Ncam2 MGI Mouse Gene Detail - MGI:97282 - neural cell adhesion molecule 2

Symbol

Ncam2
Name

neural cell adhesion molecule 2
Synonyms

Ncam-2, Ocam, R4B12 antigen, RNCAM

Feature Type

protein coding gene
IDs

MGI:97282
NCBI Gene: 17968
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr16:80997585-81423716 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 45.89 cM, cytoband C1-3
Mapping Data

4 experiments

SNPs within 2kb

24468 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97282	protein coding gene	Chr16:80997501-81425549 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022966	protein coding gene	Chr16:81562421-82057882 (+)
A/J	MGP_AJ_G0022934	protein coding gene	Chr16:77892856-78321252 (+)
AKR/J	MGP_AKRJ_G0022904	protein coding gene	Chr16:80197328-80639546 (+)
BALB/cJ	MGP_BALBcJ_G0022936	protein coding gene	Chr16:78287993-78731772 (+)
C3H/HeJ	MGP_C3HHeJ_G0022698	protein coding gene	Chr16:80693289-81152137 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023383	protein coding gene	Chr16:84197744-84678312 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020887	protein coding gene	Chr16:76126254-76552479 (+)
CAST/EiJ	MGP_CASTEiJ_G0022220	protein coding gene	Chr16:81179384-81642934 (+)
CBA/J	MGP_CBAJ_G0022667	protein coding gene	Chr16:87749140-88255435 (+)
DBA/2J	MGP_DBA2J_G0022801	protein coding gene	Chr16:77735846-78179022 (+)
FVB/NJ	MGP_FVBNJ_G0022776	protein coding gene	Chr16:77022051-77447065 (+)
LP/J	MGP_LPJ_G0022870	protein coding gene	Chr16:81258365-81714097 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022795	protein coding gene	Chr16:91387722-91999079 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023401	protein coding gene	Chr16:80568949-81038777 (+)
PWK/PhJ	MGP_PWKPhJ_G0021962	protein coding gene	Chr16:77926354-78369317 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021792	protein coding gene	Chr16:80187324-80664072 (+)
WSB/EiJ	MGP_WSBEiJ_G0022268	protein coding gene	Chr16:80806378-81273686 (+)

Human Ortholog

NCAM2, neural cell adhesion molecule 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCAM2, neural cell adhesion molecule 2
Synonyms

NCAM21
Links

HGNC:7657

NCBI Gene ID: 4685

UniProt: O15394
Chr Location

21q21.1; chr21:20998409-21543329 (+) GRCh38

MGI Vertebrate Homology

Ncam2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NCAM2
Gene Tree

Ncam2

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References

7 with disease annotations

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
383 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Endonuclease-mediated

3
Gene trapped

5
Radiation induced

1
Targeted

13
Transgenic

2
Genomic Mutations

7 involving Ncam2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

A gene trap insertion into an intron of this gene results in no obvious phenotype. Mice homozygous for a knock-out allele exhibit exhibit increased proliferation rate and clonogenic frequency in spinal cord-derived neurospheres.

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All GO Annotations

19
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1010
Tissues

158
cDNA Data

23
Literature Summary

32

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ncam2

ZFIN ncam2

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All Sequences

48
RefSeq

8
UniProt

3
CCDS

CCDS28281.1, CCDS49888.1

Ensembl

ENSMUSG00000022762 (Evidence)
NCBI Gene

17968

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022762	Ensembl Gene Model \| MGI Sequence Detail	426132	C57BL/6J	± kb
transcript	ENSMUST00000067602	Ensembl \| MGI Sequence Detail	6106	Not Applicable
polypeptide	ENSMUSP00000063468	Ensembl \| MGI Sequence Detail	837	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011018 neural cell adhesion molecule 2

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

IPR051170 Neural and epithelial cell adhesion domain-containing protein

IPR009138 Neural cell adhesion
GlyGen

O35136 10 sites, 16 N-linked glycans (7 sites), 1 O-linked glycan (1 site)

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All nucleic 30

Genomic 1

cDNA 23

Primer pair 3

Other 3

Microarray probesets 6

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MGD-MRK-12787, MGD-MRK-12788, MGI:1095738

Summaries

All 447

Developmental Gene Expression 32

Diseases 7

Gene Ontology 9

Phenotypes 383
Earliest

J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
Latest

J:366667 Sherman KM, et al., Male Down syndrome Ts65Dn mice have impaired bone regeneration. Bone. 2025 Mar;192:117374

TSS for Ncam2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139132	Chr16:80997552-80997568 (+)	-25 bp
Tssr139133	Chr16:80997596-80997605 (+)	16 bp
Tssr139134	Chr16:80997613-80997627 (+)	35 bp
Tssr139135	Chr16:80997635-80997654 (+)	60 bp
Tssr139136	Chr16:80998161-80998165 (+)	578 bp
Tssr139137	Chr16:81000261-81000264 (+)	2,678 bp
Tssr139138	Chr16:81034621-81034632 (+)	37,042 bp
Tssr139139	Chr16:81035594-81035599 (+)	38,012 bp
Tssr139140	Chr16:81066593-81066602 (+)	69,013 bp
Tssr139141	Chr16:81082233-81082238 (+)	84,651 bp
Tssr139142	Chr16:81420646-81420650 (+)	423,063 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24