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Myf5
Gene Detail
 Symbol
Name
ID
Myf5
myogenic factor 5
MGI:97252
Synonyms B130010J22Rik, bHLHc2, Myf-5
Feature Type protein coding gene
Genetic Map
Chromosome 10
55.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:107482908-107486134 bp, - strand
From NCBI annotation of GRCm38

  3227 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4085  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: human myogenin
Gene Tree: Myf5

Human
homologs
Human Homolog MYF5, myogenic factor 5
NCBI Gene ID 4617
neXtProt AC  NX_P13349
Human Synonyms  bHLHc2
Human Chr (Location)  12q21; chr12:80716929-80719668 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Targeted(18)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit delayed appearance of myotomal cells in somites, and lack the distal portion of ribs resulting in inability to breathe and lethality at birth. Other mutants lack the rib phenotype.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Myf5 interacts with 203 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process camera-type eye development, cartilage condensation, ...
Component nucleus
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (211 records)
Data Summary: Results (861)    Tissues (414)    Images (287)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 37
RNA in situ 514
In situ reporter (knock in) 86
Western blot 23
RT-PCR 201
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(68) Genomic(13) cDNA(22) Primer pair(17) Other(16)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000000435 (Evidence)
Entrez Gene17877 (Evidence)
UniGene4984
DFCITC1589313
DoTSDT.91574458
NIA Mouse Gene IndexU032202
Consensus CDS ProjectCCDS24161.1
International Mouse Knockout Project StatusMyf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17877 NCBI Gene Model | MGI Sequence Detail 3227 C57BL/6J ±  kb
transcript NM_008656 RefSeq | MGI Sequence Detail 2083 C57BL/6 
polypeptide P24699 UniProt | EBI | MGI Sequence Detail 255 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR002546 Myogenic basic muscle-specific protein
InterPro IPR022032 Myogenic determination factor 5
Protein Ontology PR:000010818 myogenic factor 5
Graphical View of Protein Domain Structure
References (Earliest) J:30976 Braun T, et al., A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts. EMBO J. 1989 Mar;8(3):701-9
(Latest) J:212185 Petchey LK, et al., Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9515-20
All references(378)
Other
accession IDs
MGD-MRK-12738, MGI:2445029

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory