About   Help   FAQ
Mylpf Gene Detail
Summary
  • Symbol
    Mylpf
  • Name
    myosin light chain, phosphorylatable, fast skeletal muscle
  • Synonyms
    2410014J02Rik, MLC-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97273
    NCBI Gene: 17907
Location & Maps
more
  • Sequence Map
    Chr7:127208890-127214298 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5409 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.39 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MYLPF, myosin light chain, phosphorylatable, fast skeletal muscle
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MYLPF, myosin light chain, phosphorylatable, fast skeletal muscle
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUMMLC2B, MLC2B, MRLC2, MYL11
  • Links
    NCBI Gene ID: 29895
    neXtProt AC: NX_Q96A32

  • Chr Location
    16p11.2; chr16:30374802-30377989 (+)  GRCh38.p2

Human Diseases
less
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    124
  • Gene trapped
    120
  • Targeted
    4
  • Genomic Mutations
    2 involving Mylpf
Mice homozygous for a disruption in this gene die immediately after birth and completely lack skeletal muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023131 VEGA Gene Model | MGI Sequence Detail 5409 C57BL/6J ±  kb
transcript OTTMUST00000055901 VEGA | MGI Sequence Detail 766 Not Applicable  
polypeptide OTTMUSP00000026815 VEGA | MGI Sequence Detail 169 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    35 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 210
    cDNA 210

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12771, MGI:1915203
References
more
  • Summaries
    All 43
    Developmental Gene Expression 11
    Diseases 5
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:6283 Katcoff D, et al., Construction of recombinant plasmids containing rat muscle actin and myosin light chain DNA sequences. Proc Natl Acad Sci U S A. 1980 Feb;77(2):960-4
  • Latest
    J:222090 Liang QX, et al., Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice. Biol Reprod. 2015 Apr;92(4):97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory