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Myog Gene Detail
Summary
  • Symbol
    Myog
  • Name
    myogenin
  • Synonyms
    bHLHc3, myo
  • Feature Type
    protein coding gene
  • IDs
    MGI:97276
    NCBI Gene: 17928
  • Gene Overview
    MyGene.info: MYOG
Location & Maps
more
  • Sequence Map
    Chr1:134289989-134292548 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2560 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.18 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    MYOG, myogenin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MYOG, myogenin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHc3, myf-4, MYF4
  • Links
    NCBI Gene ID: 4656
    neXtProt AC: NX_P15173
    UniProt: P15173

  • Chr Location
    1q32.1; chr1:203083129-203086038 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 5 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a severe reduction in muscle mass associated with delayed primary myogenesis and very little secondary myofiber formation, defects of the thoracic skeleton, and perinatal death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049677 VEGA Gene Model | MGI Sequence Detail 2560 C57BL/6J ±  kb
transcript OTTMUST00000126546 VEGA | MGI Sequence Detail 1495 Not Applicable  
polypeptide OTTMUSP00000068414 VEGA | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    45 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 120
    Genomic 5
    cDNA 67
    Primer pair 21
    Other 27

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12775
References
more
  • Summaries
    All 415
    Developmental Gene Expression 314
    Gene Ontology 31
    Phenotypes 33
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:241564 Quinn ME, et al., Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development. Nat Commun. 2017 Jun 01;8:15665

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory