000044728 (Evidence)
Ensembl Gene Model	ENSMUSG00000032216 (Evidence)
Entrez Gene	17999 (Evidence)
DFCI	TC1573666, TC1601002, TC1604410, TC1688850
DoTS	DT.101214246, DT.101234635, DT.101234637, DT.101237517, DT.101329721, DT.101341622, DT.103584967, DT.110584689, DT.87029185, DT.91290439, DT.94225967, DT.94225990, DT.94244436
NIA Mouse Gene Index	U010725
EC	6.3.2.-
PDB	3M7F
International Mouse Knockout Project Status	Nedd4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000044728	VEGA Gene Model | MGI Sequence Detail	87507	C57BL/6J
transcript	OTTMUST00000117592	VEGA | MGI Sequence Detail	5499	Not Applicable
polypeptide	OTTMUSP00000065729	VEGA | MGI Sequence Detail	887	Not Applicable

All sequences(97) RefSeq(2) UniProt(9)

Polymorphisms

RFLP(1) : SNPs within 2kb(298 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
InterPro	IPR000569	HECT
InterPro	IPR001202	WW domain
Protein Ontology	PR:000011115	E3 ubiquitin-protein ligase NEDD4

References

(Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:196025 Guo H, et al., E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity. Cell Rep. 2012 May 31;1(5):472-82
All references(83)

Other accession IDs

MGD-MRK-12810, MGI:2142966, MGI:2143178, MGI:2143207, MGI:2443188