Ncf2
Gene Detail

Symbol

Name
ID

Ncf2
neutrophil cytosolic factor 2
MGI:97284

Synonyms

NADPH oxidase subunit (67kDa), Ncf-2, NOXA2, p67phox

Feature Type

protein coding gene

Genetic Map

Chromosome 1
65.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:152800194-152836991 bp, + strand From VEGA annotation of GRCm38   36798 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:374  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ncf2

Human
homologs

Human Homolog		NCF2, neutrophil cytosolic factor 2
NCBI Gene ID		4688
neXtProt AC		NX_P19878
Human Synonyms		NCF-2, NOXA2, P67PHOX, P67-PHOX
Human Chr (Location)		1q25; chr1:183555562-183590921 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human NCF2

Mutations,
alleles, and
phenotypes

All mutations/alleles(13) : Gene trapped(10) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Ncf2 interacts with 116 markers (Mir18b, Mir19b-1, Mir19b-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (22 annotations)

Process	cellular response to hormone stimulus, NADP catabolic process, ...
Component	acrosomal vesicle, cytoplasm, ...
Function	protein binding, protein C-terminus binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (26)    Tissues (17)    Images (4)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	6
RNA in situ	4
RT-PCR	16

cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(38) cDNA(37) Primer pair(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000049696 (Evidence)
Ensembl Gene Model	ENSMUSG00000026480 (Evidence)
Entrez Gene	17970 (Evidence)
UniGene	270307
DFCI	TC1572033, TC1649479
DoTS	DT.101401728, DT.97373393
NIA Mouse Gene Index	U000922, U086961
Consensus CDS Project	CCDS15367.1
International Mouse Knockout Project Status	Ncf2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000049696	VEGA Gene Model | MGI Sequence Detail	36798	C57BL/6J
transcript	OTTMUST00000126584	VEGA | MGI Sequence Detail	3550	Not Applicable
polypeptide	OTTMUSP00000068431	VEGA | MGI Sequence Detail	525	Not Applicable

All sequences(52) RefSeq(8) UniProt(6)

Polymorphisms

RFLP(1) : SNPs within 2kb(468 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000270	Phox/Bem1p
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR019734	Tetratricopeptide repeat
InterPro	IPR013026	Tetratricopeptide repeat-containing domain
InterPro	IPR001440	Tetratricopeptide TPR-1
Protein Ontology	PR:000011031	neutrophil cytosol factor 2

References

(Earliest) J:31031 Fasano O, et al., New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol. 1984 Sep;4(9):1695-705
(Latest) J:197839 Krishnaiah SY, et al., p67(phox) terminates the phospholipase A(2)-derived signal for activation of NADPH oxidase (NOX2). FASEB J. 2013 May;27(5):2066-73
All references(45)

Other
accession IDs

MGD-MRK-12790, MGD-MRK-12793