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Map4 Gene Detail
Summary
  • Symbol
    Map4
  • Name
    microtubule-associated protein 4
  • Synonyms
    MAP 4, Mtap4
  • Feature Type
    protein coding gene
  • IDs
    MGI:97178
    NCBI Gene: 17758
  • Alliance
    genome feature page
  • Transcription Start Sites
    63 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:109760528-109913023 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.83 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3500 from dbSNP Build 142
  • Strain Annotations
    26
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97178
 protein coding gene Chr9:109758909-109913023 (+)
129S1/SvImJ ENSMUSGG00200054511
 protein coding gene Chr9:106900553-106927427 (+)
129S1/SvImJ ENSMUSG00200040249
 protein coding gene Chr9:106973743-107005639 (+)
A/J ENSMUSG00195041954
 protein coding gene Chr9:106267183-106299082 (+)
A/J ENSMUSGG00195055478
 protein coding gene Chr9:106193998-106220873 (+)
AKR/J ENSMUSG00220022086
 protein coding gene Chr9:106602909-106634806 (+)
AKR/J ENSMUSGG00220054417
 protein coding gene Chr9:106529721-106556595 (+)
BALB/cJ ENSMUSG00180028601
 protein coding gene Chr9:106722104-106754003 (+)
BALB/cJ ENSMUSGG00180055143
 protein coding gene Chr9:106648913-106675789 (+)
C3H/HeJ ENSMUSGG00175054706
 protein coding gene Chr9:106864791-106891667 (+)
C3H/HeJ ENSMUSG00175034710
 protein coding gene Chr9:106937972-106969863 (+)
C57BL/6NJ ENSMUSGG00215055260
 protein coding gene Chr9:106744697-106771587 (+)
C57BL/6NJ ENSMUSG00215015492
 protein coding gene Chr9:106817893-106849792 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032724
 protein coding gene Chr9:105211468-105363284 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054656
 protein coding gene Chr9:106585402-106612070 (+)
CBA/J ENSMUSG00210031038
 protein coding gene Chr9:106660997-106692676 (+)
DBA/2J ENSMUSGG00185057904
 protein coding gene Chr9:106912788-106939662 (+)
DBA/2J ENSMUSG00185042995
 protein coding gene Chr9:106985967-107017874 (+)
FVB/NJ ENSMUSGG00205054603
 protein coding gene Chr9:106842454-106869755 (+)
FVB/NJ ENSMUSG00205046249
 protein coding gene Chr9:106922549-106954492 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230047552
 protein coding gene Chr9:107105941-107137841 (+)
LP/J ENSMUSGG00230055374
 protein coding gene Chr9:107032757-107059632 (+)
NOD/ShiLtJ ENSMUSGG00190054594
 protein coding gene Chr9:106500405-106527279 (+)
NOD/ShiLtJ ENSMUSG00190045456
 protein coding gene Chr9:106573576-106605474 (+)
NZO/HlLtJ ENSMUSGG00225055213
 protein coding gene Chr9:107282587-107309457 (+)
NZO/HlLtJ ENSMUSG00225023983
 protein coding gene Chr9:107355769-107387667 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MAP4, microtubule associated protein 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP4, microtubule associated protein 4
  • Links
    NCBI Gene ID: 4134
    UniProt: P27816

  • Chr Location
    3p21.31; chr3:47850678-48089295 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele are viable and do not display any overt phenotypic abnormalities. Male mice homozygous for a null allele display reduced grip strength.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    642
  • Tissues
    26
  • cDNA Data
    30
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032479 Ensembl Gene Model | MGI Sequence Detail 152496 C57BL/6J ±  kb
    transcript ENSMUST00000163190 Ensembl | MGI Sequence Detail 4322 Not Applicable  
    polypeptide ENSMUSP00000143171 Ensembl | MGI Sequence Detail 1441 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • Protein Ontology
      PR:000010142 microtubule-associated protein 4
      (term hierarchy)
    • InterPro Domains
      IPR027324 Microtubule associated protein MAP2/MAP4/Tau
      IPR001084 Microtubule associated protein, tubulin-binding repeat
    • GlyGen
      P27546 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 35
      Primer pair 1
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12582, MGD-MRK-12588, MGI:2142906
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:11537 West RR, et al., A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences. J Biol Chem. 1991 Nov 15;266(32):21886-96
    • Latest
      J:358165 Lucas L, et al., Alternatively spliced MAP4 isoforms have key roles in maintaining microtubule organization and skeletal muscle function. iScience. 2024 Nov 15;27(11):111104
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory