Myf5
Gene Detail

Symbol Name ID

Myf5 myogenic factor 5 MGI:97252

Synonyms

B130010J22Rik, bHLHc2, Myf-5

Feature Type

protein coding gene

Genetic Map

Chromosome 10

55.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr10:107482908-107486134 bp, - strand From NCBI annotation of GRCm38   3227 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4085  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: human myogenin
Gene Tree: Myf5

Human homologs

Human Homolog		MYF5, myogenic factor 5
NCBI Gene ID		4617
neXtProt AC		NX_P13349
Human Synonyms		bHLHc2
Human Chr (Location)		12q21; chr12:81110708-81113447 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(15)
 

Homozygotes for targeted null mutations exhibit delayed appearance of myotomal cells in somites, and lack the distal portion of ribs resulting in inability to breathe and lethality at birth. Other mutants lack the rib phenotype.

 
Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	camera-type eye development, cartilage condensation, ...
Component	nucleus
Function	DNA binding, protein dimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (200 records)
Data Summary: Results (763)    Tissues (346)    Images (247)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	26
RNA in situ	430
In situ reporter (knock in)	84
Western blot	23
RT-PCR	200

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(61) Genomic(13) cDNA(20) Primer pair(15) Other(13)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000000435 (Evidence)
Entrez Gene	17877 (Evidence)
UniGene	4984
DFCI	TC1589313
DoTS	DT.91574458
NIA Mouse Gene Index	U032202
Consensus CDS Project	CCDS24161.1
International Mouse Knockout Project Status	Myf5

Sequences

Length	Strain/Species
genomic	17877	NCBI Gene Model | MGI Sequence Detail	3227	C57BL/6J
transcript	NM_008656	RefSeq | MGI Sequence Detail	2083	C57BL/6
polypeptide	P24699	UniProt | EBI | MGI Sequence Detail	255	Not Applicable

All sequences(18) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(34 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
InterPro	IPR002546	Myogenic basic muscle-specific protein
InterPro	IPR022032	Myogenic determination factor 5
Protein Ontology	PR:000010818	myogenic factor 5

Graphical View of Protein Domain Structure

References

(Earliest) J:30976 Braun T, et al., A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts. EMBO J. 1989 Mar;8(3):701-9
(Latest) J:192190 Picard CA, et al., Two distinct muscle progenitor populations coexist throughout amniote development. Dev Biol. 2013 Jan 1;373(1):141-8
All references(348)

Other accession IDs

MGD-MRK-12738, MGI:2445029