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Mx2 Gene Detail
Summary
  • Symbol
    Mx2
  • Name
    MX dynamin-like GTPase 2
  • Synonyms
    Mx-2
Location & Maps
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  • Sequence Map
    Chr16:97535308-97560900 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25593 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 57.51 cM
  • Mapping Data
    2 experiments
Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Genomic Mutations
    4 involving Mx2
  • Incidental Mutations
Mx1+ strains do not express MX2 protein. The Mx2 gene in BALB/cJ and CBA/J is interrupted by an open reading frame mutation. Mutagenesis correcting the frameshift permits Mx2 expression in 3T3 cells. This protein did not inhibit influenza virus but conferred resistance to vesicular stomatitis virus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047542 VEGA Gene Model | MGI Sequence Detail 25593 C57BL/6J ±  kb
transcript OTTMUST00000122647 VEGA | MGI Sequence Detail 2421 Not Applicable  
polypeptide OTTMUSP00000067211 VEGA | MGI Sequence Detail 656 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    34 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR000375 Dynamin central domain
    IPR001401 Dynamin, GTPase domain
    IPR003130 Dynamin GTPase effector
    IPR019762 Dynamin, GTPase region, conserved site
    IPR022812 Dynamin superfamily
    IPR030381 Dynamin-type guanine nucleotide-binding (G) domain
    IPR020850 GTPase effector domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 30
    cDNA 28
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12727, MGD-MRK-12729, MGI:2146454
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:13136 LINDENMANN J, INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE. Proc Soc Exp Biol Med. 1964 Jun;116:506-9
  • Latest
    J:188254 Budry L, et al., The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev. 2012 Oct 15;26(20):2299-310

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory