Myf6
Gene Detail

Symbol Name ID

Myf6 myogenic factor 6 MGI:97253

Synonyms

bHLHc4, herculin, MRF4

Feature Type

protein coding gene

Genetic Map

Chromosome 10

55.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr10:107492860-107494729 bp, - strand From NCBI annotation of GRCm38   1870 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: human myogenin
Gene Tree: Myf6

Human homologs

Human Homolog		MYF6, myogenic factor 6 (herculin)
NCBI Gene ID		4618
neXtProt AC		NX_P23409
Human Synonyms		bHLHc4, CNM3, MRF4, myf-6
Human Chr (Location)		12q21; chr12:81101408-81103257 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MYF6

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for targeted mutations exhibit variable rib abnormalities, abnormal intercostal muscle morphology, reduced expression of Myf5, and postnatal mortality proportional to the severity of the rib defect.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell differentiation, multicellular organismal development, ...
Component	nucleus
Function	DNA binding, protein dimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (57 records)
Data Summary: Results (238)    Tissues (90)    Images (55)
Theiler Stages: 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	154
In situ reporter (knock in)	2
Northern blot	3
RT-PCR	78

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(12) cDNA(11) Primer pair(10)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000035923 (Evidence)
Entrez Gene	17878 (Evidence)
UniGene	11
DFCI	TC1587415
DoTS	DT.60107752
NIA Mouse Gene Index	U032203
Consensus CDS Project	CCDS24162.1
International Mouse Knockout Project Status	Myf6

Sequences

Length	Strain/Species
genomic	17878	NCBI Gene Model | MGI Sequence Detail	1870	C57BL/6J
transcript	NM_008657	RefSeq | MGI Sequence Detail	1248	C57BL/6
polypeptide	P15375	UniProt | EBI | MGI Sequence Detail	242	Not Applicable

All sequences(16) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
InterPro	IPR002546	Myogenic basic muscle-specific protein
Protein Ontology	PR:000010819	myogenic factor 6

Graphical View of Protein Domain Structure

References

(Earliest) J:10280 Miner JH, et al., Herculin, a fourth member of the MyoD family of myogenic regulatory genes. Proc Natl Acad Sci U S A. 1990 Feb;87(3):1089-93
(Latest) J:193353 Borensztein M, et al., Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression. FASEB J. 2012 Nov;26(11):4584-91
All references(114)

Other accession IDs

MGD-MRK-12739