About   Help   FAQ
Myog
Gene Detail
Symbol

Name
ID
Myog
myogenin
MGI:97276
Synonyms
bHLHc3, myo
Feature Type
protein coding gene
Genetic Map
Chromosome 1
58.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr1:134289989-134292548 bp, + strand
From VEGA annotation of GRCm38

  2560 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1854  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYOG
Protein SuperFamily: human myogenin
Gene Tree: Myog

Human
homologs
MYOG, myogenin (myogenic factor 4)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4656
neXtProt AC: NX_P15173

Human Synonyms: bHLHc3, myf-4, MYF4

Human Chr (Location): 1q31-q41; chr1:203083129-203086038 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit a severe reduction in muscle mass associated with delayed primary myogenesis and very little secondary myofiber formation, defects of the thoracic skeleton, and perinatal death.
 
Interactions
Myog interacts with 62 markers (Mir7-1, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process cell cycle, cell differentiation, ...
Component nucleus, protein-DNA complex
Function chromatin DNA binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (291 records)
Data Summary: Results (681)    Tissues (287)    Images (231)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 56
RNA in situ 477
Northern blot 12
Western blot 9
RT-PCR 127
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MYOG ; Xenbase myog ; ZFIN myog    NEW 
Molecular
reagents
All nucleic(108) Genomic(5) cDNA(64) Primer pair(16) Other(23)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000049677 (Evidence)
Ensembl Gene Model ENSMUSG00000026459 (Evidence)
Entrez Gene 17928 (Evidence)
UniGene 16528
DFCI TC1581588
DoTS DT.534075
NIA Mouse Gene Index U000825
Consensus CDS Project CCDS15306.1
International Mouse Phenotyping Consortium Status Myog
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049677 VEGA Gene Model | MGI Sequence Detail 2560 C57BL/6J ±  kb
transcript OTTMUST00000126546 VEGA | MGI Sequence Detail 1495 Not Applicable 
polypeptide OTTMUSP00000068414 VEGA | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR002546 Myogenic basic muscle-specific protein
Protein Ontology PR:000010877 myogenin
References
(Earliest) J:9615 Wright WE, et al., Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD. Cell. 1989 Feb 24;56(4):607-17
(Latest) J:220963 Nosavanh L, et al., Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5069-74
All references(385)
Other
accession IDs
MGD-MRK-12775

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory