Ncf2 MGI Mouse Gene Detail - MGI:97284 - neutrophil cytosolic factor 2

Ncf2 Gene Detail

Symbol

Ncf2
Name

neutrophil cytosolic factor 2
Synonyms

NADPH oxidase subunit (67kDa), Ncf-2, NOXA2, p67phox

Feature Type

protein coding gene
IDs

MGI:97284
NCBI Gene: 17970
Gene Overview

MyGene.info: NCF2
Alliance

gene page

Sequence Map

Chr1:152800194-152836991 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

36798 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.05 cM
Mapping Data

4 experiments

Human Ortholog

NCF2, neutrophil cytosolic factor 2

Vertebrate Orthologs

9

Human Ortholog

NCF2, neutrophil cytosolic factor 2
Orthology source: HomoloGene, HGNC
Synonyms

NCF-2, NOXA2, P67PHOX, P67-PHOX
Links

HGNC:7661

NCBI Gene ID: 4688

neXtProt AC: NX_P19878

UniProt: P19878
Chr Location

1q25.3; chr1:183555562-183590921 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 374
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: NCF2
Gene Tree

Ncf2

Diseases

1 with human NCF2 associations

				Human Disease	Mouse Models
				chronic granulomatous disease IDs chronic granulomatous disease DOID:3265 ICD10CM:D71 MESH:D006105 NCI:C26788 OMIM:138990 OMIM:233690 OMIM:233700 OMIM:233710 OMIM:306400 OMIM:613960 ORDO:379 UMLS_CUI:C0018203

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

16
Chemically induced (other)

2
Gene trapped

10
Targeted

4
Genomic Mutations

2 involving Ncf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

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All GO Annotations

26
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

26
Tissues

17
cDNA Data

36
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ncf2

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Ncf2 interacts with 115 markers (Mir18b, Mir19b-1, Mir19b-2, ...) View All

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All Sequences

41
RefSeq

4
UniProt

4
CCDS

CCDS15367.1
UniGene

270307

			Length	Strain/Species	Flank
genomic	OTTMUSG00000049696	VEGA Gene Model \| MGI Sequence Detail	36798	C57BL/6J	± kb
transcript	OTTMUST00000126584	VEGA \| MGI Sequence Detail	3550	Not Applicable
polypeptide	OTTMUSP00000068431	VEGA \| MGI Sequence Detail	525	Not Applicable

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SNPs within 2kb

468 from dbSNP Build 142

RFLP

1

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UniProt

4 Sequences
Protein Ontology

PR:000011031 neutrophil cytosol factor 2

(term hierarchy)
InterPro Domains

IPR034889 Neutrophil cytosol factor 2

IPR034885 Neutrophil cytosol factor 2, PB1 domain

IPR035546 Neutrophil cytosol factor 2, SH3 domain 1

IPR000270 PB1 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

IPR001440 Tetratricopeptide repeat 1

IPR013026 Tetratricopeptide repeat-containing domain

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All nucleic 38

cDNA 37

Primer pair 1

Microarray probesets 4

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MGD-MRK-12790, MGD-MRK-12793

Summaries

All 49

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 9
Earliest

J:31031 Fasano O, et al., New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol. 1984 Sep;4(9):1695-705
Latest

J:235644 Wu Y, et al., Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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