Ndn
Gene Detail

Symbol Name ID

Ndn necdin MGI:97290

Synonyms

Peg6

Feature Type

protein coding gene

Genetic Map

Chromosome 7

34.36 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr7:62348277-62349928 bp, + strand From NCBI annotation of GRCm38   1652 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tumor associated protein MAGE
Gene Tree: Ndn

Human homologs

Human Homolog		NDN, necdin, melanoma antigen (MAGE) family member
NCBI Gene ID		4692
neXtProt AC		NX_Q99608
Human Synonyms		HsT16328, PWCR
Human Chr (Location)		15q11.2-q12; chr15:23930554-23932450 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NDN

Alleles and phenotypes

All alleles(6) : Targeted(6)
Human Diseases Modeled Using Mouse Ndn (1)    Alleles Annotated to Human Diseases(4)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	axonal fasciculation, axon extension, ...
Component	cell projection, centrosome, ...
Function	DNA binding, gamma-tubulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (42 records)
Data Summary: Results (300)    Tissues (211)    Images (63)
Theiler Stages: 15, 16, 17, 18, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	15
RNA in situ	172
In situ reporter (knock in)	26
Northern blot	49
Western blot	7
RT-PCR	31

cDNA source data(141)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(155) Genomic(5) cDNA(142) Primer pair(7) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000033585 (Evidence)
Entrez Gene	17984 (Evidence)
UniGene	400253
DFCI	TC1571866, TC1675529
DoTS	DT.535951, DT.94129733
NIA Mouse Gene Index	U008170
Consensus CDS Project	CCDS21326.1
International Mouse Knockout Project Status	Ndn

Sequences

Length	Strain/Species
genomic	17984	NCBI Gene Model | MGI Sequence Detail	1652	C57BL/6J
transcript	NM_010882	RefSeq | MGI Sequence Detail	1652	C57BL/6
polypeptide	P25233	UniProt | EBI | MGI Sequence Detail	325	Not Applicable

All sequences(33) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(16 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002190	MAGE protein
Protein Ontology	PR:000011055	necdin

Graphical View of Protein Domain Structure

References

(Earliest) J:28227 Maruyama K, et al., A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells. Biochem Biophys Res Commun. 1991 Jul 15;178(1):291-6
(Latest) J:189173 Asai T, et al., Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells. Blood. 2012 Aug 23;120(8):1601-12
All references(104)

Other accession IDs

MGD-MRK-12799, MGI:2141993