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Myf6
Gene Detail
 Symbol
Name
ID
Myf6
myogenic factor 6
MGI:97253
Synonyms bHLHc4, herculin, MRF4
Feature Type protein coding gene
Genetic Map
Chromosome 10
55.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:107492860-107494729 bp, - strand
From NCBI annotation of GRCm38

  1870 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: human myogenin
Gene Tree: Myf6

Human
homologs
Human Homolog MYF6, myogenic factor 6 (herculin)
NCBI Gene ID 4618
neXtProt AC  NX_P23409
Human Synonyms  bHLHc4, CNM3, MRF4, myf-6
Human Chr (Location)  12q21; chr12:80707629-80709478 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYF6
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Homozygotes for targeted mutations exhibit variable rib abnormalities, abnormal intercostal muscle morphology, reduced expression of Myf5, and postnatal mortality proportional to the severity of the rib defect.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (58 records)
Data Summary: Results (298)    Tissues (142)    Images (60)
Theiler Stages: 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 206
In situ reporter (knock in) 2
Northern blot 3
RT-PCR 86
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(36) Genomic(13) cDNA(12) Primer pair(11)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035923 (Evidence)
Entrez Gene17878 (Evidence)
UniGene11
DFCITC1587415
DoTSDT.60107752
NIA Mouse Gene IndexU032203
Consensus CDS ProjectCCDS24162.1
International Mouse Knockout Project StatusMyf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17878 NCBI Gene Model | MGI Sequence Detail 1870 C57BL/6J ±  kb
transcript NM_008657 RefSeq | MGI Sequence Detail 1248 C57BL/6 
polypeptide P15375 UniProt | EBI | MGI Sequence Detail 242 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR002546 Myogenic basic muscle-specific protein
Protein Ontology PR:000010819 myogenic factor 6
Graphical View of Protein Domain Structure
References (Earliest) J:10280 Miner JH, et al., Herculin, a fourth member of the MyoD family of myogenic regulatory genes. Proc Natl Acad Sci U S A. 1990 Feb;87(3):1089-93
(Latest) J:204551 Park JH, et al., A multifunctional protein, EWS, is essential for early brown fat lineage determination. Dev Cell. 2013 Aug 26;26(4):393-404
All references(118)
Other
accession IDs
MGD-MRK-12739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory