Ncf2 MGI Mouse Gene Detail - MGI:97284 - neutrophil cytosolic factor 2

Symbol

Ncf2
Name

neutrophil cytosolic factor 2
Synonyms

NADPH oxidase subunit (67kDa), Ncf-2, NOXA2, p67phox

Feature Type

protein coding gene
IDs

MGI:97284
NCBI Gene: 17970
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr1:152675945-152712742 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.05 cM
Mapping Data

4 experiments

SNPs within 2kb

1400 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97284	protein coding gene	Chr1:152675904-152712743 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016591	protein coding gene	Chr1:157575002-157616774 (+)
A/J	MGP_AJ_G0016573	protein coding gene	Chr1:151226613-151264021 (+)
AKR/J	MGP_AKRJ_G0016538	protein coding gene	Chr1:155891266-155940288 (+)
BALB/cJ	MGP_BALBcJ_G0016533	protein coding gene	Chr1:151801018-151838075 (+)
C3H/HeJ	MGP_C3HHeJ_G0016358	protein coding gene	Chr1:156013434-156042231 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016994	protein coding gene	Chr1:163024313-163061974 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014703	protein coding gene	Chr1:143543294-143582301 (+)
CAST/EiJ	MGP_CASTEiJ_G0015937	protein coding gene	Chr1:155516422-155546604 (+)
CBA/J	MGP_CBAJ_G0016332	protein coding gene	Chr1:168760174-168804791 (+)
DBA/2J	MGP_DBA2J_G0016438	protein coding gene	Chr1:150241882-150278964 (+)
FVB/NJ	MGP_FVBNJ_G0016436	protein coding gene	Chr1:148728963-148767623 (+)
LP/J	MGP_LPJ_G0016509	protein coding gene	Chr1:158687540-158728967 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016462	protein coding gene	Chr1:176407644-176448207 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017030	protein coding gene	Chr1:155675723-155717955 (+)
PWK/PhJ	MGP_PWKPhJ_G0015723	protein coding gene	Chr1:149256348-149296140 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015510	protein coding gene	Chr1:154484114-154523289 (+)
WSB/EiJ	MGP_WSBEiJ_G0016000	protein coding gene	Chr1:155748184-155780829 (+)

Human Ortholog

NCF2, neutrophil cytosolic factor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCF2, neutrophil cytosolic factor 2
Synonyms

NCF-2, NOXA2, P67-PHOX, P67PHOX
Links

HGNC:7661

NCBI Gene ID: 4688

UniProt: P19878
Chr Location

1q25.3; chr1:183554461-183601849 (-) GRCh38

MGI Vertebrate Homology

Ncf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NCF2
Gene Tree

Ncf2

Diseases

3 with human NCF2 associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				autosomal recessive chronic granulomatous disease 2 IDs autosomal recessive chronic granulomatous disease 2 DOID:0070191 OMIM:233710
				rheumatoid arthritis IDs rheumatoid arthritis DOID:7148 EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C2884 OMIM:180300 UMLS_CUI:C0003873

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

34 phenotypes from 2 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

3
Targeted

6
Genomic Mutations

2 involving Ncf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele on a C57BL/6 background show increased susceptibility to A. fumigatus-induced pneumonia but do not develop systemic lupus. In contrast, homozygotes and even heterozygotes on a NZM 2328 background develop accelerated full-blown lupus with rapid lupus kidney disease.

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All GO Annotations

41
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

17
cDNA Data

37
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ncf2

ZFIN ncf2

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All Sequences

57
RefSeq

10
UniProt

4
CCDS

CCDS15367.1

Ensembl

ENSMUSG00000026480 (Evidence)
NCBI Gene

17970

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026480	Ensembl Gene Model \| MGI Sequence Detail	36798	C57BL/6J	± kb
transcript	ENSMUST00000186568	Ensembl \| MGI Sequence Detail	3550	Not Applicable
polypeptide	ENSMUSP00000140404	Ensembl \| MGI Sequence Detail	525	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011031 neutrophil cytosol factor 2

(term hierarchy)
InterPro Domains

IPR051864 NADPH Oxidase Activator

IPR034885 Neutrophil cytosol factor 2, PB1 domain

IPR034889 Neutrophil cytosol factor 2, SH3 domain

IPR035546 Neutrophil cytosol factor 2, SH3 domain 1

IPR000270 PB1 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

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All nucleic 39

cDNA 38

Primer pair 1

Microarray probesets 4

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MGD-MRK-12790, MGD-MRK-12793

Summaries

All 68

Developmental Gene Expression 6

Gene Ontology 12

Phenotypes 19
Earliest

J:31031 Fasano O, et al., New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol. 1984 Sep;4(9):1695-705
Latest

J:345820 Cardarelli S, et al., Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress. Cell Death Dis. 2024 Feb 23;15(2):169

TSS for Ncf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9423	Chr1:152683523-152683541 (+)	7,587 bp
Tssr9424	Chr1:152683570-152683577 (+)	7,629 bp
Tssr9425	Chr1:152683578-152683627 (+)	7,658 bp
Tssr9426	Chr1:152683628-152683649 (+)	7,694 bp
Tssr9427	Chr1:152683656-152683667 (+)	7,717 bp
Tssr9428	Chr1:152683669-152683685 (+)	7,732 bp
Tssr9429	Chr1:152683699-152683710 (+)	7,760 bp
Tssr9430	Chr1:152685858-152685871 (+)	9,920 bp
Tssr9431	Chr1:152687167-152687192 (+)	11,235 bp
Tssr9432	Chr1:152687362-152687382 (+)	11,427 bp
Tssr9433	Chr1:152688224-152688243 (+)	12,289 bp
Tssr9434	Chr1:152688256-152688268 (+)	12,317 bp
Tssr9435	Chr1:152693192-152693196 (+)	17,249 bp
Tssr9436	Chr1:152700504-152700509 (+)	24,562 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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