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Myf5 Gene Detail
Summary
  • Symbol
    Myf5
  • Name
    myogenic factor 5
  • Synonyms
    B130010J22Rik, bHLHc2, Myf-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:97252
    NCBI Gene: 17877
  • Gene Overview
    MyGene.info: MYF5
Location & Maps
more
  • Sequence Map
    Chr10:107482908-107486134 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3227 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 55.95 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    MYF5, myogenic factor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYF5, myogenic factor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHc2
  • Links
    NCBI Gene ID: 4617
    neXtProt AC: NX_P13349
    UniProt: P13349

  • Chr Location
    12q21.31; chr12:80716929-80719668 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 15 alleles in 9 genetic backgrounds
    91 phenotypes from multigenic genotypes
    176 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit delayed appearance of myotomal cells in somites, and lack the distal portion of ribs resulting in inability to breathe and lethality at birth. Other mutants lack the rib phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000435 Ensembl Gene Model | MGI Sequence Detail 3227 C57BL/6J ±  kb
transcript ENSMUST00000000445 Ensembl | MGI Sequence Detail 2083 Not Applicable  
polypeptide ENSMUSP00000000445 Ensembl | MGI Sequence Detail 255 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    49 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 72
    Genomic 13
    cDNA 25
    Primer pair 17
    Other 17

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12738, MGI:2445029
References
more
  • Summaries
    All 424
    Developmental Gene Expression 232
    Diseases 2
    Gene Ontology 16
    Phenotypes 176
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:238728 Chen Q, et al., A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice. Diabetologia. 2017 Feb;60(2):336-345

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory