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Ndn
Gene Detail
 Symbol
Name
ID
Ndn
necdin
MGI:97290
Synonyms Peg6
Feature Type protein coding gene
Genetic Map
Chromosome 7
34.36 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr7:62348277-62349928 bp, + strand
From NCBI annotation of GRCm38

  1652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tumor associated protein MAGE
Gene Tree: Ndn

Human
homologs
Human Homolog NDN, necdin, melanoma antigen (MAGE) family member
NCBI Gene ID 4692
neXtProt AC  NX_Q99608
Human Synonyms  HsT16328, PWCR
Human Chr (Location)  15q11.2-q12; chr15:23685407-23687303 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NDN
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Mice homozygous for a knock-out allele exhibit partial neonatal lethality, cyanosis and respiratory distress. Mice heterozygous for a knock-out allele exhibit abnormal behavior, abnormal nervous system morphology and physiology and, when inherited maternally, postnatal lethality with cyanosis.
 
Human Diseases Modeled Using Mouse Ndn (1)    Alleles Annotated to Human Diseases(4)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process axonal fasciculation, axon extension, ...
Component cell projection, centrosome, ...
Function DNA binding, gamma-tubulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (46 records)
Data Summary: Results (301)    Tissues (211)    Images (64)
Theiler Stages: 15, 16, 17, 18, 19, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 15
RNA in situ 173
In situ reporter (knock in) 26
Northern blot 49
Western blot 7
RT-PCR 31
cDNA source data(145)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(159) Genomic(5) cDNA(146) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000033585 (Evidence)
Entrez Gene17984 (Evidence)
UniGene400253
DFCITC1571866, TC1675529
DoTSDT.535951, DT.94129733
NIA Mouse Gene IndexU008170
Consensus CDS ProjectCCDS21326.1
International Mouse Knockout Project StatusNdn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17984 NCBI Gene Model | MGI Sequence Detail 1652 C57BL/6J ±  kb
transcript NM_010882 RefSeq | MGI Sequence Detail 1652 C57BL/6 
polypeptide P25233 UniProt | EBI | MGI Sequence Detail 325 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002190 MAGE protein
Protein Ontology PR:000011055 necdin
Graphical View of Protein Domain Structure
References (Earliest) J:28227 Maruyama K, et al., A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells. Biochem Biophys Res Commun. 1991 Jul 15;178(1):291-6
(Latest) J:199643 Huang Z, et al., Necdin controls proliferation and apoptosis of embryonic neural stem cells in an oxygen tension-dependent manner. J Neurosci. 2013 Jun 19;33(25):10362-73
All references(109)
Other
accession IDs
MGD-MRK-12799, MGI:2141993

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory