About   Help   FAQ
Ndn
Gene Detail
Symbol

Name
ID
Ndn
necdin
MGI:97290
Synonyms
Peg6
Feature Type
protein coding gene
Genetic Map
Chromosome 7
34.36 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr7:62348277-62349928 bp, + strand
From NCBI annotation of GRCm38

  1652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: NDN
Protein SuperFamily: tumor associated protein MAGE
Gene Tree: Ndn

Human
homologs
NDN, necdin, melanoma antigen (MAGE) family member
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4692
neXtProt AC: NX_Q99608

Human Synonyms: HsT16328, PWCR

Human Chr (Location): 15q11.2-q12; chr15:23685407-23687303 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NDN

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(7) Transgenic(1)
Genomic Mutations involving Ndn (2)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit partial neonatal lethality, cyanosis and respiratory distress. Mice heterozygous for a knock-out allele exhibit abnormal behavior, abnormal nervous system morphology and physiology and, when inherited maternally, postnatal lethality with cyanosis.
 
Human Diseases Modeled in Mice Using Ndn (1)    Mutations Annotated to Human Diseases (6)    Phenotype Images(3)
Interactions
Ndn interacts with 135 markers (Mir23a, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process axonal fasciculation, axon extension, ...
Component cell projection, centrosome, ...
Function DNA binding, gamma-tubulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (51 records)
Data Summary: Results (301)    Tissues (215)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 173
In situ reporter (knock in) 26
Northern blot 49
Western blot 7
RT-PCR 31
cDNA source data(145)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(159) Genomic(5) cDNA(146) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000033585 (Evidence)
Entrez Gene 17984 (Evidence)
UniGene 400253
DFCI TC1571866, TC1675529
DoTS DT.535951, DT.94129733
NIA Mouse Gene Index U008170
Consensus CDS Project CCDS21326.1
International Mouse Phenotyping Consortium Status Ndn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17984 NCBI Gene Model | MGI Sequence Detail 1652 C57BL/6J ±  kb
transcript NM_010882 RefSeq | MGI Sequence Detail 1652 C57BL/6 
polypeptide P25233 UniProt | EBI | MGI Sequence Detail 325 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002190 MAGE protein
Protein Ontology PR:000011055 necdin
Graphical View of Protein Domain Structure
References
(Earliest) J:28227 Maruyama K, et al., A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells. Biochem Biophys Res Commun. 1991 Jul 15;178(1):291-6
(Latest) J:217174 Nakagaki A, et al., Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos. Gene. 2014 Dec 10;553(1):63-8
All references(114)
Disease annotation references (8)
Other
accession IDs
MGD-MRK-12799, MGI:2141993

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory