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Ncam1
Gene Detail
 Symbol
Name
ID
Ncam1
neural cell adhesion molecule 1
MGI:97281
STS D9Mit22, D9Mit26, D9Mit94, D9Mit98, D9Nds6
Synonyms CD56, E-NCAM, NCAM, NCAM-1, NCAM-120, NCAM-140, NCAM-180
Feature Type protein coding gene
Genetic Map
Chromosome 9
26.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr9:49504361-49798922 bp, - strand
From Ensembl annotation of GRCm38

  294562 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40754  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cell adhesion molecule, NCAM/Fasciclin-2 types
Gene Tree: Ncam1

Human
homologs
Human Homolog NCAM1, neural cell adhesion molecule 1
NCBI Gene ID 4684
neXtProt AC  NX_P13591
Human Synonyms  CD56, MSK39, NCAM
Human Chr (Location)  11q23.1; chr11:112961247-113278436 (+)  GRCh38
Alleles
and
phenotypes
All alleles(21) : Gene trapped(10) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants show impairment in Morris water maze test, reduced brain and olfactory bulb size, hypoplasic corticospinal tract, abnormally distributed anterior pituitary cell types, and morphological and functional defects of neuromuscular junctions.
 
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process aging, cell adhesion, ...
Component anchored component of membrane, axon, ...
Function heparin binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (245 records)
Data Summary: Results (784)    Tissues (229)    Images (228)
Theiler Stages: 2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 285
RNA in situ 342
Northern blot 1
Western blot 80
RT-PCR 73
Nuclease S1 3
cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(85) Genomic(28) cDNA(46) Primer pair(9) Other(2)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000039542 (Evidence)
Entrez Gene17967 (Evidence)
DFCITC1579658, TC1591322, TC1598634, TC1605247, TC1625601, TC1640840, TC1644052
NIA Mouse Gene IndexU030833
PDB2NCM, 3NCM
Consensus CDS ProjectCCDS40617.1, CCDS40618.1
International Mouse Knockout Project StatusNcam1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039542 Ensembl Gene Model | MGI Sequence Detail 294562 C57BL/6J ±  kb
transcript ENSMUST00000166811 Ensembl | MGI Sequence Detail 3629 Not Applicable 
polypeptide ENSMUSP00000130668 Ensembl | MGI Sequence Detail 848 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(50) UniProt(8)
Polymorphisms All PCR and RFLP(9) : PCR(5) RFLP(4) SNPs within 2kb(1903 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR009138 Neural cell adhesion
Protein Ontology PR:000001024 neural cell adhesion molecule 1
References (Earliest) J:37744 Rougon G, et al., Tissue- and developmental stage-specific forms of a neural cell surface antigen linked to differences in glycosylation of a common polypeptide. EMBO J. 1982;1(10):1239-44
(Latest) J:204686 Shetty A, et al., The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent mechanisms. J Neurosci. 2013 Oct 16;33(42):16828-45
All references(437)
Other
accession IDs
MGD-MRK-12786

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory