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Myog Gene Detail
Summary
  • Symbol
    Myog
  • Name
    myogenin
  • Synonyms
    bHLHc3, myo
  • Feature Type
    protein coding gene
  • IDs
    MGI:97276
    NCBI Gene: 17928
  • Gene Overview
    MyGene.info: MYOG
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:134290004-134292548 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.18 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97276
protein coding gene Chr1:134289989-134292548 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016502
protein coding gene Chr1:137938129-137940688 (+)
A/J MGP_AJ_G0016485
protein coding gene Chr1:132752808-132755367 (+)
AKR/J MGP_AKRJ_G0016450
protein coding gene Chr1:136711998-136714557 (+)
BALB/cJ MGP_BALBcJ_G0016445
protein coding gene Chr1:133086865-133089424 (+)
C3H/HeJ MGP_C3HHeJ_G0016271
protein coding gene Chr1:136812751-136815310 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016906
protein coding gene Chr1:142970311-142972870 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014617
protein coding gene Chr1:125894698-125897316 (+)
CAST/EiJ MGP_CASTEiJ_G0015851
protein coding gene Chr1:135861843-135864402 (+)
CBA/J MGP_CBAJ_G0016244
protein coding gene Chr1:147919411-147921970 (+)
DBA/2J MGP_DBA2J_G0016350
protein coding gene Chr1:131764245-131766804 (+)
FVB/NJ MGP_FVBNJ_G0016349
protein coding gene Chr1:130390821-130393380 (+)
LP/J MGP_LPJ_G0016421
protein coding gene Chr1:139218591-139221150 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016374
protein coding gene Chr1:153622227-153624786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016942
protein coding gene Chr1:136441968-136444527 (+)
PWK/PhJ MGP_PWKPhJ_G0015637
protein coding gene Chr1:130781813-130784452 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015424
protein coding gene Chr1:135407720-135410271 (+)
WSB/EiJ MGP_WSBEiJ_G0015914
protein coding gene Chr1:136473765-136476326 (+)



Homology
more
  • Human Ortholog
    MYOG, myogenin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MYOG, myogenin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHc3, myf-4, MYF4
  • Links
    NCBI Gene ID: 4656
    neXtProt AC: NX_P15173
    UniProt: P15173

  • Chr Location
    1q32.1; chr1:203083129-203086038 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 5 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a severe reduction in muscle mass associated with delayed primary myogenesis and very little secondary myofiber formation, defects of the thoracic skeleton, and perinatal death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17928 NCBI Gene Model | MGI Sequence Detail 2545 C57BL/6J ±  kb
    transcript NM_031189 RefSeq | MGI Sequence Detail 1518 Not Specified  
    polypeptide P12979 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 125
      Genomic 5
      cDNA 70
      Primer pair 22
      Other 28

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12775
    References
    more
    • Summaries
      All 457
      Developmental Gene Expression 328
      Gene Ontology 33
      Phenotypes 33
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:266434 Hong SH, et al., Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory