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Ncam2 Gene Detail
Summary
  • Symbol
    Ncam2
  • Name
    neural cell adhesion molecule 2
  • Synonyms
    Ncam-2, Ocam, R4B12 antigen, RNCAM
  • Feature Type
    protein coding gene
  • IDs
    MGI:97282
    NCBI Gene: 17968
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr16:81200697-81624285 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      423589 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 45.89 cM, cytoband C1-3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NCAM2, neural cell adhesion molecule 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NCAM2, neural cell adhesion molecule 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NCAM21
  • Links
    NCBI Gene ID: 4685
    neXtProt AC: NX_O15394
    UniProt: O15394

  • Chr Location
    21q21.1; chr21:20998315-21543324 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A gene trap insertion into an intron of this gene results in no obvious phenotype. Mice homozygous for a knock-out allele exhibit exhibit increased proliferation rate and clonogenic frequency in spinal cord-derived neurospheres.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    212
  • Tissues
    133
  • cDNA Data
    21
  • Literature Summary
    26
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014960 VEGA Gene Model | MGI Sequence Detail 423589 C57BL/6J ±  kb
transcript OTTMUST00000035517 VEGA | MGI Sequence Detail 3563 Not Applicable  
polypeptide OTTMUSP00000015902 VEGA | MGI Sequence Detail 837 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1150 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 1
    cDNA 21
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-12787, MGD-MRK-12788, MGI:1095738
References
more
  • Summaries
    All 74
    Developmental Gene Expression 26
    Diseases 1
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:41769 Yoshihara Y, et al., OCAM: A new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons. J Neurosci. 1997 Aug 1;17(15):5830-42
  • Latest
    J:242664 Gupta M, et al., Mouse models of Down syndrome: gene content and consequences. Mamm Genome. 2016 Dec;27(11-12):538-555
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory