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Myf5
Gene Detail
Symbol

Name
ID
Myf5
myogenic factor 5
MGI:97252
Synonyms
B130010J22Rik, bHLHc2, Myf-5
Feature Type
protein coding gene
Genetic Map
Chromosome 10
55.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:107482908-107486134 bp, - strand
From Ensembl annotation of GRCm38

  3227 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4085  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYF5
Protein SuperFamily: human myogenin
Gene Tree: Myf5

Human
homologs
MYF5, myogenic factor 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4617
neXtProt AC: NX_P13349

Human Synonyms: bHLHc2

Human Chr (Location): 12q21; chr12:80716929-80719668 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Targeted(18)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit delayed appearance of myotomal cells in somites, and lack the distal portion of ribs resulting in inability to breathe and lethality at birth. Other mutants lack the rib phenotype.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Myf5 interacts with 202 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process camera-type eye development, cartilage condensation, ...
Component nucleoplasm, nucleus
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (221 records)
Data Summary: Results (871)    Tissues (418)    Images (292)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 37
RNA in situ 519
In situ reporter (knock in) 91
Western blot 23
RT-PCR 201
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MYF5 ; Xenbase myf5 ; ZFIN myf5    NEW 
Molecular
reagents
All nucleic(69) Genomic(13) cDNA(23) Primer pair(17) Other(16)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000000435 (Evidence)
Entrez Gene 17877 (Evidence)
UniGene 4984
DFCI TC1589313
DoTS DT.91574458
NIA Mouse Gene Index U032202
Consensus CDS Project CCDS24161.1
International Mouse Phenotyping Consortium Status Myf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000435 Ensembl Gene Model | MGI Sequence Detail 3227 C57BL/6J ±  kb
transcript ENSMUST00000000445 Ensembl | MGI Sequence Detail 2083 Not Applicable 
polypeptide ENSMUSP00000000445 Ensembl | MGI Sequence Detail 255 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR002546 Myogenic basic muscle-specific protein
InterPro IPR022032 Myogenic determination factor 5
Protein Ontology PR:000010818 myogenic factor 5
References
(Earliest) J:30976 Braun T, et al., A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts. EMBO J. 1989 Mar;8(3):701-9
(Latest) J:222055 Lynes MD, et al., Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development. Endocrinology. 2015 May;156(5):1637-47
All references(397)
Other
accession IDs
MGD-MRK-12738, MGI:2445029

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory