Myod1
Gene Detail

Symbol Name ID

Myod1 myogenic differentiation 1 MGI:97275

Synonyms

bHLHc1, MYF3, MyoD, Myod-1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

30.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(37)

Sequence Map

Chr7:46376474-46379092 bp, + strand From NCBI annotation of GRCm38   2619 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7857  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: human myogenin
Gene Tree: Myod1

Human homologs

Human Homolog		MYOD1, myogenic differentiation 1
NCBI Gene ID		4654
neXtProt AC		NX_P15172
Human Synonyms		bHLHc1, MYF3, MYOD, PUM
Human Chr (Location)		11p15.4; chr11:17741110-17743678 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for a knock-out allele exhibit abnormal muscle development.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (55 annotations)

Process	cell differentiation, cellular response to glucocorticoid stimulus, ...
Component	cytoplasm, myofibril, ...
Function	DNA binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (244 records)
Data Summary: Results (684)    Tissues (277)    Images (155)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	39
RNA in situ	462
Northern blot	12
Western blot	4
RT-PCR	153
RNase protection	14

cDNA source data(35)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(82) Genomic(8) cDNA(42) Primer pair(10) Other(22)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000009471 (Evidence)
Entrez Gene	17927 (Evidence)
UniGene	1526
DFCI	TC1583304
DoTS	DT.101714782, DT.94230569
NIA Mouse Gene Index	U008102
PDB	1MDY
Consensus CDS Project	CCDS21277.1
International Mouse Knockout Project Status	Myod1

Sequences

Length	Strain/Species
genomic	17927	NCBI Gene Model | MGI Sequence Detail	2619	C57BL/6J
transcript	NM_010866	RefSeq | MGI Sequence Detail	1854	C57BL/6
polypeptide	P10085	UniProt | EBI | MGI Sequence Detail	318	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(20) : SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
InterPro	IPR002546	Myogenic basic muscle-specific protein
InterPro	IPR022032	Myogenic determination factor 5
Protein Ontology	PR:000010875	myoblast determination protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:20067 Davis RL, et al., Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell. 1987 Dec 24;51(6):987-1000
(Latest) J:194471 Borensztein M, et al., Myod and H19-Igf2 locus interactions are required for diaphragm formation in the mouse. Development. 2013 Mar;140(6):1231-9
All references(438)

Other accession IDs

MGD-MRK-12773, MGD-MRK-12774, MGI:2141988