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Myf6 Gene Detail
Summary
  • Symbol
    Myf6
  • Name
    myogenic factor 6
  • Synonyms
    bHLHc4, herculin, MRF4
  • Feature Type
    protein coding gene
  • IDs
    MGI:97253
    NCBI Gene: 17878
  • Gene Overview
    MyGene.info: MYF6
Location & Maps
more
  • Sequence Map
    Chr10:107492860-107494729 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1870 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 55.96 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    MYF6, myogenic factor 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYF6, myogenic factor 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHc4, CNM3, MRF4, myf-6
  • Links
    NCBI Gene ID: 4618
    neXtProt AC: NX_P23409

  • Chr Location
    12q21; chr12:80707629-80709478 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MYF6 associations

Human Disease Mouse Models
       Myopathy, Centronuclear, 3; CNM3   OMIM: 614408
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    35 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Targeted
    8
  • Genomic Mutations
    1 involving Myf6
  • Incidental Mutations
Homozygotes for targeted mutations exhibit variable rib abnormalities, abnormal intercostal muscle morphology, reduced expression of Myf5, and postnatal mortality proportional to the severity of the rib defect.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035923 Ensembl Gene Model | MGI Sequence Detail 1870 C57BL/6J ±  kb
transcript ENSMUST00000044210 Ensembl | MGI Sequence Detail 1248 Not Applicable  
polypeptide ENSMUSP00000047529 Ensembl | MGI Sequence Detail 242 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    107 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010819 myogenic factor 6
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR002546 Myogenic basic muscle-specific protein
Molecular
Reagents
less
  • All nucleic 37
    Genomic 13
    cDNA 13
    Primer pair 11

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12739
References
more
  • Summaries
    All 124
    Developmental Gene Expression 62
    Diseases 2
    Gene Ontology 11
    Phenotypes 37
  • Earliest
    J:10280 Miner JH, et al., Herculin, a fourth member of the MyoD family of myogenic regulatory genes. Proc Natl Acad Sci U S A. 1990 Feb;87(3):1089-93
  • Latest
    J:231592 Stewart MD, et al., Mouse myofibers lacking the SMYD1 methyltransferase are susceptible to atrophy, internalization of nuclei and myofibrillar disarray. Dis Model Mech. 2016 Mar 1;9(3):347-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory