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Casp2
Gene Detail
 Symbol
Name
ID
Casp2
caspase 2
MGI:97295
Synonyms Caspase-2, Ich-1, Nedd2
Feature Type protein coding gene
Genetic Map
Chromosome 6
20.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:42264985-42282508 bp, + strand
From VEGA annotation of GRCm38

  17524 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7254  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp2

Human
homologs
Human Homolog CASP2, caspase 2, apoptosis-related cysteine peptidase
NCBI Gene ID 835
neXtProt AC  NX_P42575
Human Synonyms  CASP-2, ICH1, NEDD2, NEDD-2, PPP1R57
Human Chr (Location)  7q34-q35; chr7:143288215-143307696 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in abnormal apoptosis. Apoptosis is reduced in the female germline, but is increased in sympathetic neurons during development.
 
Interactions
Casp2 interacts with 277 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process apoptotic process, apoptotic signaling pathway, ...
Component cytoplasm, intracellular, ...
Function cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (118)    Tissues (57)    Images (3)
Theiler Stages: 4, 16, 18, 20, 21, 23, 25, 26, 28
Assay TypeResults
RT-PCR 113
RNase protection 5
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(5) cDNA(22) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023653 (Evidence)
Ensembl Gene ModelENSMUSG00000029863 (Evidence)
Entrez Gene12366 (Evidence)
DFCITC1571947, TC1736639
DoTSDT.533058, DT.99844528
NIA Mouse Gene IndexU006749
EC3.4.22.55
Consensus CDS ProjectCCDS20064.1
International Mouse Knockout Project StatusCasp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023653 VEGA Gene Model | MGI Sequence Detail 17524 C57BL/6J ±  kb
transcript OTTMUST00000057721 VEGA | MGI Sequence Detail 3529 Not Applicable 
polypeptide OTTMUSP00000027875 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(242 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017350 Caspase, interleukin-1 beta convertase
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR011600 Peptidase C14, caspase catalytic
InterPro IPR002138 Peptidase C14, caspase non-catalytic subunit p10
InterPro IPR015917 Peptidase C14, caspase precursor p45, core
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
InterPro IPR016129 Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology PR:000002311 caspase-2
References (Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:203049 Puccini J, et al., Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19920-5
All references(90)
Other
accession IDs
MGD-MRK-12808

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory