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Ncf2 Gene Detail
Summary
  • Symbol
    Ncf2
  • Name
    neutrophil cytosolic factor 2
  • Synonyms
    NADPH oxidase subunit (67kDa), Ncf-2, NOXA2, p67phox
  • Feature Type
    protein coding gene
  • IDs
    MGI:97284
    NCBI Gene: 17970
  • Gene Overview
    MyGene.info: NCF2
Location & Maps
more
  • Sequence Map
    Chr1:152800194-152836991 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      36798 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 65.05 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NCF2, neutrophil cytosolic factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NCF2, neutrophil cytosolic factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NCF-2, NOXA2, P67PHOX, P67-PHOX
  • Links
    NCBI Gene ID: 4688
    neXtProt AC: NX_P19878

  • Chr Location
    1q25; chr1:183555562-183590921 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 374
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NCF2
  • Gene Tree
    Ncf2
Human Diseases
more
  • Diseases
    1 with human NCF2 associations

Human Disease Mouse Models
       Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type II; CDG2   OMIM: 233710
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    2
  • Gene trapped
    10
  • Targeted
    3
  • Genomic Mutations
    2 involving Ncf2
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    26
  • Tissues
    17
  • cDNA Data
    36
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049696 VEGA Gene Model | MGI Sequence Detail 36798 C57BL/6J ±  kb
transcript OTTMUST00000126584 VEGA | MGI Sequence Detail 3550 Not Applicable  
polypeptide OTTMUSP00000068431 VEGA | MGI Sequence Detail 525 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    468 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    cDNA 37
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12790, MGD-MRK-12793
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:31031 Fasano O, et al., New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol. 1984 Sep;4(9):1695-705
  • Latest
    J:197839 Krishnaiah SY, et al., p67(phox) terminates the phospholipase A(2)-derived signal for activation of NADPH oxidase (NOX2). FASEB J. 2013 May;27(5):2066-73
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory