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Myod1 Gene Detail
Summary
  • Symbol
    Myod1
  • Name
    myogenic differentiation 1
  • Synonyms
    bHLHc1, MYF3, MyoD, Myod-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97275
    NCBI Gene: 17927
  • Gene Overview
    MyGene.info: MYOD1
Location & Maps
more
  • Sequence Map
    Chr7:46376474-46379092 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2619 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 30.03 cM
  • Mapping Data
    37 experiments
Homology
more
  • Human Ortholog
    MYOD1, myogenic differentiation 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYOD1, myogenic differentiation 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHc1, MYF3, MYOD, PUM
  • Links
    NCBI Gene ID: 4654
    neXtProt AC: NX_P15172

  • Chr Location
    11p15.4; chr11:17719563-17722131 (+)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 5 alleles in 4 genetic backgrounds
    29 phenotypes from multigenic genotypes
    2 images
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal muscle development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17927 NCBI Gene Model | MGI Sequence Detail 2619 C57BL/6J ±  kb
transcript NM_010866 RefSeq | MGI Sequence Detail 1854 C57BL/6  
polypeptide P10085 UniProt | EBI | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    66 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010875 myoblast determination protein 1
  • PDB
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR002546 Myogenic basic muscle-specific protein
    IPR022032 Myogenic determination factor 5
Molecular
Reagents
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  • All nucleic 93
    Genomic 8
    cDNA 47
    Primer pair 13
    Other 25

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-12773, MGD-MRK-12774, MGI:2141988
References
more
  • Summaries
    All 511
    Developmental Gene Expression 284
    Diseases 1
    Gene Ontology 59
    Phenotypes 87
  • Earliest
    J:20067 Davis RL, et al., Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell. 1987 Dec 24;51(6):987-1000
  • Latest
    J:232408 Van De Pette M, et al., Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome. PLoS Genet. 2016 Mar;12(3):e1005916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory