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Myod1 Gene Detail
Summary
  • Symbol
    Myod1
  • Name
    myogenic differentiation 1
  • Synonyms
    bHLHc1, MYF3, MyoD, Myod-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97275
    NCBI Gene: 17927
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46025898-46028516 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.03 cM
  • Mapping Data
    37 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    20
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97275
 protein coding gene Chr7:46025898-46028523 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032263
 protein coding gene Chr7:46747138-46749741 (+)
A/J MGP_AJ_G0032242
 protein coding gene Chr7:45783108-45785728 (+)
AKR/J MGP_AKRJ_G0032178
 protein coding gene Chr7:47077936-47080539 (+)
BALB/cJ MGP_BALBcJ_G0032254
 protein coding gene Chr7:45788633-45791606 (+)
C3H/HeJ MGP_C3HHeJ_G0031969
 protein coding gene Chr7:47576200-47578803 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032746
 protein coding gene Chr7:49018128-49021926 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029760
 protein coding gene Chr7:48330292-48332913 (+)
CAST/EiJ MGP_CASTEiJ_G0031297
 protein coding gene Chr7:39007107-39009730 (+)
CBA/J MGP_CBAJ_G0031934
 protein coding gene Chr7:50656631-50659234 (+)
DBA/2J MGP_DBA2J_G0032091
 protein coding gene Chr7:45479642-45482245 (+)
FVB/NJ MGP_FVBNJ_G0032043
 protein coding gene Chr7:45264400-45267686 (+)
LP/J MGP_LPJ_G0032170
 protein coding gene Chr7:47442715-47445318 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032080
 protein coding gene Chr7:49291346-49295071 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032761
 protein coding gene Chr7:46288849-46291731 (+)
PWK/PhJ MGP_PWKPhJ_G0031020
 protein coding gene Chr7:38844626-38847907 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030858
 protein coding gene Chr7:34306127-34310135 (+)
WSB/EiJ MGP_WSBEiJ_G0031415
 protein coding gene Chr7:46790612-46793215 (+)



Homology
more
  • Human Ortholog
    MYOD1, myogenic differentiation 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYOD1, myogenic differentiation 1
  • Synonyms
    bHLHc1, CMYP17, MYF3, MYOD, MYODRIF, PUM
  • Links
    NCBI Gene ID: 4654
    neXtProt AC: NX_P15172
    UniProt: P15172

  • Chr Location
    11p15.1; chr11:17719571-17722136 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MYOD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 5 alleles in 4 genetic backgrounds
    32 phenotypes from multigenic genotypes
    2 images
    148 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal muscle development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    68
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2168
  • Tissues
    473
  • cDNA Data
    44
  • Literature Summary
    374
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17927 NCBI Gene Model | MGI Sequence Detail 2619 C57BL/6J ±  kb
    transcript NM_010866 RefSeq | MGI Sequence Detail 1854 ZRU/MplStud  
    polypeptide P10085 UniProt | EBI | MGI Sequence Detail 318 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 132
      Genomic 8
      cDNA 53
      Primer pair 26
      Other 45

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12773, MGD-MRK-12774, MGI:2141988
    References
    more
    • Summaries
      All 726
      Developmental Gene Expression 374
      Diseases 1
      Gene Ontology 68
      Phenotypes 148
    • Earliest
      J:20067 Davis RL, et al., Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell. 1987 Dec 24;51(6):987-1000
    • Latest
      J:346461 Mistretta M, et al., Flvcr1a deficiency promotes heme-based energy metabolism dysfunction in skeletal muscle. Cell Rep. 2024 Feb 26;43(3):113854
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory