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Casp2 Gene Detail
Summary
  • Symbol
    Casp2
  • Name
    caspase 2
  • Synonyms
    Caspase-2, Ich-1, Nedd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97295
    NCBI Gene: 12366
  • Gene Overview
    MyGene.info: CASP2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:42264985-42282508 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17524 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 20.54 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CASP2, caspase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CASP2, caspase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CASP-2, ICH1, NEDD2, NEDD-2, PPP1R57
  • Links
    NCBI Gene ID: 835
    neXtProt AC: NX_P42575
    UniProt: P42575

  • Chr Location
    7q34; chr7:143288215-143307696 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in abnormal apoptosis. Apoptosis is reduced in the female germline, but is increased in sympathetic neurons during development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023653 VEGA Gene Model | MGI Sequence Detail 17524 C57BL/6J ±  kb
    transcript OTTMUST00000057721 VEGA | MGI Sequence Detail 3529 Not Applicable  
    polypeptide OTTMUSP00000027875 VEGA | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      220 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 5
      cDNA 24
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12808
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 17
      Gene Ontology 12
      Phenotypes 32
    • Earliest
      J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
    • Latest
      J:241310 Dawar S, et al., Caspase-2-mediated cell death is required for deleting aneuploid cells. Oncogene. 2017 May 11;36(19):2704-2714

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory