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Mxi1 Gene Detail
Summary
  • Symbol
    Mxi1
  • Name
    MAX interactor 1, dimerization protein
  • Synonyms
    bHLHc11, Mad2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97245
    NCBI Gene: 17859
  • Gene Overview
    MyGene.info: MXI1
Location & Maps
more
  • Sequence Map
    Chr19:53310506-53375810 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65305 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 47.53 cM, cytoband D
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    MXI1, MAX interactor 1, dimerization protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MXI1, MAX interactor 1, dimerization protein
    Orthology source: HomoloGene
  • Synonyms
    bHLHc11, MAD2, MXD2, MXI
  • Links
    NCBI Gene ID: 4601
    neXtProt AC: NX_P50539

  • Chr Location
    10q24-q25; chr10:110207605-110287365 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MXI1 associations

Human Disease Mouse Models
       Prostate Cancer   OMIM: 176807
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Gene trapped
    29
  • Targeted
    2
  • Incidental Mutations
    APF
Homozygous null mice show multisystem anomalies including progressive hyperplasia in the spleen and prostate, degenerative changes in the kidney, and increased sensitivity to carcinogens. In addition, mutant embryo fibroblasts are more prone to transformation by the Myc and Ras oncogenes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025025 Ensembl Gene Model | MGI Sequence Detail 65305 C57BL/6J ±  kb
transcript ENSMUST00000003870 Ensembl | MGI Sequence Detail 5156 Not Applicable  
polypeptide ENSMUSP00000003870 Ensembl | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    243 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010793 max-interacting protein 1
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 107
    Genomic 1
    cDNA 102
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12730
References
more
  • Summaries
    All 58
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:16599 Edelhoff S, et al., Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. Oncogene. 1994 Feb;9(2):665-8
  • Latest
    J:196712 Ko JY, et al., Inactivation of max-interacting protein 1 induces renal cilia disassembly through reduction in levels of intraflagellar transport 20 in polycystic kidney. J Biol Chem. 2013 Mar 1;288(9):6488-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory