Casp2
Gene Detail

Symbol Name ID

Casp2 caspase 2 MGI:97295

Synonyms

Caspase-2, Ich-1, Nedd2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

20.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:42264985-42282508 bp, + strand From VEGA annotation of GRCm38   17524 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7254  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp2

Human homologs

Human Homolog		CASP2, caspase 2, apoptosis-related cysteine peptidase
NCBI Gene ID		835
neXtProt AC		NX_P42575
Human Synonyms		CASP-2, ICH1, NEDD2, NEDD-2, PPP1R57
Human Chr (Location)		7q34-q35; chr7:142985308-143004789 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(3) Gene trapped(3)
 

Homozygous mutation of this gene results in abnormal apoptosis. Apoptosis is reduced in the female germline, but is increased in sympathetic neurons during development.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	apoptotic process, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, ...
Component	cytoplasm, intracellular, ...
Function	cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (120)    Tissues (58)    Images (3)
Theiler Stages: 4, 16, 18, 20, 21, 23, 25, 26, 28

Assay Type	Results
RT-PCR	115
RNase protection	5

cDNA source data(111)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(123) Genomic(5) cDNA(113) Primer pair(4) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023653 (Evidence)
Ensembl Gene Model	ENSMUSG00000029863 (Evidence)
Entrez Gene	12366 (Evidence)
UniGene	3921
DFCI	TC1571947, TC1736639
DoTS	DT.533058, DT.99844528
NIA Mouse Gene Index	U006749
EC	3.4.22.55
Consensus CDS Project	CCDS20064.1
International Mouse Knockout Project Status	Casp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023653	VEGA Gene Model | MGI Sequence Detail	17524	C57BL/6J
transcript	OTTMUST00000057721	VEGA | MGI Sequence Detail	3529	Not Applicable
polypeptide	OTTMUSP00000027875	VEGA | MGI Sequence Detail	452	Not Applicable

All sequences(57) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(235 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017350	Caspase, interleukin-1 beta convertase
InterPro	IPR001315	Caspase Recruitment
InterPro	IPR011029	DEATH-like
InterPro	IPR011600	Peptidase C14, caspase catalytic
InterPro	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
InterPro	IPR002398	Peptidase C14, caspase precursor p45
InterPro	IPR015917	Peptidase C14, caspase precursor p45, core
InterPro	IPR001309	Peptidase C14, ICE, catalytic subunit p20
InterPro	IPR016129	Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology	PR:000002311	caspase-2

References

(Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:189071 Upton JP, et al., IRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 9;338(6108):818-22
All references(85)

Other accession IDs

MGD-MRK-12808