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Nedd4 Gene Detail
Summary
  • Symbol
    Nedd4
  • Name
    neural precursor cell expressed, developmentally down-regulated 4
  • Synonyms
    E430025J12Rik, mKIAA0093, Nedd4, Nedd4-1, Nedd4a
  • Feature Type
    protein coding gene
  • IDs
    MGI:97297
    NCBI Gene: 17999
  • Gene Overview
    MyGene.info: NEDD4
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr9:72662346-72749852 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      87507 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 40.08 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    4
  • Human Ortholog
    NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
    Orthology source: HGNC
  • Synonyms
    NEDD4-1, RPF1
  • Links
    NCBI Gene ID: 4734
    neXtProt AC: NX_P46934
    UniProt: P46934

  • Chr Location
    15q21.3; chr15:55826917-55993746 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 7 alleles in 5 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in neonatal lethality and heterozygous mice have decreased body weights. Mice homozygous for a knockout allele exhibit impaired neurite development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    469
  • Tissues
    115
  • cDNA Data
    45
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000044728 VEGA Gene Model | MGI Sequence Detail 87507 C57BL/6J ±  kb
    transcript OTTMUST00000117592 VEGA | MGI Sequence Detail 5499 Not Applicable  
    polypeptide OTTMUSP00000065729 VEGA | MGI Sequence Detail 887 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      282 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 48
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12810, MGI:2142966, MGI:2143178, MGI:2143207, MGI:2443188
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 23
      Gene Ontology 25
      Phenotypes 30
    • Earliest
      J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
    • Latest
      J:255082 Kurogi S, et al., Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Sci Rep. 2017 Jan 20;7:40692
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory