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Ncf2 Gene Detail
Summary
  • Symbol
    Ncf2
  • Name
    neutrophil cytosolic factor 2
  • Synonyms
    NADPH oxidase subunit (67kDa), Ncf-2, NOXA2, p67phox
  • Feature Type
    protein coding gene
  • IDs
    MGI:97284
    NCBI Gene: 17970
  • Gene Overview
    MyGene.info: NCF2
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:152800194-152836991 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 65.05 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    468 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97284
 protein coding gene Chr1:152800153-152836991 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016591
 protein coding gene Chr1:157575002-157616774 (+)
A/J MGP_AJ_G0016573
 protein coding gene Chr1:151226613-151264021 (+)
AKR/J MGP_AKRJ_G0016538
 protein coding gene Chr1:155891266-155940288 (+)
BALB/cJ MGP_BALBcJ_G0016533
 protein coding gene Chr1:151801018-151838075 (+)
C3H/HeJ MGP_C3HHeJ_G0016358
 protein coding gene Chr1:156013434-156042231 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016994
 protein coding gene Chr1:163024313-163061974 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014703
 protein coding gene Chr1:143543294-143582301 (+)
CAST/EiJ MGP_CASTEiJ_G0015937
 protein coding gene Chr1:155516422-155546604 (+)
CBA/J MGP_CBAJ_G0016332
 protein coding gene Chr1:168760174-168804791 (+)
DBA/2J MGP_DBA2J_G0016438
 protein coding gene Chr1:150241882-150278964 (+)
FVB/NJ MGP_FVBNJ_G0016436
 protein coding gene Chr1:148728963-148767623 (+)
LP/J MGP_LPJ_G0016509
 protein coding gene Chr1:158687540-158728967 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016462
 protein coding gene Chr1:176407644-176448207 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017030
 protein coding gene Chr1:155675723-155717955 (+)
PWK/PhJ MGP_PWKPhJ_G0015723
 protein coding gene Chr1:149256348-149296140 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015510
 protein coding gene Chr1:154484114-154523289 (+)
WSB/EiJ MGP_WSBEiJ_G0016000
 protein coding gene Chr1:155748184-155780829 (+)



Homology
more
  • Human Ortholog
    NCF2, neutrophil cytosolic factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NCF2, neutrophil cytosolic factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NCF-2, NOXA2, P67PHOX, P67-PHOX
  • Links
    NCBI Gene ID: 4688
    neXtProt AC: NX_P19878
    UniProt: P19878

  • Chr Location
    1q25.3; chr1:183555562-183590921 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 374
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NCF2
  • Gene Tree
    Ncf2
Human Diseases
more
  • Diseases
    1 with human NCF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele on a C57BL/6 background show increased susceptibility to A. fumigatus-induced pneumonia but do not develop systemic lupus. In contrast, homozygotes and even heterozygotes on a NZM 2328 background develop accelerated full-blown lupus with rapid lupus kidney disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    657
  • Tissues
    17
  • cDNA Data
    37
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026480 Ensembl Gene Model | MGI Sequence Detail 36798 C57BL/6J ±  kb
    transcript ENSMUST00000186568 Ensembl | MGI Sequence Detail 3550 Not Applicable  
    polypeptide ENSMUSP00000140404 Ensembl | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 38
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12790, MGD-MRK-12793
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:31031 Fasano O, et al., New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol. 1984 Sep;4(9):1695-705
    • Latest
      J:290456 Kong M, et al., Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription. Redox Biol. 2019 Sep;26:101302
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/12/2021
    MGI 6.16     		The Jackson Laboratory