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Ncf2
Gene Detail
Symbol

Name
ID
Ncf2
neutrophil cytosolic factor 2
MGI:97284
Synonyms
NADPH oxidase subunit (67kDa), Ncf-2, NOXA2, p67phox
Feature Type
protein coding gene
Genetic Map
Chromosome 1
65.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:152800194-152836991 bp, + strand
From VEGA annotation of GRCm38

  36798 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:374  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NCF2
Gene Tree: Ncf2

Human
homologs
NCF2, neutrophil cytosolic factor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4688
neXtProt AC: NX_P19878

Human Synonyms: NCF-2, NOXA2, P67PHOX, P67-PHOX

Human Chr (Location): 1q25; chr1:183555562-183590921 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NCF2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(10) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ncf2 interacts with 115 markers (Mir18b, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular response to hormone stimulus, NADP catabolic process, ...
Component acrosomal vesicle, cytoplasm, ...
Function protein binding, protein C-terminus binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (26)    Tissues (17)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 4
RT-PCR 16
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ncf2    NEW 
Molecular
reagents
All nucleic(38) cDNA(37) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000049696 (Evidence)
Ensembl Gene Model ENSMUSG00000026480 (Evidence)
Entrez Gene 17970 (Evidence)
UniGene 270307
DFCI TC1572033, TC1649479
DoTS DT.101401728, DT.97373393
NIA Mouse Gene Index U000922, U086961
Consensus CDS Project CCDS15367.1
International Mouse Phenotyping Consortium Status Ncf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049696 VEGA Gene Model | MGI Sequence Detail 36798 C57BL/6J ±  kb
transcript OTTMUST00000126584 VEGA | MGI Sequence Detail 3550 Not Applicable 
polypeptide OTTMUSP00000068431 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(468 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000270 PB1 domain
InterPro IPR001452 SH3 domain
InterPro IPR011990 Tetratricopeptide-like helical domain
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR001440 Tetratricopeptide repeat 1
InterPro IPR013026 Tetratricopeptide repeat-containing domain
Protein Ontology PR:000011031 neutrophil cytosol factor 2
References
(Earliest) J:31031 Fasano O, et al., New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol. 1984 Sep;4(9):1695-705
(Latest) J:197839 Krishnaiah SY, et al., p67(phox) terminates the phospholipase A(2)-derived signal for activation of NADPH oxidase (NOX2). FASEB J. 2013 May;27(5):2066-73
All references(42)
Other
accession IDs
MGD-MRK-12790, MGD-MRK-12793

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory