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Mylpf
Gene Detail
Symbol

Name
ID
Mylpf
myosin light chain, phosphorylatable, fast skeletal muscle
MGI:97273
Synonyms
2410014J02Rik, MLC-2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:127211608-127214298 bp, + strand
From VEGA annotation of GRCm38

  2691 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22728  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Mylpf

Human
homologs
Human Homolog MYLPF, myosin light chain, phosphorylatable, fast skeletal muscle
NCBI Gene ID 29895
neXtProt AC  NX_Q96A32
Human Synonyms  HUMMLC2B, MRLC2, MYL11
Human Chr (Location)  16p11.2; chr16:30374802-30377989 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(124) : Gene trapped(120) Targeted(4)
Genomic Mutations involving Mylpf (2)
 
Mice homozygous for a disruption in this gene die immediately after birth and completely lack skeletal muscle.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Mylpf interacts with 11 markers (Mir137, Mir186, Mir187, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process skeletal muscle tissue development
Component lysosomal membrane, myosin complex
Function calcium ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (125)    Tissues (35)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 125
cDNA source data(209)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(210) cDNA(210)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023131 (Evidence)
Ensembl Gene ModelENSMUSG00000030672 (Evidence)
Entrez Gene17907 (Evidence)
UniGene14526
DFCITC1572670, TC1739589
DoTSDT.496570, DT.55141698
NIA Mouse Gene IndexU008793
Consensus CDS ProjectCCDS40140.1
International Mouse Knockout Project StatusMylpf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023131 VEGA Gene Model | MGI Sequence Detail 2691 C57BL/6J ±  kb
transcript OTTMUST00000055901 VEGA | MGI Sequence Detail 766 Not Applicable 
polypeptide OTTMUSP00000026815 VEGA | MGI Sequence Detail 169 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000010847 myosin regulatory light chain 2, skeletal muscle isoform
References
(Earliest) J:6283 Katcoff D, et al., Construction of recombinant plasmids containing rat muscle actin and myosin light chain DNA sequences. Proc Natl Acad Sci U S A. 1980 Feb;77(2):960-4
(Latest) J:213153 Harms MJ, et al., Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014 Apr 1;19(4):593-604
All references(44)
Other
accession IDs
MGD-MRK-12771, MGI:1915203

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory