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Myf5 Gene Detail
Summary
  • Symbol
    Myf5
  • Name
    myogenic factor 5
  • Synonyms
    B130010J22Rik, bHLHc2, Myf-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:97252
    NCBI Gene: 17877
  • Gene Overview
    MyGene.info: MYF5
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:107482908-107486134 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 55.95 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    49 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97252
protein coding gene Chr10:107482908-107486927 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017708
protein coding gene Chr10:109676370-109679566 (-)
A/J MGP_AJ_G0017685
protein coding gene Chr10:105569055-105572302 (-)
AKR/J MGP_AKRJ_G0017647
protein coding gene Chr10:108635971-108639214 (-)
BALB/cJ MGP_BALBcJ_G0017649
protein coding gene Chr10:105958624-105961840 (-)
C3H/HeJ MGP_C3HHeJ_G0017474
protein coding gene Chr10:108730830-108734076 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018106
protein coding gene Chr10:113477036-113480251 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015785
protein coding gene Chr10:100488115-100491322 (-)
CAST/EiJ MGP_CASTEiJ_G0017035
protein coding gene Chr10:108837453-108841229 (-)
CBA/J MGP_CBAJ_G0017443
protein coding gene Chr10:117893815-117897104 (-)
DBA/2J MGP_DBA2J_G0017548
protein coding gene Chr10:104710689-104713947 (-)
FVB/NJ MGP_FVBNJ_G0017542
protein coding gene Chr10:103706468-103709693 (-)
LP/J MGP_LPJ_G0017622
protein coding gene Chr10:110295792-110299036 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0018144
protein coding gene Chr10:108625749-108628975 (-)
PWK/PhJ MGP_PWKPhJ_G0016817
protein coding gene Chr10:104762788-104766265 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016607
protein coding gene Chr10:107372222-107375442 (-)
WSB/EiJ MGP_WSBEiJ_G0017095
protein coding gene Chr10:108739036-108742266 (-)



Homology
more
  • Human Ortholog
    MYF5, myogenic factor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYF5, myogenic factor 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHc2, EORVA
  • Links
    NCBI Gene ID: 4617
    neXtProt AC: NX_P13349
    UniProt: P13349

  • Chr Location
    12q21.31; chr12:80716929-80719668 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 15 alleles in 9 genetic backgrounds
    108 phenotypes from multigenic genotypes
    206 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit delayed appearance of myotomal cells in somites, and lack the distal portion of ribs resulting in inability to breathe and lethality at birth. Other mutants lack the rib phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000435 Ensembl Gene Model | MGI Sequence Detail 3227 C57BL/6J ±  kb
    transcript ENSMUST00000000445 Ensembl | MGI Sequence Detail 2083 Not Applicable  
    polypeptide ENSMUSP00000000445 Ensembl | MGI Sequence Detail 255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 13
      cDNA 26
      Primer pair 17
      Other 20

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12738, MGI:2445029
    References
    more
    • Summaries
      All 471
      Developmental Gene Expression 241
      Diseases 3
      Gene Ontology 17
      Phenotypes 206
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:263500 Liao J, et al., HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16. Endocrinology. 2018 Jul 1;159(7):2520-2527

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory