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Myod1
Gene Detail
Symbol

Name
ID
Myod1
myogenic differentiation 1
MGI:97275
Synonyms
bHLHc1, MYF3, MyoD, Myod-1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
30.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(37)
Sequence Map
Chr7:46376474-46379092 bp, + strand
From NCBI annotation of GRCm38

  2619 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7857  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYOD1
Protein SuperFamily: human myogenin
Gene Tree: Myod1

Human
homologs
MYOD1, myogenic differentiation 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4654
neXtProt AC: NX_P15172

Human Synonyms: bHLHc1, MYF3, MYOD, PUM

Human Chr (Location): 11p15.4; chr11:17719563-17722131 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit abnormal muscle development.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Myod1 interacts with 86 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (96 annotations)
Process cardiac muscle cell differentiation, cell differentiation, ...
Component cytoplasm, myofibril, ...
Function chromatin binding, chromatin DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (274 records)
Data Summary: Results (844)    Tissues (345)    Images (219)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 46
RNA in situ 584
Northern blot 26
Western blot 15
RT-PCR 159
RNase protection 14
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MYOD1 ; Xenbase myod1 ; ZFIN myod1    NEW 
Molecular
reagents
All nucleic(89) Genomic(8) cDNA(45) Primer pair(12) Other(24)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000009471 (Evidence)
Entrez Gene 17927 (Evidence)
UniGene 1526
DFCI TC1583304
DoTS DT.101714782, DT.94230569
NIA Mouse Gene Index U008102
PDB 1MDY
Consensus CDS Project CCDS21277.1
International Mouse Phenotyping Consortium Status Myod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17927 NCBI Gene Model | MGI Sequence Detail 2619 C57BL/6J ±  kb
transcript NM_010866 RefSeq | MGI Sequence Detail 1854 C57BL/6 
polypeptide P10085 UniProt | EBI | MGI Sequence Detail 318 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(20) : SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR002546 Myogenic basic muscle-specific protein
InterPro IPR022032 Myogenic determination factor 5
Protein Ontology PR:000010875 myoblast determination protein 1
Graphical View of Protein Domain Structure
References
(Earliest) J:20067 Davis RL, et al., Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell. 1987 Dec 24;51(6):987-1000
(Latest) J:222174 Cenik BK, et al., Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3. J Clin Invest. 2015 Apr;125(4):1569-78
All references(496)
Other
accession IDs
MGD-MRK-12773, MGD-MRK-12774, MGI:2141988

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory