Ncam1
Gene Detail

Symbol Name ID

Ncam1 neural cell adhesion molecule 1 MGI:97281

STS

D9Mit22, D9Mit26, D9Mit94, D9Mit98, D9Nds6

Synonyms

CD56, E-NCAM, NCAM, NCAM-1, NCAM-120, NCAM-140, NCAM-180

Feature Type

protein coding gene

Genetic Map

Chromosome 9

26.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)

Sequence Map

Chr9:49504361-49798922 bp, - strand From Ensembl annotation of GRCm38   294562 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40754  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cell adhesion molecule, NCAM/Fasciclin-2 types
Gene Tree: Ncam1

Human homologs

Human Homolog		NCAM1, neural cell adhesion molecule 1
NCBI Gene ID		4684
neXtProt AC		NX_P13591
Human Synonyms		CD56, MSK39, NCAM
Human Chr (Location)		11q23.1; chr11:112831969-113149158 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(21) : Targeted(11) Gene trapped(10)
 

Homozygous mutants show impairment in Morris water maze test, reduced brain and olfactory bulb size, hypoplasic corticospinal tract, abnormally distributed anterior pituitary cell types, and morphological and functional defects of neuromuscular junctions.

 

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	aging, cell adhesion, ...
Component	anchored to membrane, axon, ...
Function	heparin binding, LRR domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (232 records)
Data Summary: Results (693)    Tissues (215)    Images (165)
Theiler Stages: 2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	199
RNA in situ	342
Northern blot	1
Western blot	75
RT-PCR	73
Nuclease S1	3

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(85) Genomic(28) cDNA(46) Primer pair(9) Other(2)
Microarray probesets(9)

Other database links

Ensembl Gene Model	ENSMUSG00000039542 (Evidence)
Entrez Gene	17967 (Evidence)
DFCI	TC1579658, TC1591322, TC1598634, TC1605247, TC1625601, TC1640840, TC1644052
NIA Mouse Gene Index	U030833
PDB	2NCM, 3NCM
Consensus CDS Project	CCDS40617.1, CCDS40618.1
International Mouse Knockout Project Status	Ncam1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000039542	Ensembl Gene Model | MGI Sequence Detail	294562	C57BL/6J
transcript	ENSMUST00000166811	Ensembl | MGI Sequence Detail	3629	Not Applicable
polypeptide	ENSMUSP00000130668	Ensembl | MGI Sequence Detail	848	Not Applicable

All sequences(58) RefSeq(6) UniProt(8)

Polymorphisms

All PCR and RFLP(9) : PCR(5) RFLP(4) SNPs(1691 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR009138	Neural cell adhesion
Protein Ontology	PR:000001024	neural cell adhesion molecule 1

References

(Earliest) J:37744 Rougon G, et al., Tissue- and developmental stage-specific forms of a neural cell surface antigen linked to differences in glycosylation of a common polypeptide. EMBO J. 1982;1(10):1239-44
(Latest) J:193907 Li S, et al., The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1). J Neurosci. 2013 Jan 9;33(2):790-803
All references(418)

Other accession IDs

MGD-MRK-12786