About   Help   FAQ
Myog Gene Detail
Summary
  • Symbol
    Myog
  • Name
    myogenin
  • Synonyms
    bHLHc3, myo
  • Feature Type
    protein coding gene
  • IDs
    MGI:97276
    NCBI Gene: 17928
  • Gene Overview
    MyGene.info: MYOG
Location & Maps
more
  • Sequence Map
    Chr1:134289989-134292548 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2560 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.18 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    MYOG, myogenin (myogenic factor 4)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MYOG, myogenin (myogenic factor 4)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHc3, myf-4, MYF4
  • Links
    NCBI Gene ID: 4656
    neXtProt AC: NX_P15173

  • Chr Location
    1q31-q41; chr1:203083129-203086038 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 5 alleles in 6 genetic backgrounds
    12 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    3 involving Myog
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit a severe reduction in muscle mass associated with delayed primary myogenesis and very little secondary myofiber formation, defects of the thoracic skeleton, and perinatal death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049677 VEGA Gene Model | MGI Sequence Detail 2560 C57BL/6J ±  kb
transcript OTTMUST00000126546 VEGA | MGI Sequence Detail 1495 Not Applicable  
polypeptide OTTMUSP00000068414 VEGA | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    45 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010877 myogenin
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR002546 Myogenic basic muscle-specific protein
Molecular
Reagents
less
  • All nucleic 114
    Genomic 5
    cDNA 66
    Primer pair 18
    Other 25

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12775
References
more
  • Summaries
    All 398
    Developmental Gene Expression 304
    Gene Ontology 30
    Phenotypes 33
  • Earliest
    J:9615 Wright WE, et al., Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD. Cell. 1989 Feb 24;56(4):607-17
  • Latest
    J:230819 Schuster-Gossler K, et al., Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1. Genetics. 2016 Mar;202(3):1119-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory