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Mxi1
Gene Detail
 Symbol
Name
ID
Mxi1
Max interacting protein 1
MGI:97245
Synonyms bHLHc11, Mad2
Feature Type protein coding gene
Genetic Map
Chromosome 19
47.53 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr19:53310506-53375810 bp, + strand
From NCBI annotation of GRCm38

  65305 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4351  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: MAX interacting protein
Gene Tree: Mxi1

Human
homologs
Human Homolog MXI1, MAX interactor 1, dimerization protein
NCBI Gene ID 4601
neXtProt AC  NX_P50539
Human Synonyms  bHLHc11, MAD2, MXD2, MXI
Human Chr (Location)  10q24-q25; chr10:110207605-110287365 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MXI1
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(29) Targeted(2)
Incidental mutations (data from APF )
 
Homozygous null mice show multisystem anomalies including progressive hyperplasia in the spleen and prostate, degenerative changes in the kidney, and increased sensitivity to carcinogens. In addition, mutant embryo fibroblasts are more prone to transformation by the Myc and Ras oncogenes.
 
Interactions
Mxi1 interacts with 415 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-templated, ...
Component cytoplasm, nucleolus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (296)    Tissues (252)    Images (23)
Theiler Stages: 13, 15, 16, 17, 19, 20, 21, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 266
RT-PCR 16
RNase protection 14
cDNA source data(100)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(107) Genomic(1) cDNA(102) Primer pair(4)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000025025 (Evidence)
Entrez Gene17859 (Evidence)
UniGene2154
DoTSDT.101384159, DT.101384161, DT.101384163, DT.533318, DT.55223517, DT.91344828, DT.94369168
Consensus CDS ProjectCCDS29901.1, CCDS38022.1, CCDS38023.1
International Mouse Knockout Project StatusMxi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17859 NCBI Gene Model | MGI Sequence Detail 65305 C57BL/6J ±  kb
transcript NM_001008542 RefSeq | MGI Sequence Detail 5156 C57BL/6 
polypeptide P50540 UniProt | EBI | MGI Sequence Detail 228 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(22) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010793 max-interacting protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:16599 Edelhoff S, et al., Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. Oncogene. 1994 Feb;9(2):665-8
(Latest) J:196712 Ko JY, et al., Inactivation of max-interacting protein 1 induces renal cilia disassembly through reduction in levels of intraflagellar transport 20 in polycystic kidney. J Biol Chem. 2013 Mar 1;288(9):6488-97
All references(61)
Other
accession IDs
MGD-MRK-12730

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory