Ncam2 MGI Mouse Gene Detail - MGI:97282 - neural cell adhesion molecule 2

Ncam2 Gene Detail

Symbol

Ncam2
Name

neural cell adhesion molecule 2
Synonyms

Ncam-2, Ocam, R4B12 antigen, RNCAM

Feature Type

protein coding gene
IDs

MGI:97282
NCBI Gene: 17968

Sequence Map

Chr16:81200697-81624285 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

423589 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 45.89 cM, cytoband C1-3
Mapping Data

4 experiments

Human Ortholog

NCAM2, neural cell adhesion molecule 2

Vertebrate Orthologs

11

Human Ortholog

NCAM2, neural cell adhesion molecule 2
Orthology source: HomoloGene, HGNC
Synonyms

NCAM21
Links

HGNC:7657

NCBI Gene ID: 4685

neXtProt AC: NX_O15394

UniProt: O15394
Chr Location

21q21.1; chr21:20998315-21543324 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3336
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NCAM2
Protein SuperFamily

cell adhesion molecule, NCAM/Fasciclin-2 types
Gene Tree

Ncam2

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Gene trapped

8
Targeted

11
Genomic Mutations

4 involving Ncam2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available

A gene trap insertion into an intron of this gene results in no obvious phenotype. Mice homozygous for a knock-out allele exhibit exhibit increased proliferation rate and clonogenic frequency in spinal cord-derived neurospheres.

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All GO Annotations

9
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

212
Tissues

133
cDNA Data

21
Literature Summary

24

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ncam2

ZFIN ncam2

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Ncam2 interacts with 303 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

29
RefSeq

4
UniProt

3
CCDS

CCDS28281.1, CCDS49888.1
UniGene

433941

			Length	Strain/Species	Flank
genomic	OTTMUSG00000014960	VEGA Gene Model \| MGI Sequence Detail	423589	C57BL/6J	± kb
transcript	OTTMUST00000035517	VEGA \| MGI Sequence Detail	3563	Not Applicable
polypeptide	OTTMUSP00000015902	VEGA \| MGI Sequence Detail	837	Not Applicable

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SNPs within 2kb

1150 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000011018 neural cell adhesion molecule 2

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

IPR009138 Neural cell adhesion

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All nucleic 25

Genomic 1

cDNA 21

Primer pair 3

Microarray probesets 6

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MGD-MRK-12787, MGD-MRK-12788, MGI:1095738

Summaries

All 64

Developmental Gene Expression 24

Diseases 1

Gene Ontology 4

Phenotypes 17
Earliest

J:41769 Yoshihara Y, et al., OCAM: A new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons. J Neurosci. 1997 Aug 1;17(15):5830-42
Latest

J:227899 Lana-Elola E, et al., Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 2016 Jan 14;5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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