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Ncf2
Gene Detail
 Symbol
Name
ID
Ncf2
neutrophil cytosolic factor 2
MGI:97284
Synonyms NADPH oxidase subunit (67kDa), Ncf-2, NOXA2, p67phox
Feature Type protein coding gene
Genetic Map
Chromosome 1
65.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:152807890-152836990 bp, + strand
From NCBI annotation of GRCm38

  29101 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:374  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ncf2

Human
homologs
Human Homolog NCF2, neutrophil cytosolic factor 2
NCBI Gene ID 4688
neXtProt AC  NX_P19878
Human Synonyms  NCF-2, NOXA2, P67PHOX, P67-PHOX
Human Chr (Location)  1q25; chr1:183555562-183590921 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NCF2
Alleles
and
phenotypes
All alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular response to hormone stimulus, NADP catabolic process, ...
Component acrosomal vesicle, cytoplasm, ...
Function protein binding, protein C-terminus binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (26)    Tissues (17)    Images (4)
Theiler Stages: 8, 10, 11, 12, 16, 17, 19, 22, 23, 24, 26
Assay TypeResults
Immunohistochemistry 6
RNA in situ 4
RT-PCR 16
cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(38) cDNA(37) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000026480 (Evidence)
Entrez Gene17970 (Evidence)
UniGene270307
DFCITC1572033, TC1649479
DoTSDT.101401728, DT.97373393
NIA Mouse Gene IndexU000922, U086961
Consensus CDS ProjectCCDS15367.1
International Mouse Knockout Project StatusNcf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17970 NCBI Gene Model | MGI Sequence Detail 29101 C57BL/6J ±  kb
transcript NM_010877 RefSeq | MGI Sequence Detail 2596 C57BL/6 
polypeptide O70145 UniProt | EBI | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(367 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000270 Phox/Bem1p
InterPro IPR001452 Src homology-3 domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000011031 neutrophil cytosol factor 2
Graphical View of Protein Domain Structure
References (Earliest) J:31031 Fasano O, et al., New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol. 1984 Sep;4(9):1695-705
(Latest) J:197839 Krishnaiah SY, et al., p67(phox) terminates the phospholipase A(2)-derived signal for activation of NADPH oxidase (NOX2). FASEB J. 2013 May;27(5):2066-73
All references(44)
Other
accession IDs
MGD-MRK-12790, MGD-MRK-12793

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory