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Mx2
Gene Detail
 Symbol
Name
ID
Mx2
myxovirus (influenza virus) resistance 2
MGI:97244
Strain-Specific Marker
Synonyms Mx-2
Feature Type protein coding gene
Genetic Map
Chromosome 16
57.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:97536083-97560899 bp, + strand
From Ensembl annotation of GRCm38

  24817 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: dynamin-related, VPS1
Gene Tree: Mx2
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
 
Mx1+ strains do not express MX2 protein. The Mx2 gene in BALB/cJ and CBA/J is interrupted by an open reading frame mutation. Mutagenesis correcting the frameshift permits Mx2 expression in 3T3 cells. This protein did not inhibit influenza virus but conferred resistance to vesicular stomatitis virus.
 
Interactions
Mx2 interacts with 63 markers (Mir1a-1, Mir1a-2, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process defense response to virus, GTP catabolic process, ...
Component cytoplasm
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (207)    Tissues (64)    Images (4)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26, 28
Assay TypeResults
RNA in situ 189
RT-PCR 18
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(28) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000023341 (Evidence)
Entrez Gene17858 (Evidence)
UniGene14157
DoTSDT.101268561, DT.40152162
NIA Mouse Gene IndexU017430
International Mouse Knockout Project StatusMx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023341 Ensembl Gene Model | MGI Sequence Detail 24817 C57BL/6J ±  kb
transcript ENSMUST00000024112 Ensembl | MGI Sequence Detail 2417 Not Applicable 
polypeptide ENSMUSP00000024112 Ensembl | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(3) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(34 from dbSNP Build 137)    SNPs within 2kb including multiple locations(38)
Protein-related
information
ResourceIDDescription
InterPro IPR022812 Dynamin
InterPro IPR000375 Dynamin central domain
InterPro IPR001401 Dynamin, GTPase domain
InterPro IPR003130 Dynamin GTPase effector
InterPro IPR019762 Dynamin, GTPase region, conserved site
InterPro IPR020850 GTPase effector domain, GED
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010789 interferon-induced GTP-binding protein Mx2
References (Earliest) J:13136 LINDENMANN J, INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE. Proc Soc Exp Biol Med. 1964 Jun;116:506-9
(Latest) J:188254 Budry L, et al., The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev. 2012 Oct 15;26(20):2299-310
All references(37)
Other
accession IDs
MGD-MRK-12727, MGD-MRK-12729, MGI:2146454

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory