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Mx1 Gene Detail
Summary
  • Symbol
    Mx1
  • Name
    MX dynamin-like GTPase 1
  • Synonyms
    Mx, Mx-1, myxovirus (influenza) resistance 1 polypeptide
Location & Maps
more
  • Sequence Map
    Chr16:97447035-97462907 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15873 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 57.46 cM, cytoband C4
  • Mapping Data
    40 experiments
Homology
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  • Human Ortholog
    MX1, MX dynamin like GTPase 1
  • Human Ortholog
    MX1, MX dynamin like GTPase 1
    Orthology source: HGNC
  • Synonyms
    IFI78, IFI-78K, MX, MxA
  • Links
    NCBI Gene ID: 4599
    neXtProt AC: NX_P20591

  • Chr Location
    21q22.3; chr21:41420329-41459214 (+)  GRCh38.p2

  • Human Ortholog
    MX2, MX dynamin like GTPase 2
    Orthology source: HGNC
  • Synonyms
    MXB
  • Links
    NCBI Gene ID: 4600
    neXtProt AC: NX_P20592

  • Chr Location
    21q22.3; chr21:41361986-41408943 (+)  GRCh38.p2

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 4 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    1
  • Spontaneous
    3
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    4 involving Mx1
  • Incidental Mutations
A2G, SL/NiA, T9 and CAST/Ei strains produce the MX1 protein (Mx1+ allele) conferring resistance to myxoviruses, whereas no protein is made by the Mx1- susceptible alleles of C57BL/6J and many other inbred strains with an exon 9-11 deletion; or CBA/J, CE/J, I/LnJ and PERA/Ei with a nonsense mutation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016636 VEGA Gene Model | MGI Sequence Detail 15873 C57BL/6J ±  kb
transcript OTTMUST00000040247 VEGA | MGI Sequence Detail 2695 Not Applicable  
polypeptide OTTMUSP00000017972 VEGA | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    53 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • InterPro Domains
    IPR000375 Dynamin central domain
    IPR001401 Dynamin, GTPase domain
    IPR003130 Dynamin GTPase effector
    IPR019762 Dynamin, GTPase region, conserved site
    IPR022812 Dynamin superfamily
    IPR030381 Dynamin-type guanine nucleotide-binding (G) domain
    IPR020850 GTPase effector domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 44
    Genomic 10
    cDNA 28
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12725, MGD-MRK-12726, MGD-MRK-12728, MGI:2146518
References
more
  • Summaries
    All 104
    Developmental Gene Expression 2
    Diseases 3
    Gene Ontology 6
    Phenotypes 47
  • Earliest
    J:13136 LINDENMANN J, INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE. Proc Soc Exp Biol Med. 1964 Jun;116:506-9
  • Latest
    J:234468 Yockey LJ, et al., Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. Cell. 2016 Aug 25;166(5):1247-1256.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory