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Casp2
Gene Detail
Symbol

Name
ID
Casp2
caspase 2
MGI:97295
Synonyms
Caspase-2, Ich-1, Nedd2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
20.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:42264985-42282508 bp, + strand
From VEGA annotation of GRCm38

  17524 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7254  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CASP2
Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp2

Human
homologs
CASP2, caspase 2, apoptosis-related cysteine peptidase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 835
neXtProt AC: NX_P42575

Human Synonyms: CASP-2, ICH1, NEDD2, NEDD-2, PPP1R57

Human Chr (Location): 7q34-q35; chr7:143288215-143307696 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in abnormal apoptosis. Apoptosis is reduced in the female germline, but is increased in sympathetic neurons during development.
 
Interactions
Casp2 interacts with 277 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (17 records)
Data Summary: Results (118)    Tissues (58)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 113
RNase protection 5
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase casp2    NEW 
Molecular
reagents
All nucleic(32) Genomic(5) cDNA(22) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023653 (Evidence)
Ensembl Gene Model ENSMUSG00000029863 (Evidence)
Entrez Gene 12366 (Evidence)
DFCI TC1736639, TC1571947
DoTS DT.110478919, DT.99844528, DT.533058
NIA Mouse Gene Index U006749
EC 3.4.22.55
Consensus CDS Project CCDS20064.1
International Mouse Phenotyping Consortium Status Casp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023653 VEGA Gene Model | MGI Sequence Detail 17524 C57BL/6J ±  kb
transcript OTTMUST00000057721 VEGA | MGI Sequence Detail 3529 Not Applicable 
polypeptide OTTMUSP00000027875 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(242 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017350 Caspase, interleukin-1 beta convertase
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR011600 Peptidase C14, caspase catalytic
InterPro IPR002138 Peptidase C14, caspase non-catalytic subunit p10
InterPro IPR015917 Peptidase C14, caspase precursor p45, core
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
InterPro IPR016129 Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology PR:000002311 caspase-2
References
(Earliest) J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
(Latest) J:215039 Sharma R, et al., Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts. PLoS One. 2014;9(4):e93696
All references(90)
Other
accession IDs
MGD-MRK-12808

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory