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Ncam1
Gene Detail
Symbol

Name
ID
Ncam1
neural cell adhesion molecule 1
MGI:97281
Synonyms
CD56, E-NCAM, NCAM, NCAM-1, NCAM-120, NCAM-140, NCAM-180
Feature Type
protein coding gene
Genetic Map
Chromosome 9
26.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr9:49502136-49798925 bp, - strand
From VEGA annotation of GRCm38

  296790 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40754  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cell adhesion molecule, NCAM/Fasciclin-2 types
Gene Tree: Ncam1

Human
homologs
Human Homolog   NCAM1, neural cell adhesion molecule 1
NCBI Gene ID 4684
neXtProt AC  NX_P13591
Human Synonyms  CD56, MSK39, NCAM
Human Chr (Location)  11q23.1; chr11:112961247-113278436 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(10) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants show impairment in Morris water maze test, reduced brain and olfactory bulb size, hypoplasic corticospinal tract, abnormally distributed anterior pituitary cell types, and morphological and functional defects of neuromuscular junctions.
 
Interactions
Ncam1 interacts with 254 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process aging, cell adhesion, ...
Component anchored component of membrane, axon, ...
Function heparin binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (257 records)
Data Summary: Results (782)    Tissues (258)    Images (228)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 309
RNA in situ 342
Northern blot 5
Western blot 50
RT-PCR 73
Nuclease S1 3
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(85) Genomic(28) cDNA(46) Primer pair(9) Other(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000052150 (Evidence)
Ensembl Gene ModelENSMUSG00000039542 (Evidence)
Entrez Gene17967 (Evidence)
DFCITC1579658, TC1591322, TC1598634, TC1605247, TC1625601, TC1640840, TC1644052
NIA Mouse Gene IndexU030833
PDB2NCM, 3NCM
Consensus CDS ProjectCCDS40617.1, CCDS40618.1
International Mouse Knockout Project StatusNcam1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052150 VEGA Gene Model | MGI Sequence Detail 296790 C57BL/6J ±  kb
transcript OTTMUST00000131052 VEGA | MGI Sequence Detail 6564 Not Applicable 
polypeptide OTTMUSP00000070135 VEGA | MGI Sequence Detail 1089 Not Applicable 

For the selected sequences
All sequences(133) RefSeq(56) UniProt(12)
Polymorphisms
All PCR and RFLP(9) : PCR(5) RFLP(4) SNPs within 2kb(1907 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR009138 Neural cell adhesion
Protein Ontology PR:000001024 neural cell adhesion molecule 1
References
(Earliest) J:37744 Rougon G, et al., Tissue- and developmental stage-specific forms of a neural cell surface antigen linked to differences in glycosylation of a common polypeptide. EMBO J. 1982;1(10):1239-44
(Latest) J:217534 Markenscoff-Papadimitriou E, et al., Enhancer interaction networks as a means for singular olfactory receptor expression. Cell. 2014 Oct 23;159(3):543-57
All references(452)
Other
accession IDs
MGD-MRK-12786

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory