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Myf6
Gene Detail
Symbol

Name
ID
Myf6
myogenic factor 6
MGI:97253
Synonyms
bHLHc4, herculin, MRF4
Feature Type
protein coding gene
Genetic Map
Chromosome 10
55.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:107492860-107494729 bp, - strand
From Ensembl annotation of GRCm38

  1870 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: human myogenin
Gene Tree: Myf6

Human
homologs
Human Homolog MYF6, myogenic factor 6 (herculin)
NCBI Gene ID 4618
neXtProt AC  NX_P23409
Human Synonyms  bHLHc4, CNM3, MRF4, myf-6
Human Chr (Location)  12q21; chr12:80707629-80709478 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYF6
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations exhibit variable rib abnormalities, abnormal intercostal muscle morphology, reduced expression of Myf5, and postnatal mortality proportional to the severity of the rib defect.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Myf6 interacts with 124 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (59 records)
Data Summary: Results (298)    Tissues (144)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 206
In situ reporter (knock in) 2
Northern blot 3
RT-PCR 86
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(13) cDNA(12) Primer pair(11)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035923 (Evidence)
Entrez Gene17878 (Evidence)
UniGene11
DFCITC1587415
DoTSDT.60107752
NIA Mouse Gene IndexU032203
Consensus CDS ProjectCCDS24162.1
International Mouse Knockout Project StatusMyf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035923 Ensembl Gene Model | MGI Sequence Detail 1870 C57BL/6J ±  kb
transcript ENSMUST00000044210 Ensembl | MGI Sequence Detail 1248 Not Applicable 
polypeptide ENSMUSP00000047529 Ensembl | MGI Sequence Detail 242 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR002546 Myogenic basic muscle-specific protein
Protein Ontology PR:000010819 myogenic factor 6
References
(Earliest) J:10280 Miner JH, et al., Herculin, a fourth member of the MyoD family of myogenic regulatory genes. Proc Natl Acad Sci U S A. 1990 Feb;87(3):1089-93
(Latest) J:208787 Kikuchi K, et al., Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma. PLoS Genet. 2014 Jan;10(1):e1004107
All references(121)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory