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Mx1
Gene Detail
 Symbol
Name
ID
Mx1
myxovirus (influenza virus) resistance 1
MGI:97243
Strain-Specific Marker
Synonyms Mx, Mx-1, myxovirus (influenza) resistance 1 polypeptide
Feature Type protein coding gene
Genetic Map
Chromosome 16
57.46 cM, cytoband C4
Detailed Genetic Map ± 1 cM


Mapping data(39)
Sequence Map
Chr16:97447035-97462907 bp, - strand
From VEGA annotation of GRCm38

  15873 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: dynamin-related, VPS1
Gene Tree: Mx1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Spontaneous(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
A2G, SL/NiA, T9 and CAST/Ei strains produce the MX1 protein (Mx1+ allele) conferring resistance to myxoviruses, whereas no protein is made by the Mx1- susceptible alleles of C57BL/6J and many other inbred strains with an exon 9-11 deletion; or CBA/J, CE/J, I/LnJ and PERA/Ei with a nonsense mutation.
 
Interactions
Mx1 interacts with 172 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process defense response to virus, GTP catabolic process, ...
Component nucleus
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (19)    Tissues (17)   
Theiler Stages: 13, 15, 20, 23, 26, 28
Assay TypeResults
RNA in situ 1
RT-PCR 18
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(10) cDNA(28) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016636 (Evidence)
Ensembl Gene ModelENSMUSG00000000386 (Evidence)
Entrez Gene17857 (Evidence)
UniGene33996
DoTSDT.101344076, DT.101359347, DT.101721060, DT.110715125, DT.533397
NIA Mouse Gene IndexU037347
International Mouse Knockout Project StatusMx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016636 VEGA Gene Model | MGI Sequence Detail 15873 C57BL/6J ±  kb
transcript OTTMUST00000040247 VEGA | MGI Sequence Detail 2695 Not Applicable 
polypeptide OTTMUSP00000017972 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(3) UniProt(12)
Polymorphisms All PCR and RFLP(20) : PCR(2) RFLP(18) SNPs within 2kb(55 from dbSNP Build 137)    SNPs within 2kb including multiple locations(59)
Protein-related
information
ResourceIDDescription
InterPro IPR022812 Dynamin
InterPro IPR000375 Dynamin central domain
InterPro IPR001401 Dynamin, GTPase domain
InterPro IPR003130 Dynamin GTPase effector
InterPro IPR019762 Dynamin, GTPase region, conserved site
InterPro IPR020850 GTPase effector domain, GED
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010788 interferon-induced GTP-binding protein Mx1
References (Earliest) J:13136 LINDENMANN J, INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE. Proc Soc Exp Biol Med. 1964 Jun;116:506-9
(Latest) J:205265 Frese M, et al., Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of Beta interferon coexpression on vaccine properties. J Virol. 2014 Feb;88(4):2056-70
All references(100)
Other
accession IDs
MGD-MRK-12725, MGD-MRK-12726, MGD-MRK-12728, MGI:2146518

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory