Mxi1
Gene Detail

Symbol Name ID

Mxi1 Max interacting protein 1 MGI:97245

Synonyms

bHLHc11, Mad2

Feature Type

protein coding gene

Genetic Map

Chromosome 19

47.53 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr19:53310506-53375810 bp, + strand From NCBI annotation of GRCm38   65305 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4351  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: MAX interacting protein
Gene Tree: Mxi1

Human homologs

Human Homolog		MXI1, MAX interactor 1, dimerization protein
NCBI Gene ID		4601
neXtProt AC		NX_P50539
Human Synonyms		bHLHc11, MAD2, MXD2, MXI
Human Chr (Location)		10q24-q25; chr10:111967363-112047123 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MXI1

Alleles and phenotypes

All alleles(31) : Targeted(2) Gene trapped(29)
 

Homozygous null mice show multisystem anomalies including progressive hyperplasia in the spleen and prostate, degenerative changes in the kidney, and increased sensitivity to carcinogens. In addition, mutant embryo fibroblasts are more prone to transformation by the Myc and Ras oncogenes.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, ...
Component	nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (247)    Tissues (196)    Images (21)
Theiler Stages: 13, 15, 16, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	217
RT-PCR	16
RNase protection	14

cDNA source data(96)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(103) Genomic(1) cDNA(98) Primer pair(4)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000025025 (Evidence)
Entrez Gene	17859 (Evidence)
UniGene	2154
DoTS	DT.101384159, DT.101384161, DT.101384163, DT.533318, DT.55223517, DT.91344828, DT.94369168
Consensus CDS Project	CCDS29901.1, CCDS38022.1, CCDS38023.1
International Mouse Knockout Project Status	Mxi1

Sequences

Length	Strain/Species
genomic	17859	NCBI Gene Model | MGI Sequence Detail	65305	C57BL/6J
transcript	NM_001008542	RefSeq | MGI Sequence Detail	5156	C57BL/6
polypeptide	P50540	UniProt | EBI | MGI Sequence Detail	228	Not Applicable

All sequences(42) RefSeq(6) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(225 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology	PR:000010793	max-interacting protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:16599 Edelhoff S, et al., Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. Oncogene. 1994 Feb;9(2):665-8
(Latest) J:184831 Uchibe K, et al., Identification of novel transcription-regulating genes expressed during murine molar development. Dev Dyn. 2012 Jul;241(7):1217-26
All references(58)

Other accession IDs

MGD-MRK-12730