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Mx2 Pseudogene Detail
Summary
  • Symbol
    Mx2
  • Name
    MX dynamin-like GTPase 2
  • Synonyms
    Mx-2
  • Feature Type
    polymorphic pseudogene
  • IDs
    MGI:97244
    NCBI Gene: 17858
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:97536081-97560901 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 57.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97244
polymorphic pseudogene Chr16:97535308-97560901 (.)
129S1/SvImJ MGP_129S1SvImJ_G0009937
polymorphic pseudogene Chr16:98975321-99001926 (+)
A/J MGP_AJ_G0009921
polymorphic pseudogene Chr16:94306282-94333178 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0009906
polymorphic pseudogene Chr16:94852897-94879920 (+)
C3H/HeJ MGP_C3HHeJ_G0009838
polymorphic pseudogene Chr16:97732722-97759089 (+)
C57BL/6NJ MGP_C57BL6NJ_G0010152
polymorphic pseudogene Chr16:102065499-102096467 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0008949
polymorphic pseudogene Chr16:92139309-92168414 (+)
CAST/EiJ MGP_CASTEiJ_G0009656
polymorphic pseudogene Chr16:98540562-98573150 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0009839
polymorphic pseudogene Chr16:94165560-94193426 (+)
FVB/NJ MGP_FVBNJ_G0009856
polymorphic pseudogene Chr16:93326378-93353473 (+)
LP/J MGP_LPJ_G0009934
polymorphic pseudogene Chr16:98621960-98651094 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0009823
polymorphic pseudogene Chr16:110647208-110674730 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0010125
polymorphic pseudogene Chr16:97756736-97786036 (+)
PWK/PhJ MGP_PWKPhJ_G0009577
polymorphic pseudogene Chr16:94506985-94522251 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0009758
polymorphic pseudogene Chr16:98025523-98054325 (+)



Homology
more
  • Human Ortholog
    MX1, MX dynamin like GTPase 1
  • Human Ortholog
    MX1, MX dynamin like GTPase 1
    Orthology source: HGNC
  • Synonyms
    IFI78, IFI-78K, MX, MxA
  • Links
    NCBI Gene ID: 4599
    neXtProt AC: NX_P20591
    UniProt: P20591

  • Chr Location
    21q22.3; chr21:41420329-41459214 (+)  GRCh38.p7

  • Human Ortholog
    MX2, MX dynamin like GTPase 2
    Orthology source: HGNC
  • Synonyms
    MXB
  • Links
    NCBI Gene ID: 4600
    neXtProt AC: NX_P20592
    UniProt: P20592

  • Chr Location
    21q22.3; chr21:41361986-41408943 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
Mx1+ strains do not express MX2 protein. The Mx2 gene in BALB/cJ and CBA/J is interrupted by an open reading frame mutation. Mutagenesis correcting the frameshift permits Mx2 expression in 3T3 cells. This protein did not inhibit influenza virus but conferred resistance to vesicular stomatitis virus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic 17858 NCBI Gene Model | MGI Sequence Detail 24821 C57BL/6J ±  kb
transcript NR_003508 RefSeq | MGI Sequence Detail 2428 C57BL/6  
polypeptide Q9WVP9 UniProt | EBI | MGI Sequence Detail 655 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR000375 Dynamin central domain
    IPR001401 Dynamin, GTPase domain
    IPR003130 Dynamin GTPase effector
    IPR019762 Dynamin, GTPase region, conserved site
    IPR022812 Dynamin superfamily
    IPR030381 Dynamin-type guanine nucleotide-binding (G) domain
    IPR020850 GTPase effector domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 32
    cDNA 29
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12727, MGD-MRK-12729, MGI:2146454
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:13136 LINDENMANN J, INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE. Proc Soc Exp Biol Med. 1964 Jun;116:506-9
  • Latest
    J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory