Ncf2 Gene Detail

Summary

• Symbol
  Ncf2
• Name
  neutrophil cytosolic factor 2
• Synonyms
  NADPH oxidase subunit (67kDa), Ncf-2, NOXA2, p67phox

• Feature Type
  protein coding gene
• IDs
  MGI:97284
  NCBI Gene: 17970
• Gene Overview
  MyGene.info: NCF2

Location & Maps

• Sequence Map
  Chr1:152800194-152836991 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    36798 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 65.05 cM
• Mapping Data
  4 experiments

Homology

• Human Ortholog
  NCF2, neutrophil cytosolic factor 2

• Vertebrate Orthologs
  9

• Human Ortholog
  NCF2, neutrophil cytosolic factor 2
  Orthology source: HomoloGene, HGNC
• Synonyms
  NCF-2, NOXA2, P67PHOX, P67-PHOX
• Links
  HGNC:7661

  NCBI Gene ID: 4688

  neXtProt AC: NX_P19878

  UniProt: P19878

  
  
• Chr Location
  1q25.3; chr1:183555562-183590921 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 374
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  
• HCOP
  human homology predictions: NCF2
• Gene Tree
  Ncf2
  

Human Diseases

• Diseases
  1 with human NCF2 associations

				Human Disease	Mouse Models
				chronic granulomatous disease IDs chronic granulomatous disease       DOID:3265 ICD10CM:D71 MESH:D006105 NCI:C26788 OMIM:138990 OMIM:233690 OMIM:233700 OMIM:233710 OMIM:306400 OMIM:613960 ORDO:379 UMLS_CUI:C0018203

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  15
• Chemically induced (other)
  2
• Gene trapped
  10
• Targeted
  3
• Genomic Mutations
  2 involving Ncf2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  23 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  26
• GO References
  7

• External Resources
  FuncBase

Expression

• Assay Results
  26
• Tissues
  17
• cDNA Data
  36
• Literature Summary
  5

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Ncf2 interacts with 115 markers (Mir18b, Mir19b-1, Mir19b-2, ...) View All

Sequences &
Gene Models

• All Sequences
  41
• RefSeq
  4
• UniProt
  4
• CCDS
  CCDS15367.1
• UniGene
  270307

• VEGA
  OTTMUSG00000049696 (Evidence)
• Ensembl
  ENSMUSG00000026480 (Evidence)
• NCBI Gene
  17970

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000049696	VEGA Gene Model | MGI Sequence Detail	36798	C57BL/6J
transcript	OTTMUST00000126584	VEGA | MGI Sequence Detail	3550	Not Applicable
polypeptide	OTTMUSP00000068431	VEGA | MGI Sequence Detail	525	Not Applicable

Polymorphisms

• SNPs within 2kb
  468 from dbSNP Build 142

• RFLP
  1

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000011031 neutrophil cytosol factor 2
  (term hierarchy)
• InterPro Domains
  IPR034889 Neutrophil cytosol factor 2
  IPR034885 Neutrophil cytosol factor 2, PB1 domain
  IPR035546 Neutrophil cytosol factor 2, SH3 domain 1
  IPR000270 PB1 domain
  IPR001452 SH3 domain
  IPR011990 Tetratricopeptide-like helical domain
  IPR019734 Tetratricopeptide repeat
  IPR001440 Tetratricopeptide repeat 1
  IPR013026 Tetratricopeptide repeat-containing domain

Molecular
Reagents

• All nucleic 38

  cDNA 37

  Primer pair 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-12790, MGD-MRK-12793

References

• Summaries
  All 43

  Developmental Gene Expression 5

  Gene Ontology 7

  Phenotypes 8
• Earliest
  J:31031 Fasano O, et al., New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol. 1984 Sep;4(9):1695-705
• Latest
  J:235644 Wu Y, et al., Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355